CEP350 and APTX

Number of citations: 0 (PubMedID 16713569)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		CEP350	APTX
Name		centrosomal protein 350	aprataxin
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Centriole Spindle Cytosol Cytoskeleton Membrane Ciliary Basal Body Cell Projection	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm
	Molecular Function	Protein Binding Microtubule Binding	DNA Binding Chromatin Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Double-stranded RNA Binding Catalytic Activity Protein Binding Zinc Ion Binding Phosphoglycolate Phosphatase Activity Hydrolase Activity Mismatched DNA Binding DNA 5'-adenosine Monophosphate Hydrolase Activity Polynucleotide 3'-phosphatase Activity Metal Ion Binding Phosphoprotein Binding DNA-3'-diphospho-5'-guanosine Diphosphatase Single-strand Break-containing DNA Binding
	Biological Process	Microtubule Anchoring Protein Localization To Centrosome Non-motile Cilium Assembly	Single Strand Break Repair DNA Repair DNA Damage Response Regulation Of Protein Stability
Diseases		None	Ataxia with ocular apraxia (AOA), including: Ataxia telangiectasia (AT); Ataxia telangiectasia like disorder (ATLD); Ataxia oculomotor apraxia type 1 (AOA1); Ataxia oculomotor apraxia type 2 (AOA2) Coenzyme Q10 deficiency
GWAS		Anorexia nervosa ( 23568457 ) Mean corpuscular volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Smoking initiation ( 30617275 )	Height ( 28552196 ) Menopause (age at onset) ( 26414677 )
Novel Interactors		4 novel interactors: ADIPOR1 APH1A ID3 RSRP1	None recorded
Interacting Genes		7 interacting genes: APP APTX NR1H3 PLEKHA5 PPARA PPARD PPARG	18 interacting genes: CALCOCO1 CEP350 CNTROB FLAD1 HIVEP1 MAPKBP1 MBP PARP1 PICK1 PNMA1 PNMA3 SYT17 TP53 TRIM37 TSPYL2 XRCC1 XRCC4 ZNF639
Entrez ID		9857	54840
HPRD ID		09870	05892
Ensembl ID		ENSG00000135837	ENSG00000137074
Uniprot IDs		Q5T2X4 Q5VT06	A0A5K1VW64 Q7Z2E3
PDB IDs		2COZ	3KT9 4NDF 4NDG 4NDH 4NDI 6CVO 6CVP 6CVQ 6CVR 6CVS 6CVT
GO Terms Enriched among Interactors		Negative Regulation Of Cholesterol Storage Negative Regulation Of Lipid Storage Negative Regulation Of MiRNA Transcription Positive Regulation Of Fatty Acid Metabolic Process Regulation Of Small Molecule Metabolic Process Hormone-mediated Signaling Pathway Regulation Of Lipid Storage Nuclear Receptor Activity Positive Regulation Of Small Molecule Metabolic Process Negative Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Regulation Of Fatty Acid Metabolic Process Regulation Of Lipid Metabolic Process Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Ketone Metabolic Process RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Lipid Metabolic Process Negative Regulation Of Cell Differentiation Regulation Of Inflammatory Response Negative Regulation Of Inflammatory Response Cellular Response To Oxygen-containing Compound Negative Regulation Of Type II Interferon-mediated Signaling Pathway Intracellular Receptor Signaling Pathway Negative Regulation Of Developmental Process Regulation Of Cell Differentiation Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Defense Response Peroxisome Proliferator Activated Receptor Signaling Pathway Fatty Acid Metabolic Process Regulation Of Type II Interferon-mediated Signaling Pathway Regulation Of Response To Type II Interferon Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Fatty Acid Oxidation Regulation Of Circadian Rhythm Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Lipid Transport Nuclear Steroid Receptor Activity Regulation Of Defense Response Negative Regulation Of RNA Metabolic Process Response To Nutrient Regulation Of Protein Transport Positive Regulation Of Cholesterol Efflux Negative Regulation Of Myoblast Differentiation Negative Regulation Of Receptor Signaling Pathway Via STAT Negative Regulation Of Cell Growth Sequence-specific DNA Binding Monocarboxylic Acid Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process	Negative Regulation Of Telomere Maintenance Regulation Of Base-excision Repair Negative Regulation Of DNA Metabolic Process Mitochondrial DNA Repair Nucleolus Enzyme Binding Positive Regulation Of Programmed Necrotic Cell Death Regulation Of Cellular Component Organization Double-strand Break Repair Negative Regulation Of Chromosome Organization Chromatin Binding Site Of Double-strand Break Mitochondrial DNA Metabolic Process Regulation Of Telomere Maintenance Regulation Of Catalytic Activity Protein Localization To Organelle Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Response To Ionizing Radiation Protein Localization To Site Of Double-strand Break Response To X-ray Negative Regulation Of DNA Replication NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity Regulation Of Programmed Necrotic Cell Death NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Site Of DNA Damage NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity Regulation Of Organelle Organization Negative Regulation Of Cellular Component Organization NAD+-protein-histidine ADP-ribosyltransferase Activity NAD+-protein-tyrosine ADP-ribosyltransferase Activity Positive Regulation Of Metalloendopeptidase Activity Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Regulation Of Cell Growth Base-excision Repair Oxidized DNA Binding FHA Domain Binding FMN Adenylyltransferase Activity FAD Biosynthetic Process FAD Diphosphatase Activity Cellular Response To Glucose Starvation Regulation Of Telomere Maintenance Via Telomere Lengthening Response To Gamma Radiation Regulation Of DNA Metabolic Process Positive Regulation Of Myofibroblast Differentiation NAD+-protein-serine ADP-ribosyltransferase Activity DNA Repair