ETF1 and GSPT1

Number of citations of the paper that reports this interaction (PubMedID 34349018)
55

Data Source:
BioGRID (affinity chromatography technology, cross-linking study)
HPRD (in vivo, two hybrid)

		ETF1	GSPT1
Description		eukaryotic translation termination factor 1	G1 to S phase transition 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Translation Release Factor Complex Cytosolic Ribosome	Cytoplasm Cytosol Translation Release Factor Complex Cytosolic Ribosome
	Molecular Function	RNA Binding Translation Release Factor Activity Peptidyl-tRNA Hydrolase Activity Protein Binding Translation Termination Factor Activity Translation Release Factor Activity, Codon Specific Ribosome Binding Sequence-specific MRNA Binding	Nucleotide Binding RNA Binding Translation Release Factor Activity GTPase Activity Protein Binding GTP Binding Hydrolase Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytoplasmic Translational Termination Translation Translational Termination Regulation Of Translational Termination Protein Methylation Ribosome Disassembly	G1/S Transition Of Mitotic Cell Cycle Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Termination Regulation Of Translational Termination Protein Methylation Ribosome Disassembly
Pathways		Eukaryotic Translation Termination Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Protein hydroxylation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Eukaryotic Translation Termination Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs			Guanosine-5'-Diphosphate
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28552196) California verbal learning test score ( 31596458) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) General risk tolerance (MTAG) ( 30643258) Schizophrenia ( 25056061 28991256 29483656 30285260)	Height ( 28552196) High light scatter reticulocyte percentage of red cells ( 32888494) Menopause (age at onset) ( 26414677) Red blood cell count ( 32888494) Testicular germ cell tumor ( 26503584)
Interacting Genes		8 interacting genes: CEBPA GSPT1 GSPT2 KEAP1 LIG4 OGT PPP2CA UBC	13 interacting genes: ATXN1 BIRC2 BIRC3 CDKN2A CEBPA CRBN ETF1 GSPT2 HINFP PABPC1 PIK3R1 USP15 XIAP
Entrez ID		2107	2935
HPRD ID		02616	00753
Ensembl ID		ENSG00000120705	ENSG00000103342
Uniprot IDs		B7Z7P8 P62495	B2RCT6 P15170 Q7KZX8
PDB IDs		1DT9 2HST 2KTU 2KTV 2LGT 2LLX 2MQ6 2MQ9 3E1Y 3J5Y 3JAG 3JAH 3JAI 4D5N 4D61 5A8L 5LZT 5LZU 5LZV 6D90 6IP8 6XA1 6ZME 8SCB	3E1Y 3J5Y 3KUI 4D61 5HXB 5LZT 6XK9
Enriched GO Terms of Interacting Partners?		Translation Release Factor Complex Translation Release Factor Activity Stem Cell Proliferation Translational Termination Cellular Response To Lithium Ion Macromolecule Catabolic Process Response To Lithium Ion Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Embryonic Placenta Development Macromolecule Metabolic Process In Utero Embryonic Development Positive Regulation Of Proteolysis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Granulocyte Differentiation Negative Regulation Of Macromolecule Biosynthetic Process Macrophage Differentiation Negative Regulation Of Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Biosynthetic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Macromolecule Biosynthetic Process Response To Fluid Shear Stress Granulocyte Macrophage Colony-stimulating Factor Receptor Binding Protein Modification Process Catabolic Process RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Establishment Of Integrated Proviral Latency Regulation Of Glycolytic Process RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Granzyme-mediated Apoptotic Signaling Pathway Chordate Embryonic Development Multicellular Organism Development Embryo Development Ending In Birth Or Egg Hatching Regulation Of Carbohydrate Catabolic Process Negative Regulation Of Macromolecule Metabolic Process Response To Vitamin B2 C/EBP Complex Establishment Of Viral Latency Regulation Of ATP Metabolic Process RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Cell Population Proliferation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Mononuclear Cell Differentiation Response To Metal Ion Regulation Of Purine Nucleotide Metabolic Process	Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of RIG-I Signaling Pathway RNA Metabolic Process Translation Release Factor Complex Positive Regulation Of Post-translational Protein Modification Macromolecule Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Release Factor Activity Regulation Of Protein Ubiquitination Regulation Of Macromolecule Metabolic Process Canonical NF-kappaB Signal Transduction DNA-templated Transcription Regulation Of Innate Immune Response Positive Regulation Of Protein Metabolic Process Regulation Of Defense Response Intracellular Signaling Cassette Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Post-translational Protein Modification Nucleic Acid Metabolic Process Regulation Of Metabolic Process Macromolecule Biosynthetic Process Translational Termination Regulation Of Primary Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Macromolecule Catabolic Process Positive Regulation Of Signal Transduction Nucleus Regulation Of Cell Cycle Positive Regulation Of Protein Ubiquitination Regulation Of Immune System Process Negative Regulation Of Biosynthetic Process Nuclear-transcribed MRNA Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Protein Polyubiquitination Negative Regulation Of Hemopoiesis Negative Regulation Of Necroptotic Process Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Programmed Necrotic Cell Death Cytosol MRNA Catabolic Process Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Poly(U) RNA Binding Positive Regulation Of Protein Modification Process Positive Regulation Of RNA Metabolic Process
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