CDC25A and ROCK1

Number of citations of the paper that reports this interaction (PMID 14657354)
23

Data Source:
HPRD (in vitro, in vivo)

		CDC25A	ROCK1
Gene Name		cell division cycle 25A	Rho-associated, coiled-coil containing protein kinase 1
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol	Golgi Membrane Ruffle Centriole Cytosol Cytoskeleton Plasma Membrane Lamellipodium Bleb
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Binding Protein Kinase Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding GTP-Rho Binding Metal Ion Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Mitotic Nuclear Division Cell Proliferation Response To Radiation Cellular Response To UV Peptidyl-tyrosine Dephosphorylation Cell Division Regulation Of Cell Cycle	Apical Constriction Protein Phosphorylation Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Smooth Muscle Contraction Leukocyte Cell-cell Adhesion Signal Transduction Rho Protein Signal Transduction Axon Guidance Negative Regulation Of Angiogenesis Membrane To Membrane Docking Actin Cytoskeleton Organization Regulation Of Cell Adhesion Bleb Assembly Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Neuron Apoptotic Process Regulation Of Keratinocyte Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Leukocyte Migration Leukocyte Tethering Or Rolling Myoblast Migration Regulation Of Stress Fiber Assembly Regulation Of Focal Adhesion Assembly Positive Regulation Of Focal Adhesion Assembly Regulation Of Establishment Of Cell Polarity Regulation Of Cell Motility
Pathways		E2F mediated regulation of DNA replication Ubiquitin Mediated Degradation of Phosphorylated Cdc25A G2/M Checkpoints G2/M Transition G0 and Early G1 Cyclin E associated events during G1/S transition S Phase Cyclin B2 mediated events Cell Cycle, Mitotic Cyclin A/B1 associated events during G2/M transition G1/S Transition Activation of ATR in response to replication stress G1/S-Specific Transcription E2F-enabled inhibition of pre-replication complex formation p53-Independent DNA Damage Response Cell Cycle Checkpoints Cyclin A:Cdk2-associated events at S phase entry p53-Independent G1/S DNA damage checkpoint Mitotic G2-G2/M phases Mitotic G1-G1/S phases Polo-like kinase mediated events G1/S DNA Damage Checkpoints	Signaling by GPCR Apoptotic cleavage of cellular proteins Axon guidance Semaphorin interactions Apoptotic execution phase VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling EPHA-mediated growth cone collapse GPCR downstream signaling Signaling by VEGF Programmed Cell Death EPH-Ephrin signaling G alpha (12/13) signalling events Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse
Drugs			HYDROXYFASUDIL (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE (R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDE
Diseases
GWAS
Protein-Protein Interactions		52 interactors: ANAPC11 APP AR BTRC CAMK1D CCNA1 CCNB1 CCNE1 CCNI CDK1 CDK2 CDKN3 CHEK1 CHEK2 CSNK1A1 CUL3 CUX1 DMD DUSP8 EEF1A1 EGFR FAM193B FBXW11 FGF21 FTH1 FZR1 HLA-C HRAS IL3RA LMO2 MAP3K5 MAPK14 MCM3AP MTAP NAA10 NFKBIB NFYA PEX19 PIM1 POLR1D RAF1 ROCK1 SCYL1 SMAD3 SOX5 UBB VAMP8 XPO1 YWHAB YWHAE YWHAQ YWHAZ	32 interactors: ADD1 ARHGAP24 C6orf165 CASP3 CASP7 CDC25A CDC34 CRMP1 DES DPYSL2 EZR FAM124A GFAP IKBKB IRS1 ITSN2 LIMK1 LIMK2 LMO2 MAGEB4 MSN PFN2 POLR3C PPP1R12A PTK2 RDX RHOA RHOC RND3 SMAD2 TSG101 VIM
Entrez ID		993	6093
HPRD ID		00305	03414
Ensembl ID		ENSG00000164045
Uniprot IDs		P30304	Q13464
PDB IDs		1C25	1S1C 2ESM 2ETK 2ETR 2V55 3D9V 3NCZ 3NDM 3O0Z 3TV7 3TWJ 3V8S
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Mitotic Cell Cycle Process Regulation Of Protein Metabolic Process Cell Cycle Process Regulation Of Cell Cycle Cell Cycle Regulation Of Cellular Protein Metabolic Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Phosphorylation G1/S Transition Of Mitotic Cell Cycle Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Regulation Of Kinase Activity Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Phosphorylation Cellular Response To Organic Substance Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Intracellular Transport Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Apoptotic Process Regulation Of Cellular Component Organization Positive Regulation Of Transferase Activity Positive Regulation Of Gene Expression Apoptotic Signaling Pathway Programmed Cell Death Cellular Response To Growth Factor Stimulus Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cellular Biosynthetic Process Response To Growth Factor Cell Death Death Regulation Of Gene Expression Regulation Of Protein Catabolic Process Phosphate-containing Compound Metabolic Process Protein Phosphorylation Regulation Of Catalytic Activity Response To Stimulus Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription, DNA-templated Regulation Of Ubiquitin-protein Transferase Activity Cellular Protein Modification Process	Regulation Of Cellular Component Organization Cytoskeleton Organization Negative Regulation Of Cell Projection Organization Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Execution Phase Of Apoptosis Cell Development Regulation Of Cell Projection Organization Cell Differentiation Positive Regulation Of Metabolic Process Epithelium Development Axon Guidance Movement Of Cell Or Subcellular Component Actin Filament-based Process Organelle Organization Regulation Of Cellular Process Anatomical Structure Development Cell Morphogenesis Involved In Differentiation Skeletal Muscle Satellite Cell Migration Axonogenesis Cell Morphogenesis Neuron Projection Development Axon Development Neuron Differentiation System Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Neuron Projection Development Cell Projection Organization Response To Stimulus Response To Growth Factor Establishment Of Endothelial Barrier Chemotaxis Regulation Of Metabolic Process Developmental Process Enzyme Linked Receptor Protein Signaling Pathway Generation Of Neurons Neuron Projection Morphogenesis Negative Regulation Of Neuron Projection Development Locomotion Neuron Development Wound Healing, Spreading Of Cells Neurogenesis Negative Regulation Of Ruffle Assembly Membrane To Membrane Docking Tissue Development Bergmann Glial Cell Differentiation Positive Regulation Of Stress Fiber Assembly Regulation Of Cytoskeleton Organization Multicellular Organismal Development Endothelial Cell Development Positive Regulation Of Actin Filament Bundle Assembly
Tagcloud ?		a2 abstract adenosine analog arrest blocks cdk2 chk2 contributes cordycepin cordyceps cytochrome cytosol erk1 exert inhibits initiates intrinsic involves leads militaris mitochondria nb obscure released sensitizes trigger u937 ways	angiogenic au contributor decay disperse dispersion ecs eliciting gtpase herpesvirus hsp27 kapb kaposi kaposin ks kshv latently likewise mk2 p115rhogef pb pbs reprogramming restore rhoa ribonucleoprotein sarcoma secrete secretory
Tagcloud (Difference) ?		a2 abstract adenosine analog arrest blocks cdk2 chk2 contributes cordycepin cordyceps cytochrome cytosol erk1 exert inhibits initiates intrinsic involves leads militaris mitochondria nb obscure released sensitizes trigger u937 ways	angiogenic au contributor decay disperse dispersion ecs eliciting gtpase herpesvirus hsp27 kapb kaposi kaposin ks kshv latently likewise mk2 p115rhogef pb pbs reprogramming restore rhoa ribonucleoprotein sarcoma secrete secretory
Tagcloud (Intersection) ?