ARHGEF17

Description		Rho guanine nucleotide exchange factor 17
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Actin Cytoskeleton Organization Regulation Of Small GTPase Mediated Signal Transduction
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle
Drugs
Diseases
GWAS		FEV1 ( 30804560) GIP levels in response to oral glucose tolerance test (120 minutes) ( 29093273) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560) Refractive error ( 32231278)
Novel Interacting Genes		1 novel interacting genes: RAB14
Interacting Genes		3 interacting genes: OTX1 RHOA USP7
Entrez ID		9828
HPRD ID		10658
Ensembl ID		ENSG00000110237
Uniprot IDs		Q96PE2
PDB IDs
Enriched GO Terms of Interacting Partners?		Beta Selection Aortic Valve Formation Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure G Protein Activity Positive Regulation Of Vascular Associated Smooth Muscle Contraction Organelle Assembly Endothelial Tube Lumen Extension Mitotic Cleavage Furrow Formation Skeletal Muscle Satellite Cell Migration Metencephalon Development Diencephalon Morphogenesis Vacuole Organization Symbiont-mediated Disruption Of Host Cell PML Body Nuclear Outer Membrane-endoplasmic Reticulum Membrane Network Bone Trabecula Morphogenesis Phagolysosome Assembly Apolipoprotein A-I-mediated Signaling Pathway Roundabout Signaling Pathway Positive Regulation Of Lipase Activity Cleavage Furrow Formation Regulation Of Systemic Arterial Blood Pressure By Endothelin Negative Regulation Of Cell Size Apical Junction Assembly GTPase Activity Ossification Involved In Bone Maturation Negative Regulation Of Cellular Respiration Negative Regulation Of Oxidative Phosphorylation Forebrain Radial Glial Cell Differentiation Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Regulation Of Establishment Of Protein Localization To Chromosome Monoubiquitinated Protein Deubiquitination Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Retrograde Transport, Endosome To Golgi Regulation Of Modification Of Postsynaptic Structure Motor Neuron Apoptotic Process Positive Regulation Of Podosome Assembly Regulation Of Podosome Assembly Regulation Of Motor Neuron Apoptotic Process Cellular Response To Chemokine Positive Regulation Of Systemic Arterial Blood Pressure Regulation Of Vascular Associated Smooth Muscle Contraction Hydrolase Activity Negative Regulation Of Motor Neuron Apoptotic Process Heart Valve Formation Negative Regulation Of Reactive Oxygen Species Biosynthetic Process GTP Binding Endothelial Tube Morphogenesis Establishment Of Epithelial Cell Apical/basal Polarity Radial Glial Cell Differentiation Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation
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