CDC25A and MTAP

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		CDC25A	MTAP
Name		cell division cycle 25A	methylthioadenosine phosphorylase
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Protein Kinase Binding Protein-folding Chaperone Binding	Catalytic Activity 1,4-alpha-oligoglucan Phosphorylase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Pentosyltransferase Activity S-methyl-5-thioadenosine Phosphorylase Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Nuclear Envelope Organization Mitotic Nuclear Membrane Disassembly Cell Population Proliferation Response To Radiation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of DNA Replication Cell Division Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle Positive Regulation Of Cell Cycle G2/M Phase Transition	Nucleobase-containing Compound Metabolic Process Purine Ribonucleoside Salvage Nicotinamide Riboside Catabolic Process Nucleoside Metabolic Process L-methionine Salvage From Methylthioadenosine Methylation Response To Testosterone
Pathways		Transcription of E2F targets under negative control by DREAM complex Polo-like kinase mediated events Activation of ATR in response to replication stress Ub-specific processing proteases Cyclin E associated events during G1/S transition Cyclin A/B1/B2 associated events during G2/M transition Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Cyclin A:Cdk2-associated events at S phase entry Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	Methionine salvage pathway Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs		None	Adenine (2S,3S,4R,5S)-2-(4-Amino-4,5-dihydro-1H-pyrrolo[3,2-d]pyrimidin-7-yl)-5-[(methylsulfanyl)methyl]-3,4-pyrrolidinediol Formycin 5'-S-methyl-5'-thioadenosine 5'-Deoxy-5'-(Methylthio)-Tubercidin
GWAS		A body shape index ( 34021172 ) Body size at age 10 ( 32376654 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Coronary artery disease ( 29212778 ) Cortical surface area (MOSTest) ( 32665545 ) Diastolic blood pressure ( 27841878 ) HDL cholesterol levels ( 32203549 ) Household income (MTAG) ( 31844048 ) Loneliness (multivariate analysis) ( 27629369 ) Medication use (agents acting on the renin-angiotensin system) ( 31015401 ) Medication use (beta blocking agents) ( 31015401 ) Medication use (diuretics) ( 31015401 ) Pulse pressure ( 27841878 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Systolic blood pressure ( 27841878 27618447 ) Waist circumference adjusted for body mass index ( 34021172 )	Adverse response to drug ( 30420678 ) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682 ) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444 ) Coronary heart disease ( 21606135 ) Cutaneous malignant melanoma ( 32341527 ) Cutaneous nevi ( 19578365 ) Diastolic blood pressure ( 28135244 ) Diastolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415 ) Glycated hemoglobin levels ( 28898252 ) Lung adenocarcinoma ( 28604730 ) Lung cancer ( 28604730 ) Lung cancer in never smokers ( 28604730 ) Lung function in heavy smokers (low FEV1 vs high FEV1) ( 26423011 ) Macular thickness ( 30535121 ) Mean spheric corpuscular volume ( 32888494 ) Melanoma ( 28212542 21983787 ) Nevus count ( 30429480 ) Nevus count or cutaneous melanoma ( 30429480 32341527 ) Pediatric bone mineral content (radius) ( 26041818 ) Pulse pressure ( 28135244 )
Novel Interactors		2 novel interactors: CCR1 CTNNB1	2 novel interactors: PKD2 PLCB2
Interacting Genes		57 interacting genes: APP AR BTRC CAMK1D CCNA1 CCNB1 CCNE1 CCNI CDK1 CDK2 CDK5 CDKN3 CHEK1 CHEK2 CSNK1A1 CUL3 CUX1 DMD DUSP8 EEF1A1 EGFR EP300 FAM193B FBXW11 FGF21 FTH1 HDAC11 HLA-C HRAS IL3RA LMO2 MAP3K5 MAPK14 MCM3AP MTAP NAA10 NAA11 NFKBIB NFYA PEX19 PIM1 PIN1 PKM POLR1D RAF1 ROCK1 SCYL1 SMAD3 SOX5 SRC UBB VAMP8 XPO1 YWHAB YWHAE YWHAQ YWHAZ	7 interacting genes: CDC25A CENPH EMC3 FOLH1 LYRM1 MYLIP RELB
Entrez ID		993	4507
HPRD ID		00305	01134
Ensembl ID		ENSG00000164045	ENSG00000099810
Uniprot IDs		D8KXX0 K7N7S0 P30304	A0A384ME80 B4DUC8 Q13126
PDB IDs		1C25 8ROZ	1CB0 1CG6 1K27 1SD1 1SD2 3LN5 3OZC 3OZD 3OZE 5EUB 5TC5 5TC6 5TC7 5TC8 6DYZ 6DZ0 6DZ2 6DZ3
GO Terms Enriched among Interactors		Nucleus Cytosol Cytoplasm Intracellular Signaling Cassette Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Mitotic Cell Cycle Phase Transition Protein Kinase Activity Regulation Of Cell Cycle Kinase Activity Cell Cycle Phase Transition Regulation Of RNA Metabolic Process Cellular Response To Oxygen-containing Compound Regulation Of Nucleobase-containing Compound Metabolic Process MAPK Cascade G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Protein Localization Phosphoserine Residue Binding Regulation Of Primary Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Serine Kinase Activity Regulation Of Protein Localization To Nucleus Regulation Of Macromolecule Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Catabolic Process Regulation Of Nucleocytoplasmic Transport Protein Serine/threonine Kinase Activity Positive Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Gene Expression Signal Transduction Regulation Of Cellular Localization Protein Phosphorylation Regulation Of Macromolecule Biosynthetic Process Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of MAPK Cascade Regulation Of Cellular Component Organization Regulation Of Intracellular Protein Transport Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Modification Process Regulation Of TORC1 Signaling	Intestinal Folate Absorption Tetrahydrofolyl-poly(glutamate) Polymer Binding Ac-Asp-Glu Binding Release Of Sequestered Calcium Ion Into Cytosol Metanephric Cortical Collecting Duct Development Cellular Response To Osmotic Stress Metanephric Cortex Development Metanephric Distal Tubule Development Negative Regulation Of Sequestering Of Calcium Ion G-protein Beta/gamma-subunit Complex Cytoskeletal Protein Binding Response To Osmotic Stress Calcium Ion Transmembrane Import Into Cytosol Polycystin Complex Metanephric Smooth Muscle Tissue Development Renal Artery Morphogenesis Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle Metanephric Part Of Ureteric Bud Development Regulation Of Sequestering Of Calcium Ion Migrasome Metanephric Ascending Thin Limb Development Distal Tubule Development Cellular Response To Hydrostatic Pressure HLH Domain Binding Metanephric S-shaped Body Morphogenesis Detection Of Nodal Flow NF-kappaB Complex Calcium-induced Calcium Release Activity Basal Cortex Nephric Duct Development Mesonephric Duct Development Sensory Perception Of Bitter Taste Glutamate Biosynthetic Process S-shaped Body Morphogenesis Determination Of Liver Left/right Asymmetry Response To Hydrostatic Pressure Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Kinetochore Binding Regulation Of G2/MI Transition Of Meiotic Cell Cycle Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Metanephric Mesenchyme Development Phosphatidylinositol Phospholipase C Activity