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CEP350 and PPARA
Number of citations of the paper that reports this interaction (PMID
15615782
)
6
Data Source:
BioGRID
(pull down)
CEP350
PPARA
Gene Name
centrosomal protein 350kDa
peroxisome proliferator-activated receptor alpha
Image
Gene Ontology Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Centrosome
Spindle
Membrane
Nucleus
Nucleoplasm
Molecular Function
Protein Binding
Microtubule Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription
RNA Polymerase II Repressing Transcription Factor Binding
RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Steroid Hormone Receptor Activity
Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity
Protein Binding
Drug Binding
Zinc Ion Binding
Lipid Binding
Phosphatase Binding
Protein Domain Specific Binding
Ubiquitin Conjugating Enzyme Binding
Protein Complex Binding
Sequence-specific DNA Binding
NFAT Protein Binding
MDM2/MDM4 Family Protein Binding
Biological Process
Microtubule Anchoring
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Response To Hypoxia
Transcription Initiation From RNA Polymerase II Promoter
Lipid Metabolic Process
Fatty Acid Metabolic Process
Heart Development
Circadian Rhythm
Epidermis Development
Gene Expression
Negative Regulation Of Macrophage Derived Foam Cell Differentiation
Negative Regulation Of Receptor Biosynthetic Process
Negative Regulation Of Cholesterol Storage
Negative Regulation Of Sequestering Of Triglyceride
Fatty Acid Transport
Intracellular Receptor Signaling Pathway
Positive Regulation Of Fatty Acid Beta-oxidation
Negative Regulation Of Protein Binding
Negative Regulation Of Appetite
Response To Insulin
Circadian Regulation Of Gene Expression
Behavioral Response To Nicotine
Wound Healing
Lipoprotein Metabolic Process
Regulation Of Circadian Rhythm
Steroid Hormone Mediated Signaling Pathway
Cellular Lipid Metabolic Process
Small Molecule Metabolic Process
Positive Regulation Of Gluconeogenesis
Negative Regulation Of Blood Pressure
Negative Regulation Of Glycolytic Process
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Fatty Acid Oxidation
Enamel Mineralization
Regulation Of Glycolytic By Positive Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Cellular Ketone Metabolic Process By Positive Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Neuron Death
Negative Regulation Of Transcription Regulatory Region DNA Binding
Pathways
PPARA activates gene expression
Organelle biogenesis and maintenance
Fatty acid, triacylglycerol, and ketone body metabolism
Metabolism of lipids and lipoproteins
Nuclear Receptor transcription pathway
REV-ERBA represses gene expression
RORA activates circadian gene expression
Mitochondrial biogenesis
Regulation of cholesterol biosynthesis by SREBP (SREBF)
Generic Transcription Pathway
Transcriptional regulation of white adipocyte differentiation
YAP1- and WWTR1 (TAZ)-stimulated gene expression
Activation of gene expression by SREBF (SREBP)
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Transcriptional activation of mitochondrial biogenesis
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Orphan transporters
Drugs
Clofibrate
Fenofibrate
Gemfibrozil
Bezafibrate
Deoxy-Bigchap
2-METHYL-2-(4-{[({4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-5-YL}CARBONYL)AMINO]METHYL}PHENOXY)PROPANOIC ACID
3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid
ALEGLITAZAR
Diseases
GWAS
Anorexia nervosa (
23568457
)
Protein-Protein Interactions
6 interactors:
APTX
NR1H3
PLEKHA5
PPARA
PPARD
PPARG
44 interactors:
AIP
AKAP13
CDK3
CEP350
CHD9
DAP3
DUT
EP300
FABP1
FOXA3
GADD45A
GADD45B
GADD45G
HELZ2
HSP90AA1
MAPK1
MAPK3
MECR
MED1
MED24
NCOA1
NCOA2
NCOA3
NCOR1
NCOR2
NR1H3
NRBF2
NRIP1
POU1F1
PPARGC1A
PPARGC1B
PRKCA
PRKCD
PRMT1
PRMT8
RELA
RXRA
RXRG
SIRT1
SRC
STAC3
SUMO1
TNP1
UBE2I
Entrez ID
9857
5465
HPRD ID
09870
01369
Ensembl ID
ENSG00000135837
ENSG00000186951
Uniprot IDs
Q5VT06
F1D8S4
Q07869
PDB IDs
2COZ
1I7G
1K7L
1KKQ
2NPA
2P54
2REW
2ZNN
3ET1
3FEI
3G8I
3KDT
3KDU
3SP6
3VI8
4BCR
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Cholesterol Storage
