CDC25A and MAP3K5

Number of citations of the paper that reports this interaction (PMID 11416155)
18

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		CDC25A	MAP3K5
Gene Name		cell division cycle 25A	mitogen-activated protein kinase kinase kinase 5
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol	Endoplasmic Reticulum Cytosol Protein Kinase Complex
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Binding Protein Kinase Binding	Magnesium Ion Binding Protein Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Protein Kinase Binding Protein Phosphatase Binding Protein Homodimerization Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Mitotic Nuclear Division Cell Proliferation Response To Radiation Cellular Response To UV Peptidyl-tyrosine Dephosphorylation Cell Division Regulation Of Cell Cycle	MAPK Cascade Activation Of MAPKK Activity Response To Ischemia Protein Phosphorylation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process JNK Cascade Activation Of JUN Kinase Activity Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Viral Process Positive Regulation Of Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Innate Immune Response Cellular Response To Hydrogen Peroxide Apoptotic Signaling Pathway Programmed Necrotic Cell Death Positive Regulation Of Neuron Death Cellular Response To Reactive Nitrogen Species
Pathways		E2F mediated regulation of DNA replication Ubiquitin Mediated Degradation of Phosphorylated Cdc25A G2/M Checkpoints G2/M Transition G0 and Early G1 Cyclin E associated events during G1/S transition S Phase Cyclin B2 mediated events Cell Cycle, Mitotic Cyclin A/B1 associated events during G2/M transition G1/S Transition Activation of ATR in response to replication stress G1/S-Specific Transcription E2F-enabled inhibition of pre-replication complex formation p53-Independent DNA Damage Response Cell Cycle Checkpoints Cyclin A:Cdk2-associated events at S phase entry p53-Independent G1/S DNA damage checkpoint Mitotic G2-G2/M phases Mitotic G1-G1/S phases Polo-like kinase mediated events G1/S DNA Damage Checkpoints	Oxidative Stress Induced Senescence Cellular Senescence
Drugs
Diseases
GWAS
Protein-Protein Interactions		52 interactors: ANAPC11 APP AR BTRC CAMK1D CCNA1 CCNB1 CCNE1 CCNI CDK1 CDK2 CDKN3 CHEK1 CHEK2 CSNK1A1 CUL3 CUX1 DMD DUSP8 EEF1A1 EGFR FAM193B FBXW11 FGF21 FTH1 FZR1 HLA-C HRAS IL3RA LMO2 MAP3K5 MAPK14 MCM3AP MTAP NAA10 NFKBIB NFYA PEX19 PIM1 POLR1D RAF1 ROCK1 SCYL1 SMAD3 SOX5 UBB VAMP8 XPO1 YWHAB YWHAE YWHAQ YWHAZ	50 interactors: AKT1 AKT2 ARRB1 ARRB2 CDC25A CDKN1A CREBBP DAB2IP DAXX DMD DUSP19 EIF2AK2 EP300 ERN1 GADD45B GEMIN5 GLRX GSTM1 HSPA1A IGF1R JAK2 MAP2K4 MAP2K6 MAP2K7 MAP3K2 MAP3K3 MAP3K6 MAP3K7 MAPK8IP3 MBP NEDD4 NEDD4L PDCD6 PPP3R1 PPP5C PTPN11 QARS RAF1 SFN TNNT2 TPD52L1 TRAF2 TRAF5 TRAF6 TXN USP9X YWHAE YWHAH YWHAQ YWHAZ
Entrez ID		993	4217
HPRD ID		00305	03904
Ensembl ID		ENSG00000164045	ENSG00000197442
Uniprot IDs		P30304	Q99683
PDB IDs		1C25	2CLQ 3VW6 4BF2 4BHN 4BIB 4BIC 4BID 4BIE
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Mitotic Cell Cycle Process Regulation Of Protein Metabolic Process Cell Cycle Process Regulation Of Cell Cycle Cell Cycle Regulation Of Cellular Protein Metabolic Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Phosphorylation G1/S Transition Of Mitotic Cell Cycle Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Regulation Of Kinase Activity Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Phosphorylation Cellular Response To Organic Substance Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Intracellular Transport Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Apoptotic Process Regulation Of Cellular Component Organization Positive Regulation Of Transferase Activity Positive Regulation Of Gene Expression Apoptotic Signaling Pathway Programmed Cell Death Cellular Response To Growth Factor Stimulus Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cellular Biosynthetic Process Response To Growth Factor Cell Death Death Regulation Of Gene Expression Regulation Of Protein Catabolic Process Phosphate-containing Compound Metabolic Process Protein Phosphorylation Regulation Of Catalytic Activity Response To Stimulus Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription, DNA-templated Regulation Of Ubiquitin-protein Transferase Activity Cellular Protein Modification Process	Positive Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Signaling Positive Regulation Of Protein Kinase Activity Regulation Of Protein Kinase Activity Positive Regulation Of Phosphorylation Positive Regulation Of Kinase Activity Regulation Of Kinase Activity Regulation Of Phosphorylation Positive Regulation Of Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process Apoptotic Process Positive Regulation Of Transferase Activity Programmed Cell Death Positive Regulation Of Protein Modification Process Regulation Of Stress-activated MAPK Cascade Cell Death Death Regulation Of MAPK Cascade Positive Regulation Of Cellular Protein Metabolic Process Activation Of Protein Kinase Activity Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of JNK Cascade Response To Stress Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cell Death Regulation Of Intracellular Signal Transduction Regulation Of Catalytic Activity Regulation Of Apoptotic Process Cellular Response To Stress Positive Regulation Of Catalytic Activity Positive Regulation Of MAP Kinase Activity Positive Regulation Of Cellular Metabolic Process Positive Regulation Of JNK Cascade Positive Regulation Of Metabolic Process Cellular Response To Stimulus Response To Stimulus Intracellular Signal Transduction Positive Regulation Of JUN Kinase Activity Positive Regulation Of Programmed Cell Death Signal Transduction Signaling Positive Regulation Of Cell Death
Tagcloud ?		a2 abstract adenosine analog arrest blocks cdk2 chk2 contributes cordycepin cordyceps cytochrome cytosol erk1 exert inhibits initiates intrinsic involves leads militaris mitochondria nb obscure released sensitizes trigger u937 ways	199a2 angptl2 awry chondrosarcoma cmet discovering dnm3 evenly fibrosarcoma flt1 flt4 foxl1 genetics gli1 hif1alpha hmga2 kdr liposarcoma mdk med12 muc4 mycn osteocytes pcsk1 relentless sarcoma tek tie1 yeats4
Tagcloud (Difference) ?		a2 abstract adenosine analog arrest blocks cdk2 chk2 contributes cordycepin cordyceps cytochrome cytosol erk1 exert inhibits initiates intrinsic involves leads militaris mitochondria nb obscure released sensitizes trigger u937 ways	199a2 angptl2 awry chondrosarcoma cmet discovering dnm3 evenly fibrosarcoma flt1 flt4 foxl1 genetics gli1 hif1alpha hmga2 kdr liposarcoma mdk med12 muc4 mycn osteocytes pcsk1 relentless sarcoma tek tie1 yeats4
Tagcloud (Intersection) ?