CDC25A and CDKN3

Number of citations of the paper that reports this interaction (PMID 9989807)
27

Data Source:
HPRD (in vitro)

		CDC25A	CDKN3
Gene Name		cell division cycle 25A	cyclin-dependent kinase inhibitor 3
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol	Cytoplasm Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Binding Protein Kinase Binding	Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Mitotic Nuclear Division Cell Proliferation Response To Radiation Cellular Response To UV Peptidyl-tyrosine Dephosphorylation Cell Division Regulation Of Cell Cycle	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Cell Cycle Arrest Negative Regulation Of Cell Proliferation Peptidyl-tyrosine Dephosphorylation
Pathways		E2F mediated regulation of DNA replication Ubiquitin Mediated Degradation of Phosphorylated Cdc25A G2/M Checkpoints G2/M Transition G0 and Early G1 Cyclin E associated events during G1/S transition S Phase Cyclin B2 mediated events Cell Cycle, Mitotic Cyclin A/B1 associated events during G2/M transition G1/S Transition Activation of ATR in response to replication stress G1/S-Specific Transcription E2F-enabled inhibition of pre-replication complex formation p53-Independent DNA Damage Response Cell Cycle Checkpoints Cyclin A:Cdk2-associated events at S phase entry p53-Independent G1/S DNA damage checkpoint Mitotic G2-G2/M phases Mitotic G1-G1/S phases Polo-like kinase mediated events G1/S DNA Damage Checkpoints
Drugs
Diseases
GWAS			Dental caries ( 23259602) Working memory ( 21107309)
Protein-Protein Interactions		52 interactors: ANAPC11 APP AR BTRC CAMK1D CCNA1 CCNB1 CCNE1 CCNI CDK1 CDK2 CDKN3 CHEK1 CHEK2 CSNK1A1 CUL3 CUX1 DMD DUSP8 EEF1A1 EGFR FAM193B FBXW11 FGF21 FTH1 FZR1 HLA-C HRAS IL3RA LMO2 MAP3K5 MAPK14 MCM3AP MTAP NAA10 NFKBIB NFYA PEX19 PIM1 POLR1D RAF1 ROCK1 SCYL1 SMAD3 SOX5 UBB VAMP8 XPO1 YWHAB YWHAE YWHAQ YWHAZ	7 interactors: CDC25A CDK1 CDK2 CDK3 CEBPA MS4A3 NCOA3
Entrez ID		993	1033
HPRD ID		00305	00450
Ensembl ID		ENSG00000164045	ENSG00000100526
Uniprot IDs		P30304	F5H232 Q16667
PDB IDs		1C25	1FPZ 1FQ1
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Mitotic Cell Cycle Process Regulation Of Protein Metabolic Process Cell Cycle Process Regulation Of Cell Cycle Cell Cycle Regulation Of Cellular Protein Metabolic Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Phosphorylation G1/S Transition Of Mitotic Cell Cycle Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Regulation Of Kinase Activity Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Phosphorylation Cellular Response To Organic Substance Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Intracellular Transport Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Apoptotic Process Regulation Of Cellular Component Organization Positive Regulation Of Transferase Activity Positive Regulation Of Gene Expression Apoptotic Signaling Pathway Programmed Cell Death Cellular Response To Growth Factor Stimulus Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cellular Biosynthetic Process Response To Growth Factor Cell Death Death Regulation Of Gene Expression Regulation Of Protein Catabolic Process Phosphate-containing Compound Metabolic Process Protein Phosphorylation Regulation Of Catalytic Activity Response To Stimulus Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription, DNA-templated Regulation Of Ubiquitin-protein Transferase Activity Cellular Protein Modification Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Nuclear Division Regulation Of Cell Cycle Cell Division G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Process Mitotic Cell Cycle Organelle Organization DNA Replication Histone Phosphorylation Cell Cycle Process Centrosome Cycle Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Histone Modification Positive Regulation Of DNA Replication Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Organ Regeneration Response To Inorganic Substance Regulation Of Ubiquitin-protein Transferase Activity Pronuclear Fusion Cell Cycle Mitotic DNA Damage Checkpoint Centrosome Organization Mitotic DNA Integrity Checkpoint Cellular Response To Reactive Oxygen Species Microtubule Organizing Center Organization Positive Regulation Of Macromolecule Biosynthetic Process Embryonic Placenta Development Positive Regulation Of Gene Expression Chromatin Modification Regulation Of DNA Replication G0 To G1 Transition Positive Regulation Of Cellular Biosynthetic Process Cellular Response To Inorganic Substance Cellular Protein Modification Process Positive Regulation Of DNA Metabolic Process DNA Damage Checkpoint Chromatin Organization Mitotic Cell Cycle Checkpoint Response To Vitamin B2 Positive Regulation Of DNA-dependent DNA Replication Initiation Cellular Macromolecule Biosynthetic Process Placenta Development Response To Reactive Oxygen Species Receptor Transactivation Macromolecule Biosynthetic Process Cellular Response To Oxidative Stress Regulation Of Protein Ubiquitination
Tagcloud ?		a2 abstract adenosine analog arrest blocks cdk2 chk2 contributes cordycepin cordyceps cytochrome cytosol erk1 exert inhibits initiates intrinsic involves leads militaris mitochondria nb obscure released sensitizes trigger u937 ways	aberrantly anaplastic atc atcs axin1 braf cdki cdkn1a cdkn1b cdkn2a cdkn2b cdkn2c ctnnb1 exclusivity ink4b ink4c mutational mutual p14 p15 p18 pdtc pdtcs pik3ca profiled snai2 spliced spot underexpression
Tagcloud (Difference) ?		a2 abstract adenosine analog arrest blocks cdk2 chk2 contributes cordycepin cordyceps cytochrome cytosol erk1 exert inhibits initiates intrinsic involves leads militaris mitochondria nb obscure released sensitizes trigger u937 ways	aberrantly anaplastic atc atcs axin1 braf cdki cdkn1a cdkn1b cdkn2a cdkn2b cdkn2c ctnnb1 exclusivity ink4b ink4c mutational mutual p14 p15 p18 pdtc pdtcs pik3ca profiled snai2 spliced spot underexpression
Tagcloud (Intersection) ?