ETF1 and GSPT1

Number of citations of the paper that reports this interaction (PMID 18256688)
76

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vivo)

		ETF1	GSPT1
Gene Name		eukaryotic translation termination factor 1	G1 to S phase transition 1
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol	Intracellular
	Molecular Function	RNA Binding Translation Release Factor Activity Protein Binding Translation Termination Factor Activity Translation Release Factor Activity, Codon Specific Ribosome Binding Poly(A) RNA Binding	Translation Release Factor Activity GTPase Activity Protein Binding GTP Binding Poly(A) RNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Termination Regulation Of Translational Termination Protein Methylation Gene Expression Cellular Protein Metabolic Process	G1/S Transition Of Mitotic Cell Cycle Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translational Termination Protein Methylation
Pathways		Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Nonsense-Mediated Decay (NMD) Translation Eukaryotic Translation Termination Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: GSPT1 GSPT2 KEAP1 LIG4 PPP2CA	10 interactors: ATXN1 BIRC2 BIRC3 CDKN2A ETF1 GSPT2 HINFP PABPC1 PIK3R1 XIAP
Entrez ID		2107	2935
HPRD ID		02616	00753
Ensembl ID		ENSG00000120705	ENSG00000103342
Uniprot IDs		B7Z7P8 P62495 Q96CG1	B2RCT6 P15170 Q7KZX8
PDB IDs		1DT9 2HST 2KTU 2KTV 2LGT 2LLX 3E1Y	3E1Y 3KUI
Enriched GO Terms of Interacting Partners?		Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Cellular Macromolecule Catabolic Process RNA Metabolic Process Cell Cycle Aromatic Compound Catabolic Process MRNA Metabolic Process Catabolic Process DNA Ligation Involved In DNA Recombination Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Translational Termination Cellular Nitrogen Compound Metabolic Process Cellular Protein Complex Disassembly Nitrogen Compound Metabolic Process Protein Complex Disassembly Proteasomal Ubiquitin-independent Protein Catabolic Process Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Lagging Strand Elongation Pro-B Cell Differentiation Establishment Of Integrated Proviral Latency Immunoglobulin V(D)J Recombination Mitotic Nuclear Envelope Reassembly Establishment Of Viral Latency Gene Expression T Cell Receptor V(D)J Recombination DNA Ligation Involved In DNA Repair Protein Heterotrimerization Cellular Macromolecule Biosynthetic Process Lymphoid Progenitor Cell Differentiation Nuclear Envelope Reassembly Macromolecule Biosynthetic Process Regulation Of Protein Catabolic Process Regulation Of Cell Differentiation DNA Ligation Nucleotide-excision Repair, DNA Gap Filling Cellular Response To Lithium Ion Negative Regulation Of Epithelial To Mesenchymal Transition In Utero Embryonic Development Single Strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of JAK-STAT Cascade Cellular Protein Metabolic Process Isotype Switching V(D)J Recombination DNA Strand Elongation Involved In DNA Replication Regulation Of Protein Autophosphorylation	Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Positive Regulation Of Cellular Metabolic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Protein Ubiquitination Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Negative Regulation Of Necroptotic Process Negative Regulation Of Necrotic Cell Death Regulation Of Endopeptidase Activity Regulation Of RIG-I Signaling Pathway Regulation Of Necroptotic Process Regulation Of Peptidase Activity Positive Regulation Of Protein Ubiquitination Apoptotic Process Posttranscriptional Regulation Of Gene Expression Nuclear-transcribed MRNA Catabolic Process Programmed Cell Death Regulation Of Necrotic Cell Death MRNA Catabolic Process Cell Death Death Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process RNA Catabolic Process Necroptotic Process Protein Ubiquitination RNA Metabolic Process Positive Regulation Of Protein Metabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Signal Transduction Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of Immune System Process Negative Regulation Of Cell-matrix Adhesion Gene Expression Regulation Of Proteolysis Regulation Of Innate Immune Response Regulation Of Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Programmed Necrotic Cell Death Cellular Macromolecule Biosynthetic Process Necrotic Cell Death Negative Regulation Of Endopeptidase Activity Regulation Of Apoptotic Process
Tagcloud ?		adequate axillary classification classifier classifiers differentially enough eny2 fbx033 flj339115 flj33915 heterogeneity indicative infiltrated malignancy multiplex nodes osbpl parts predicting prognostic rps7 sets solely subdivides subgroup subtype usp38 validate	abnormally blasts bmmncs chest clustered customized ddit3 dimerization ets etv1 helicase mad max microarray pathogenetic raeb raebt refractory ribs rnahp rtc semiquantitative seventeen tensin thbs1 thrombocytopenia thrombospondin transcriptome try
Tagcloud (Difference) ?		adequate axillary classification classifier classifiers differentially enough eny2 fbx033 flj339115 flj33915 heterogeneity indicative infiltrated malignancy multiplex nodes osbpl parts predicting prognostic rps7 sets solely subdivides subgroup subtype usp38 validate	abnormally blasts bmmncs chest clustered customized ddit3 dimerization ets etv1 helicase mad max microarray pathogenetic raeb raebt refractory ribs rnahp rtc semiquantitative seventeen tensin thbs1 thrombocytopenia thrombospondin transcriptome try
Tagcloud (Intersection) ?