Steroid Hormone Mediated Signaling Pathway
Negative Regulation Of Macrophage Derived Foam Cell Differentiation
Regulation Of Receptor Biosynthetic Process
Negative Regulation Of Lipid Storage
Hormone-mediated Signaling Pathway
Positive Regulation Of Fatty Acid Metabolic Process
Transcription Initiation From RNA Polymerase II Promoter
Cellular Response To Steroid Hormone Stimulus
Intracellular Receptor Signaling Pathway
DNA-templated Transcription, Initiation
Regulation Of Macrophage Derived Foam Cell Differentiation
Regulation Of Lipid Storage
Fatty Acid Transport
Negative Regulation Of Collagen Biosynthetic Process
Negative Regulation Of Receptor Biosynthetic Process
Negative Regulation Of Interferon-gamma-mediated Signaling Pathway
Regulation Of Fatty Acid Metabolic Process
Negative Regulation Of Multicellular Organismal Metabolic Process
Cellular Response To Organic Cyclic Compound
Regulation Of Lipid Transport
Negative Regulation Of Sequestering Of Triglyceride
Regulation Of Circadian Rhythm
Cellular Response To Lipid
Negative Regulation Of Inflammatory Response
Response To Steroid Hormone
Monocarboxylic Acid Transport
Positive Regulation Of Fatty Acid Oxidation
Cellular Response To Hormone Stimulus
Regulation Of Interferon-gamma-mediated Signaling Pathway
Regulation Of Response To Interferon-gamma
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Response To Vitamin A
Regulation Of Fatty Acid Oxidation
Response To Lipid
Transcription From RNA Polymerase II Promoter
Response To Organic Cyclic Compound
Regulation Of Inflammatory Response
Regulation Of Collagen Metabolic Process
Response To Hormone
Regulation Of Cholesterol Transport
Negative Regulation Of Innate Immune Response
Negative Regulation Of Cytokine-mediated Signaling Pathway
Regulation Of Lipid Metabolic Process
Cellular Lipid Metabolic Process
Lipid Transport
Carboxylic Acid Transport
Organic Acid Transport
Negative Regulation Of Response To Cytokine Stimulus
Fatty Acid Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Metabolic Process
Intracellular Receptor Signaling Pathway
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Regulation Of Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Positive Regulation Of Gene Expression
Regulation Of RNA Metabolic Process
Intracellular Steroid Hormone Receptor Signaling Pathway
Transcription, DNA-templated
Gene Expression
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Transcription From RNA Polymerase II Promoter
RNA Biosynthetic Process
Regulation Of Transcription, DNA-templated
Response To Hormone
DNA-templated Transcription, Initiation
Organelle Organization
Regulation Of Gene Expression
Cellular Response To Organic Substance
Chromatin Organization
Transcription Initiation From RNA Polymerase II Promoter
Cellular Macromolecule Biosynthetic Process
Cellular Metabolic Process
Chromatin Modification
Negative Regulation Of Transcription, DNA-templated
Macromolecule Biosynthetic Process
Regulation Of Signal Transduction
Negative Regulation Of Nucleic Acid-templated Transcription
Response To Organic Substance
Peptidyl-amino Acid Modification
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Androgen Receptor Signaling Pathway
Positive Regulation Of Protein Metabolic Process
Transcription From RNA Polymerase II Promoter
Cellular Response To Hormone Stimulus
Regulation Of Signaling
Signal Transduction
Response To Steroid Hormone
Negative Regulation Of Gene Expression
Positive Regulation Of Cellular Protein Metabolic Process
Cellular Response To Stimulus
Cell Communication
Nucleobase-containing Compound Metabolic Process
Tagcloud
?
abca1
alfalfa
aragonesa
breed
concentrate
contrary
dams
finishing
grazed
grazing
indoors
lambs
lengths
lpl
lt
pparg
rasa
scarb1
sf
slaughtering
srebp1
subcutaneous
supplemented
thoracis
tocopherol
tocopheryl
ve10d
ve20d
ve30d
Tagcloud (Difference)
?
abca1
alfalfa
aragonesa
breed
concentrate
contrary
dams
finishing
grazed
grazing
indoors
lambs
lengths
lpl
lt
pparg
rasa
scarb1
sf
slaughtering
srebp1
subcutaneous
supplemented
thoracis
tocopherol
tocopheryl
ve10d
ve20d
ve30d
Tagcloud (Intersection)
?