CEP350 and APTX

Number of citations of the paper that reports this interaction (PMID 16713569)
214

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CEP350	APTX
Gene Name		centrosomal protein 350kDa	aprataxin
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Centrosome Spindle Membrane	Chromatin Nuclear Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm
	Molecular Function	Protein Binding Microtubule Binding	Chromatin Binding Damaged DNA Binding Double-stranded DNA Binding Double-stranded RNA Binding Protein Binding Phosphoglycolate Phosphatase Activity DNA 5'-adenosine Monophosphate Hydrolase Activity Polynucleotide 3'-phosphatase Activity Metal Ion Binding Protein N-terminus Binding Phosphoprotein Binding
	Biological Process	Microtubule Anchoring	Single Strand Break Repair DNA Catabolic Process, Exonucleolytic DNA Ligation Double-strand Break Repair Cellular Response To DNA Damage Stimulus Dephosphorylation Regulation Of Protein Stability Response To Hydrogen Peroxide Polynucleotide 3' Dephosphorylation
Pathways
Drugs
Diseases
GWAS		Anorexia nervosa ( 23568457)
Protein-Protein Interactions		6 interactors: APTX NR1H3 PLEKHA5 PPARA PPARD PPARG	16 interactors: CALCOCO1 CEP350 CNTROB HIVEP1 MAPKBP1 MBP PARP1 PICK1 PNMA1 SYT17 TP53 TRIM37 TSPYL2 XRCC1 XRCC4 ZNF639
Entrez ID		9857	54840
HPRD ID		09870	05892
Ensembl ID		ENSG00000135837	ENSG00000137074
Uniprot IDs		Q5VT06	Q7Z2E3
PDB IDs		2COZ	3KT9
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cholesterol Storage Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Receptor Biosynthetic Process Negative Regulation Of Lipid Storage Hormone-mediated Signaling Pathway Positive Regulation Of Fatty Acid Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Lipid Storage Fatty Acid Transport Negative Regulation Of Collagen Biosynthetic Process Negative Regulation Of Receptor Biosynthetic Process Negative Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Fatty Acid Metabolic Process Negative Regulation Of Multicellular Organismal Metabolic Process Cellular Response To Organic Cyclic Compound Regulation Of Lipid Transport Negative Regulation Of Sequestering Of Triglyceride Regulation Of Circadian Rhythm Cellular Response To Lipid Negative Regulation Of Inflammatory Response Response To Steroid Hormone Monocarboxylic Acid Transport Positive Regulation Of Fatty Acid Oxidation Cellular Response To Hormone Stimulus Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Vitamin A Regulation Of Fatty Acid Oxidation Response To Lipid Transcription From RNA Polymerase II Promoter Response To Organic Cyclic Compound Regulation Of Inflammatory Response Regulation Of Collagen Metabolic Process Response To Hormone Regulation Of Cholesterol Transport Negative Regulation Of Innate Immune Response Negative Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Lipid Metabolic Process Cellular Lipid Metabolic Process Lipid Transport Carboxylic Acid Transport Organic Acid Transport Negative Regulation Of Response To Cytokine Stimulus Fatty Acid Metabolic Process	Base-excision Repair Negative Regulation Of Biosynthetic Process Double-strand Break Repair Cellular Response To Glucose Starvation Response To X-ray Cellular Response To Stress DNA Metabolic Process Negative Regulation Of DNA Replication Negative Regulation Of Transcription, DNA-templated DNA Repair Negative Regulation Of Nucleic Acid-templated Transcription Response To Stress Response To Gamma Radiation Regulation Of Growth Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Component Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process T Cell Differentiation In Thymus Negative Regulation Of Gene Expression Leukocyte Differentiation Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Growth Negative Regulation Of Macromitophagy Oligodendrocyte Apoptotic Process Cellular Response To DNA Damage Stimulus Negative Regulation Of DNA Metabolic Process Regulation Of Fibroblast Proliferation Transcription, DNA-templated Cellular Response To Decreased Oxygen Levels Defense Response To Nematode Protein Poly-ADP-ribosylation Negative Regulation Of Helicase Activity Regulation Of Growth Rate Histone H2A-K119 Monoubiquitination ER-nucleus Signaling Pathway RNA Biosynthetic Process Cellular Response To Oxygen Levels Nitrogen Compound Metabolic Process Negative Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Regulation Of DNA Replication Response To Inorganic Substance Positive Regulation Of Transcription From RNA Polymerase II Promoter Chromosome Organization Positive Regulation Of Cellular Metabolic Process
Tagcloud ?			accelerated adenylated ageing aprataxin apraxia ataxia breaks cerebellar deregulation dismutase doubling envelope g93a hallmark hallmarks invaginations k9 nucleic oculomotor organismal premature resolving silenced sod1 surviving systemically triggering uncovers vertebrates
Tagcloud (Difference) ?			accelerated adenylated ageing aprataxin apraxia ataxia breaks cerebellar deregulation dismutase doubling envelope g93a hallmark hallmarks invaginations k9 nucleic oculomotor organismal premature resolving silenced sod1 surviving systemically triggering uncovers vertebrates
Tagcloud (Intersection) ?