AK4 and EPHA8

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		AK4	EPHA8
Gene Name		adenylate kinase 4	EPH receptor A8
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Early Endosome Membrane Neuron Projection
	Molecular Function	Adenylate Kinase Activity Nucleoside Diphosphate Kinase Activity ATP Binding GTP Binding Nucleoside Triphosphate Adenylate Kinase Activity	GPI-linked Ephrin Receptor Activity ATP Binding
	Biological Process	Liver Development Nucleoside Diphosphate Phosphorylation ADP Biosynthetic Process Brain Development Nucleoside Triphosphate Biosynthetic Process Response To Drug AMP Metabolic Process ATP Metabolic Process GTP Metabolic Process	Substrate-dependent Cell Migration Cell Adhesion Axon Guidance Neuron Remodeling Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Neuron Projection Development Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase Activity Protein Autophosphorylation Ephrin Receptor Signaling Pathway
Pathways			EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: APP CEP19 EPHA8 KEAP1	11 interactors: AK4 DARS2 EFNA1 EFNA4 EFNA5 FYN G3BP1 PIK3CG PSMC5 UBC ZNF746
Entrez ID		205	2046
HPRD ID		00048	01493
Ensembl ID		ENSG00000162433	ENSG00000070886
Uniprot IDs		P27144	P29322
PDB IDs		2AR7 2BBW 3NDP	1UCV 1X5L 3KUL
Enriched GO Terms of Interacting Partners?		Neuron Remodeling Neuron Maturation Cell Maturation Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Proteasomal Ubiquitin-independent Protein Catabolic Process Positive Regulation Of Proteolysis Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Axon Guidance Positive Regulation Of Cellular Metabolic Process Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Cellular Copper Ion Homeostasis Regulation Of Proteolysis Cellular Protein Modification Process Cell Morphogenesis Involved In Differentiation Copper Ion Homeostasis Suckling Behavior Positive Regulation Of Metabolic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Kinase Activity Neuron Projection Development Positive Regulation Of Phosphatidylinositol 3-kinase Activity MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Cell Projection Morphogenesis Cell Part Morphogenesis Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis RNA Polyadenylation Substrate-dependent Cell Migration Neuron Recognition Neuron Development Cellular Response To Interleukin-4 Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Epidermal Cell Differentiation Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Morphogenesis Regulation Of Cell Cycle G2/M Phase Transition Response To Interleukin-4 Cellular Protein Metabolic Process Regulation Of Phosphatidylinositol 3-kinase Activity	Ephrin Receptor Signaling Pathway Chemotaxis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Signal Transduction Axonogenesis Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Transferase Activity Axon Development Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of MAP Kinase Activity Regulation Of Signaling Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Cell Adhesion Locomotion Neuron Projection Morphogenesis Positive Regulation Of Signal Transduction Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of Gene Expression Regulation Of Protein Metabolic Process Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of MAP Kinase Activity Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Wnt Signaling Pathway DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Movement Of Cell Or Subcellular Component Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Signal Transduction Involved In DNA Damage Checkpoint Positive Regulation Of Intracellular Signal Transduction Signal Transduction Involved In Cell Cycle Checkpoint Neuron Projection Development Regulation Of Cell Death T Cell Proliferation Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Cell Projection Morphogenesis Cell Part Morphogenesis Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Phosphorylation Signal Transduction Mitochondrial Asparaginyl-tRNA Aminoacylation Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?		abolished adenocarcinoma adenylate advanced aggressive assist atf3 biomarkers invasion invasive limits lung mechanistically metastasis metastatic microarray overexpressing overexpression pivotal predicting promoted promotes promoting published recurrence simultaneous suppressed unfavorable upregulated
Tagcloud (Difference) ?		abolished adenocarcinoma adenylate advanced aggressive assist atf3 biomarkers invasion invasive limits lung mechanistically metastasis metastatic microarray overexpressing overexpression pivotal predicting promoted promotes promoting published recurrence simultaneous suppressed unfavorable upregulated
Tagcloud (Intersection) ?