ARHGEF17 and OTX1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		ARHGEF17	OTX1
Name		Rho guanine nucleotide exchange factor 17	orthodenticle homeobox 1
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Chromatin Nucleus
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Actin Cytoskeleton Organization Regulation Of Small GTPase Mediated Signal Transduction	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Anterior/posterior Pattern Specification Metencephalon Development Forebrain Development Midbrain Development Inner Ear Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Diencephalon Morphogenesis
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle	None
GWAS		FEV1 ( 30804560 ) GIP levels in response to oral glucose tolerance test (120 minutes) ( 29093273 ) Lung function (FEV1/FVC) ( 30804560 ) Peak expiratory flow ( 30804560 ) Refractive error ( 32231278 )	Fruit consumption ( 32066663 ) Neurociticism ( 29500382 ) Regular attendance at a religious group ( 29970889 ) Risk-taking tendency (4-domain principal component model) ( 30643258 )
Novel Interactors		1 novel interactors: RAB14	None recorded
Interacting Genes		3 interacting genes: OTX1 RHOA USP7	148 interacting genes: ADAM12 ADAMTSL4 ALPP ANKRD10 ARHGEF17 ARID5A ATG9B C10orf55 CCN4 CERCAM CFAP68 CH25H CHIC2 CHRD CHRDL2 COL8A1 COMP CTAG2 CYSRT1 DPY30 EFEMP2 ETFDH FAM168B FAM72B FBLN2 FBLN5 FHL5 GEMIN8P4 GPRASP3 GPRIN2 GRN HIVEP1 HOXA1 INTS11 KCNK16 KLHL26 KPRP KRT31 KRT35 KRT37 KRT81 KRT85 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-4 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP13-1 KRTAP13-2 KRTAP13-3 KRTAP17-1 KRTAP19-2 KRTAP19-6 KRTAP19-7 KRTAP2-3 KRTAP2-4 KRTAP22-1 KRTAP26-1 KRTAP3-1 KRTAP3-2 KRTAP3-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP4-7 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP7-1 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LASP1 LCE1B LCE1C LCE1F LCE2A LCE2B LCE2C LCE2D LCE4A LGALS13 M1AP MDFI MGAT5B MIIP MTNR1B NBPF19 NDUFAF6 NECTIN3 NHLRC4 NOTCH2NLA OXER1 PCSK5 PLA2G10 PLEKHG4 PLSCR2 POU2AF1 PRICKLE4 PRR13 PRR22 RBPMS RGS17 RGS19 RGS20 RNF144B RTN4R SLC15A2 SMARCC1 SPMIP9 SPRY1 SPRY2 SPRY4 SPRYD7 TLE4 TNS2 TRIM42 TRIP6 TSPAN4 UBAP2 USP54 VWC2 VWC2L WWOX YPEL3 ZBTB42 ZNF330 ZNF34
Entrez ID		9828	5013
HPRD ID		10658	08964
Ensembl ID		ENSG00000110237	ENSG00000115507
Uniprot IDs		Q96PE2	P32242
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Beta Selection Aortic Valve Formation Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure G Protein Activity Positive Regulation Of Vascular Associated Smooth Muscle Contraction Organelle Assembly Endothelial Tube Lumen Extension Mitotic Cleavage Furrow Formation Skeletal Muscle Satellite Cell Migration Metencephalon Development Diencephalon Morphogenesis Vacuole Organization Symbiont-mediated Disruption Of Host Cell PML Body Nuclear Outer Membrane-endoplasmic Reticulum Membrane Network Bone Trabecula Morphogenesis Phagolysosome Assembly Apolipoprotein A-I-mediated Signaling Pathway Roundabout Signaling Pathway Positive Regulation Of Lipase Activity Cleavage Furrow Formation Regulation Of Systemic Arterial Blood Pressure By Endothelin Negative Regulation Of Cell Size Apical Junction Assembly GTPase Activity Ossification Involved In Bone Maturation Negative Regulation Of Cellular Respiration Negative Regulation Of Oxidative Phosphorylation Forebrain Radial Glial Cell Differentiation Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Regulation Of Establishment Of Protein Localization To Chromosome Monoubiquitinated Protein Deubiquitination Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Retrograde Transport, Endosome To Golgi Regulation Of Modification Of Postsynaptic Structure Motor Neuron Apoptotic Process Positive Regulation Of Podosome Assembly Regulation Of Podosome Assembly Regulation Of Motor Neuron Apoptotic Process Cellular Response To Chemokine Positive Regulation Of Systemic Arterial Blood Pressure Regulation Of Vascular Associated Smooth Muscle Contraction Hydrolase Activity Negative Regulation Of Motor Neuron Apoptotic Process Heart Valve Formation Negative Regulation Of Reactive Oxygen Species Biosynthetic Process GTP Binding Endothelial Tube Morphogenesis Establishment Of Epithelial Cell Apical/basal Polarity Radial Glial Cell Differentiation Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation	Intermediate Filament Keratin Filament Keratinization Epidermis Development Hair Cycle Protein Binding Structural Molecule Activity Cytosol Structural Constituent Of Skin Epidermis Negative Regulation Of Cellular Response To Growth Factor Stimulus