AK4 and EPHA8

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		AK4	EPHA8
Name		adenylate kinase 4	EPH receptor A8
Structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix	Endosome Plasma Membrane Membrane Dendrite Early Endosome Membrane Cell Projection Neuron Projection
	Molecular Function	Nucleotide Binding AMP Kinase Activity Nucleoside Diphosphate Kinase Activity Protein Binding ATP Binding GTP Binding Kinase Activity Transferase Activity Phosphotransferase Activity, Phosphate Group As Acceptor Nucleobase-containing Compound Kinase Activity CMP Kinase Activity DCMP Kinase Activity Nucleoside Triphosphate Adenylate Kinase Activity DAMP Kinase Activity Nucleoside Monophosphate Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity GPI-linked Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity ATP Binding Kinase Activity Transferase Activity Growth Factor Binding
	Biological Process	Regulation Of Oxidative Phosphorylation Nucleobase-containing Compound Metabolic Process ADP Biosynthetic Process Nucleotide Metabolic Process Nucleoside Monophosphate Metabolic Process Nucleoside Triphosphate Biosynthetic Process Ribonucleoside Diphosphate Biosynthetic Process Nucleobase-containing Small Molecule Interconversion AMP Metabolic Process ATP Metabolic Process GTP Metabolic Process Nucleoside Monophosphate Phosphorylation Cellular Response To Hypoxia	Substrate-dependent Cell Migration Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Axon Guidance Neuron Remodeling Regulation Of Cell Adhesion Neuron Projection Development Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of MAPK Cascade Ephrin Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Follicle-stimulating Hormone Stimulus
Pathways		Interconversion of nucleotide di- and triphosphates	EPH-Ephrin signaling EPH-Ephrin signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells EPH-ephrin mediated repulsion of cells
Drugs		None	Fostamatinib
GWAS		Idiopathic osteonecrosis of the femoral head ( 28000841 )	Serum alkaline phosphatase levels ( 33547301 )
Interacting Genes		4 interacting genes: APP CEP19 EPHA8 KEAP1	12 interacting genes: AK4 DARS2 EFNA1 EFNA4 EFNA5 FYN G3BP1 LRRK1 PIK3CG PSMC5 PTPRD ZNF746
Entrez ID		205	2046
HPRD ID		00048	01493
Ensembl ID		ENSG00000162433	ENSG00000070886
Uniprot IDs		F8VS11 P27144	P29322
PDB IDs		2AR7 2BBW 3NDP	1UCV 1X5L 3KUL
GO Terms Enriched among Interactors		Neuron Remodeling Neuron Maturation Positive Regulation Of Proteolysis Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Plasma Membrane Bounded Cell Projection Organization Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Response To Calcium Ion Developmental Maturation Early Endosome Membrane Amylin Binding Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Protein Catabolic Process Endosome To Plasma Membrane Transport Vesicle Cell Maturation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Vesicle Targeting, Trans-Golgi To Periciliary Membrane Compartment Vesicle Targeting, To, From Or Within Golgi Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cell Projection Organization Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Cell Projection Axon Choice Point Recognition GPI-linked Ephrin Receptor Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Heparan Sulfate Binding Signaling Receptor Activator Activity Substrate-dependent Cell Migration	Ephrin Receptor Binding Ephrin Receptor Signaling Pathway ATP Binding Neuron Projection Guidance Axon Guidance Nucleotide Binding Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Synapse Organization Side Of Membrane Signaling Receptor Binding Regulation Of Postsynapse Organization Synaptic Membrane Adhesion Regulation Of Anatomical Structure Morphogenesis Regulation Of Neuron Projection Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Neuron Projection Development Positive Regulation Of Cellular Component Biogenesis Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Kinase Activity Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Regulation Of Dendritic Spine Development Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Component Organization Neurotrophin TRKC Receptor Binding Neurotrophin TRKB Receptor Binding Regulation Of Cell Morphogenesis Cellular Response To Glycine Response To Singlet Oxygen Aspartate-tRNA(Asn) Ligase Activity Mitochondrial Asparaginyl-tRNA Aminoacylation Regulation Of Protein Modification Process Positive Regulation Of Synapse Assembly Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Nucleoside Triphosphate Adenylate Kinase Activity Regulation Of Vasculature Development Regulation Of Angiogenesis Positive Regulation Of Phosphate Metabolic Process Regulation Of Peptidyl-tyrosine Phosphorylation Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction T Cell Proliferation Response To Glycine Nuclear Proteasome Complex DNA/RNA Helicase Activity Aspartyl-tRNA Aminoacylation