CDC25A and FGF21

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CDC25A	FGF21
Gene Name		cell division cycle 25A	fibroblast growth factor 21
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytosol	Extracellular Region
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Binding Protein Kinase Binding	Fibroblast Growth Factor Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Mitotic Nuclear Division Cell Proliferation Response To Radiation Cellular Response To UV Peptidyl-tyrosine Dephosphorylation Cell Division Regulation Of Cell Cycle	Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Proliferation Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Positive Regulation Of Glucose Import Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway
Pathways		E2F mediated regulation of DNA replication Ubiquitin Mediated Degradation of Phosphorylated Cdc25A G2/M Checkpoints G2/M Transition G0 and Early G1 Cyclin E associated events during G1/S transition S Phase Cyclin B2 mediated events Cell Cycle, Mitotic Cyclin A/B1 associated events during G2/M transition G1/S Transition Activation of ATR in response to replication stress G1/S-Specific Transcription E2F-enabled inhibition of pre-replication complex formation p53-Independent DNA Damage Response Cell Cycle Checkpoints Cyclin A:Cdk2-associated events at S phase entry p53-Independent G1/S DNA damage checkpoint Mitotic G2-G2/M phases Mitotic G1-G1/S phases Polo-like kinase mediated events G1/S DNA Damage Checkpoints
Drugs
Diseases
GWAS			Bipolar disorder ( 21926972) Dietary macronutrient intake ( 23372041 23636237) Retinal vascular caliber ( 21060863)
Protein-Protein Interactions		52 interactors: ANAPC11 APP AR BTRC CAMK1D CCNA1 CCNB1 CCNE1 CCNI CDK1 CDK2 CDKN3 CHEK1 CHEK2 CSNK1A1 CUL3 CUX1 DMD DUSP8 EEF1A1 EGFR FAM193B FBXW11 FGF21 FTH1 FZR1 HLA-C HRAS IL3RA LMO2 MAP3K5 MAPK14 MCM3AP MTAP NAA10 NFKBIB NFYA PEX19 PIM1 POLR1D RAF1 ROCK1 SCYL1 SMAD3 SOX5 UBB VAMP8 XPO1 YWHAB YWHAE YWHAQ YWHAZ	5 interactors: CDC25A CDH7 KLB MAPK7 NEDD4
Entrez ID		993	26291
HPRD ID		00305	09447
Ensembl ID		ENSG00000164045	ENSG00000105550
Uniprot IDs		P30304	Q9NSA1
PDB IDs		1C25
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Mitotic Cell Cycle Process Regulation Of Protein Metabolic Process Cell Cycle Process Regulation Of Cell Cycle Cell Cycle Regulation Of Cellular Protein Metabolic Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Phosphorylation G1/S Transition Of Mitotic Cell Cycle Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Regulation Of Kinase Activity Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Phosphorylation Cellular Response To Organic Substance Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Intracellular Transport Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Apoptotic Process Regulation Of Cellular Component Organization Positive Regulation Of Transferase Activity Positive Regulation Of Gene Expression Apoptotic Signaling Pathway Programmed Cell Death Cellular Response To Growth Factor Stimulus Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cellular Biosynthetic Process Response To Growth Factor Cell Death Death Regulation Of Gene Expression Regulation Of Protein Catabolic Process Phosphate-containing Compound Metabolic Process Protein Phosphorylation Regulation Of Catalytic Activity Response To Stimulus Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription, DNA-templated Regulation Of Ubiquitin-protein Transferase Activity Cellular Protein Modification Process	Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Cellular Response To UV Cellular Response To Light Stimulus Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Transmission Of Virus Development Involved In Symbiotic Interaction Response To UV Cellular Response To Radiation Negative Regulation Of CAMP Catabolic Process Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Progesterone Receptor Signaling Pathway Negative Regulation Of NFAT Protein Import Into Nucleus Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Immune Response Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Heterotypic Cell-cell Adhesion Positive Regulation Of MAPKKK Cascade By Fibroblast Growth Factor Receptor Signaling Pathway Glucocorticoid Receptor Signaling Pathway Response To Light Stimulus Regulation Of Phosphorus Metabolic Process Protein Targeting To Lysosome Negative Regulation Of Sodium Ion Transport Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Transport Protein Localization To Lysosome Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Intracellular Transport Response To Radiation Cellular Response To Fluid Shear Stress Response To Laminar Fluid Shear Stress Regulation Of Intracellular Signal Transduction Immune Response-regulating Signaling Pathway Response To Inorganic Substance Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Receptor Catabolic Process Cellular Response To Organic Substance Single Organismal Cell-cell Adhesion Protein Targeting To Vacuole CAMP-mediated Signaling Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Negative Regulation Of Endothelial Cell Apoptotic Process Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Establishment Of Protein Localization To Vacuole Cellular Response To Growth Factor Stimulus Negative Regulation Of Oxidative Stress-induced Cell Death Regulation Of Potassium Ion Transmembrane Transporter Activity
Tagcloud ?		a2 abstract adenosine analog arrest blocks cdk2 chk2 contributes cordycepin cordyceps cytochrome cytosol erk1 exert inhibits initiates intrinsic involves leads militaris mitochondria nb obscure released sensitizes trigger u937 ways	1alpha 3beta akt1 akt2 ampk blots deletion diabetic exacerbates exacerbating examining fatty fibroblast germ gs gsk inactivated ko maintaining pgc protects reflected sirt1 spermatogenesis streptozotocin testes testicular tried
Tagcloud (Difference) ?		a2 abstract adenosine analog arrest blocks cdk2 chk2 contributes cordycepin cordyceps cytochrome cytosol erk1 exert inhibits initiates intrinsic involves leads militaris mitochondria nb obscure released sensitizes trigger u937 ways	1alpha 3beta akt1 akt2 ampk blots deletion diabetic exacerbates exacerbating examining fatty fibroblast germ gs gsk inactivated ko maintaining pgc protects reflected sirt1 spermatogenesis streptozotocin testes testicular tried
Tagcloud (Intersection) ?