DSCR9 and LMO7

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		DSCR9	LMO7
Description		Down syndrome critical region 9	LIM domain 7
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component	Ubiquitin Ligase Complex Nucleus Nuclear Envelope Cytoplasm Mitochondrion Cytosol Focal Adhesion Cell Surface Apical Plasma Membrane
	Molecular Function	Molecular_function	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding
	Biological Process	Biological_process	Positive Regulation Of Macromolecule Metabolic Process Protein Ubiquitination Regulation Of Signaling Regulation Of Cell Adhesion Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process
Pathways			Neddylation Signaling by ALK fusions and activated point mutants Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Eye color traits ( 20463881) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189)	Age-related hearing impairment ( 34108613) Cutaneous melanoma or hair colour ( 32341527) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 29449654 33627673) Initial pursuit acceleration ( 29064472) Initial pursuit acceleration in psychotic disorders ( 29064472) Intraocular pressure ( 29617998 29785010 30054594 31959993) Mean corpuscular hemoglobin ( 32888494) Multiple system atrophy (pathologically confirmed) ( 27629089) Obsessive-compulsive disorder ( 30456828) Type 1 diabetes ( 21980299)
Interacting Genes		146 interacting genes: ACTB ACTN4 ACTR3B ADAMTS8 ADGRB3 AKAP8L ALDOA APP ASB3 ASH1L ATXN10 BEX3 BFSP1 BICD2 BTBD1 CCDC6 CD74 CELSR3 CERCAM CIAO3 CLTC CLU CNKSR1 CNOT2 COPB1 COPS4 CREBZF CTSB CXXC5 DARS1 DCAF6 DDX3X DIS3L DNAJA1 DPYSL2 DST DYNC1H1 EFEMP1 EXTL3 EYA3 FAN1 FBH1 FBXL16 FBXO11 FN1 FN3K FUZ GAR1 GIT1 GNPTAB GPRASP2 GUCY1B1 HDAC6 HNRNPK HPF1 HPS4 IFT122 IMMT ITCH JAKMIP1 KALRN KDM5A KIF1A KIF3A KLHL7 LMO7 LONRF1 LRP4 MACF1 MCRS1 METTL8 MIPOL1 MORF4L1 MTMR3 MTUS2 MYCBP2 NAGK NARS1 NBEA NCBP1 NDUFA10 NDUFB7 NEUROD6 NFE2L3 NIPBL NR4A2 OLR1 P4HTM PAK1 PAK2 PBXIP1 PCCB PDCD7 PDE4DIP PICK1 PIK3R4 PLEKHB1 PLXNB3 PPP4R1 PRKAR1A PSMC1 PSMD2 QRICH1 RAP1GAP RNF10 RSBN1L SBNO1 SEC23IP SESN3 SGSM2 SMPD3 SMURF2 SNX5 SPARCL1 SPOCK2 SPRED1 SPRY2 SPTBN1 STAMBP STX1A SULF1 SYNE1 TARS1 TNKS2 TPP1 TRIM5 TRIO TRIOBP TRIP12 TSG101 TTYH1 USP33 USP47 USP8 VARS1 VPS54 VPS9D1 WDR13 WDR26 WDR47 WRAP53 XAB2 XRN2 ZNF528 ZNFX1 ZRSR2	15 interacting genes: ABCA1 ANXA1 CALM1 DAPK3 DSCR9 EMD LRIG3 MDM2 PKM RHOU SRPK2 SUMO2 TBK1 UBAC2 YWHAG
Entrez ID		257203	4008
HPRD ID		10925	05078
Ensembl ID		ENSG00000230366	ENSG00000136153
Uniprot IDs			A0A0A0MTE2 E9PMT2 F8J2B5 F8WD26 Q8WWI1
PDB IDs			2EAQ
Enriched GO Terms of Interacting Partners?		Cytoplasm Cytoskeleton Macromolecule Metabolic Process Cytosol Protein Metabolic Process Post-translational Protein Modification Protein Modification Process Intracellular Protein Localization Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Amyloid Fibril Formation Small GTPase Binding Cytoskeleton-dependent Intracellular Transport Identical Protein Binding Regulation Of Signal Transduction Vesicle-mediated Transport Neuron Projection Morphogenesis Transport Along Microtubule Regulation Of Wnt Signaling Pathway Protein Modification By Small Protein Conjugation Cell Projection Morphogenesis Positive Regulation Of Cellular Component Organization Positive Regulation Of Microtubule Nucleation Regulation Of Cellular Component Organization Microtubule Negative Regulation Of Signal Transduction Organelle Organization Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Organelle Organization Catabolic Process Low-density Lipoprotein Particle Receptor Binding Axo-dendritic Transport Macromolecule Catabolic Process Protein Ubiquitination Regulation Of Microtubule Cytoskeleton Organization Regulation Of Signaling Microtubule-based Transport Regulation Of Supramolecular Fiber Organization Regulation Of Intracellular Signal Transduction Centrosome Nucleus Intracellular Transport Cellular Localization Axon Cytoplasm Regulation Of Cellular Response To Stress Regulation Of Cell Communication Establishment Of Protein Localization To Vacuole Platelet Alpha Granule Lumen Establishment Of Localization In Cell Regulation Of Intrinsic Apoptotic Signaling Pathway	Vesicle Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Protein Export From Nucleus SUMO Transferase Activity Regulation Of Signal Transduction Protein Metabolic Process Protein Modification Process Cellular Response To Hormone Stimulus Regulation Of Cell Shape Presynaptic Cytosol Regulation Of Intracellular Protein Transport Amyloid Fibril Formation Positive Regulation Of Translation Positive Regulation Of Gene Expression Intracellular Signal Transduction Regulation Of Translation Regulation Of Protein Export From Nucleus Positive Regulation Of Protein Metabolic Process Cellular Response To Peptide Hormone Stimulus Signal Transduction Response To Nutrient Levels Sphingolipid Floppase Activity Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Myosin II Filament Organization TMEM240-body Regulation Of Protein Localization Response To Formaldehyde Cellular Response To Vitamin B1 Peptidyl-serine Phosphorylation Positive Regulation Of Translational Initiation Regulation Of Establishment Of Protein Localization Protein Sumoylation Presynapse Spindle Response To Vitamin B3 Regulation Of Multicellular Organismal Process Regulation Of Transport Positive Regulation Of High-density Lipoprotein Particle Assembly Apolipoprotein A-I Receptor Activity Alpha-beta T Cell Differentiation Response To Hormone Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Cycle G1/S Phase Transition Cilium Regulation Of Cell Morphogenesis Regulation Of Cell Cycle Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Post-transcriptional Regulation Of Gene Expression
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