CDC25A and CCNI

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		CDC25A	CCNI
Name		cell division cycle 25A	cyclin I
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Cytoplasm Membrane Nuclear Membrane
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Protein Kinase Binding Protein-folding Chaperone Binding	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Nuclear Envelope Organization Mitotic Nuclear Membrane Disassembly Cell Population Proliferation Response To Radiation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of DNA Replication Cell Division Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle Positive Regulation Of Cell Cycle G2/M Phase Transition	G1/S Transition Of Mitotic Cell Cycle Spermatogenesis
Pathways		Transcription of E2F targets under negative control by DREAM complex Polo-like kinase mediated events Activation of ATR in response to replication stress Ub-specific processing proteases Cyclin E associated events during G1/S transition Cyclin A/B1/B2 associated events during G2/M transition Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Cyclin A:Cdk2-associated events at S phase entry Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	None
GWAS		A body shape index ( 34021172 ) Body size at age 10 ( 32376654 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Coronary artery disease ( 29212778 ) Cortical surface area (MOSTest) ( 32665545 ) Diastolic blood pressure ( 27841878 ) HDL cholesterol levels ( 32203549 ) Household income (MTAG) ( 31844048 ) Loneliness (multivariate analysis) ( 27629369 ) Medication use (agents acting on the renin-angiotensin system) ( 31015401 ) Medication use (beta blocking agents) ( 31015401 ) Medication use (diuretics) ( 31015401 ) Pulse pressure ( 27841878 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Systolic blood pressure ( 27841878 27618447 ) Waist circumference adjusted for body mass index ( 34021172 )	No GWAS studies recorded
Interacting Genes		57 interacting genes: APP AR BTRC CAMK1D CCNA1 CCNB1 CCNE1 CCNI CDK1 CDK2 CDK5 CDKN3 CHEK1 CHEK2 CSNK1A1 CUL3 CUX1 DMD DUSP8 EEF1A1 EGFR EP300 FAM193B FBXW11 FGF21 FTH1 HDAC11 HLA-C HRAS IL3RA LMO2 MAP3K5 MAPK14 MCM3AP MTAP NAA10 NAA11 NFKBIB NFYA PEX19 PIM1 PIN1 PKM POLR1D RAF1 ROCK1 SCYL1 SMAD3 SOX5 SRC UBB VAMP8 XPO1 YWHAB YWHAE YWHAQ YWHAZ	10 interacting genes: AKT1 CDC25A CDK3 CDK6 CEP63 IL1RAP KRT18 MSRA RND1 ZMYND19
Entrez ID		993	10983
HPRD ID		00305	16690
Ensembl ID		ENSG00000164045	ENSG00000118816
Uniprot IDs		D8KXX0 K7N7S0 P30304	Q14094
PDB IDs		1C25 8ROZ	Not available
GO Terms Enriched among Interactors		Nucleus Cytosol Cytoplasm Intracellular Signaling Cassette Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Mitotic Cell Cycle Phase Transition Protein Kinase Activity Regulation Of Cell Cycle Kinase Activity Cell Cycle Phase Transition Regulation Of RNA Metabolic Process Cellular Response To Oxygen-containing Compound Regulation Of Nucleobase-containing Compound Metabolic Process MAPK Cascade G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Protein Localization Phosphoserine Residue Binding Regulation Of Primary Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Serine Kinase Activity Regulation Of Protein Localization To Nucleus Regulation Of Macromolecule Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Catabolic Process Regulation Of Nucleocytoplasmic Transport Protein Serine/threonine Kinase Activity Positive Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Gene Expression Signal Transduction Regulation Of Cellular Localization Protein Phosphorylation Regulation Of Macromolecule Biosynthetic Process Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of MAPK Cascade Regulation Of Cellular Component Organization Regulation Of Intracellular Protein Transport Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Modification Process Regulation Of TORC1 Signaling	Regulation Of Cell Cycle Phase Transition Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Mitotic Cell Cycle Phase Transition Cell Division Cell Cycle Phase Transition Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Mitotic Cell Cycle Cyclin Binding Regulation Of Cell Cycle Golgi To Plasma Membrane Protein Transport Negative Regulation Of Notch Signaling Pathway Cyclin-dependent Protein Kinase Holoenzyme Complex Establishment Of Protein Localization To Plasma Membrane Regulation Of TRNA Methylation Golgi To Plasma Membrane Transport Cyclin D2-CDK6 Complex L-methionine:thioredoxin-disulfide S-oxidoreductase Activity Peptide-methionine (S)-S-oxide Reductase Activity L-methionine-(S)-S-oxide Reductase Activity Negative Regulation Of Protein Ubiquitination Cellular Response To Stress Protein Serine Kinase Activity Negative Regulation Of Protein Localization To Lysosome Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Interleukin-33 Receptor Activity Negative Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Localization To Endoplasmic Reticulum Cytokine-mediated Signaling Pathway Regulation Of Notch Signaling Pathway Post-Golgi Vesicle-mediated Transport Response To Insulin-like Growth Factor Stimulus Positive Regulation Of Mitotic Cell Cycle Phase Transition Mammalian Oogenesis Stage TRNA (guanine-N7)-methylation Cellular Response To Rapamycin Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Protein Serine/threonine Kinase Activity Positive Regulation Of Endodeoxyribonuclease Activity Positive Regulation Of G2/MI Transition Of Meiotic Cell Cycle Positive Regulation Of Cell Cycle Phase Transition Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Protein Kinase Binding TORC2 Complex Binding