GUSB and CES1

Number of citations of the paper that reports this interaction (PMID 10562416)
2

Data Source:
HPRD (in vivo, in vitro)

		GUSB	CES1
Gene Name		glucuronidase, beta	carboxylesterase 1
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Gene Ontology Annotations	Cellular Component	Membrane Lysosomal Lumen Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome	Extracellular Space Endoplasmic Reticulum Lumen
	Molecular Function	Beta-glucuronidase Activity Receptor Binding Protein Domain Specific Binding	Methylumbelliferyl-acetate Deacetylase Activity Carboxylic Ester Hydrolase Activity
	Biological Process	Carbohydrate Metabolic Process Glycosaminoglycan Catabolic Process Pathogenesis Glycosaminoglycan Metabolic Process Hyaluronan Metabolic Process Hyaluronan Catabolic Process Small Molecule Metabolic Process	Metabolic Process Response To Toxic Substance Epithelial Cell Differentiation
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type Heparan sulfate/heparin (HS-GAG) metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Hyaluronan uptake and degradation Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Hyaluronan metabolism MPS IIID - Sanfilippo syndrome D Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome HS-GAG degradation
Drugs		Alpha-D-Mannose
Diseases
GWAS			Response to dabigatran etexilate treatment ( 23467860)
Protein-Protein Interactions		3 interactors: CES1 GIT2 PRKACA	2 interactors: BMPR2 GUSB
Entrez ID		2990	1066
HPRD ID		02018	00268
Ensembl ID		ENSG00000169919	ENSG00000198848
Uniprot IDs		P08236	P23141
PDB IDs		1BHG 3HN3	1MX1 1MX5 1MX9 1YA4 1YA8 1YAH 1YAJ 2DQY 2DQZ 2DR0 2H7C 2HRQ 2HRR 3K9B 4AB1
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Dense Core Granule Biogenesis Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Histone H3-T6 Phosphorylation Cellular Response To Erythropoietin Cellular Response To Interleukin-3 Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Parathyroid Hormone Stimulus Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Metal Ion Homeostasis Regulation Of Tight Junction Assembly Negative Regulation Of Glucose Import Positive Regulation Of Macrophage Differentiation Cell Communication By Electrical Coupling Involved In Cardiac Conduction Cellular Chemical Homeostasis Response To Parathyroid Hormone Calcium-mediated Signaling Using Intracellular Calcium Source Desmosome Organization Positive Regulation Of Protein Export From Nucleus Ion Homeostasis Cell Communication By Electrical Coupling Activation Of Protein Kinase A Activity Regulation Of Platelet Aggregation Negative Regulation Of Glucose Transport Sperm Capacitation Cellular Response To Epinephrine Stimulus Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Induction Of Positive Chemotaxis Positive Regulation Of Cardiac Muscle Hypertrophy Response To Epinephrine Cellular Copper Ion Homeostasis Cellular Response To Zinc Ion Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Lipopolysaccharide-mediated Signaling Pathway Cellular Homeostasis Triglyceride Catabolic Process Response To Cytokine Negative Regulation Of Adenylate Cyclase Activity Behavioral Response To Pain Copper Ion Homeostasis Negative Regulation Of Lyase Activity Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Response To Stress Regulation Of Rhodopsin Mediated Signaling Pathway	Regulation Of Lung Blood Pressure Negative Regulation Of Chondrocyte Proliferation Negative Regulation Of Vasoconstriction Positive Regulation Of Axon Extension Involved In Axon Guidance Lymphatic Endothelial Cell Differentiation Lymphangiogenesis Lymph Vessel Morphogenesis Hyaluronan Catabolic Process Regulation Of Axon Extension Involved In Axon Guidance Venous Blood Vessel Development Retina Vasculature Development In Camera-type Eye Lymph Vessel Development Negative Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of DNA Biosynthetic Process Activin Receptor Signaling Pathway Chondrocyte Development Positive Regulation Of BMP Signaling Pathway Hyaluronan Metabolic Process Positive Regulation Of Axon Extension Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Cartilage Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Blood Vessel Remodeling Regulation Of DNA Biosynthetic Process Negative Regulation Of Blood Pressure Lung Alveolus Development Regulation Of Pathway-restricted SMAD Protein Phosphorylation Proteoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Positive Regulation Of Endothelial Cell Migration Regulation Of Vasoconstriction Positive Regulation Of Endothelial Cell Proliferation Artery Development Regulation Of Axon Extension Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Axonogenesis BMP Signaling Pathway Endothelial Cell Differentiation Positive Regulation Of Epithelial Cell Migration Regulation Of BMP Signaling Pathway Endochondral Bone Morphogenesis Regulation Of Endothelial Cell Proliferation Chondrocyte Differentiation Mesoderm Formation Regulation Of Cartilage Development Endothelium Development Mesoderm Morphogenesis Regulation Of Systemic Arterial Blood Pressure
Tagcloud ?		actb assessments bestkeeper brca1 colon ercc1 esophageal gapdh gastrointestinal genorm normalized normfinder optimal personalized qrt ranking rectal reference represented rplpo rrm1 separately stmn1 taqman tfrc top2a tubb3 tyms vegfr2	4a a79v budding capping carboxyl carry ceg1 ceg1p ces1p ces4 ces4p defines delta evince gross grows multicopy permissive redundant restore saccharomyces segment suppress suppressors surmise temparature tif1 tif1p
Tagcloud (Difference) ?		actb assessments bestkeeper brca1 colon ercc1 esophageal gapdh gastrointestinal genorm normalized normfinder optimal personalized qrt ranking rectal reference represented rplpo rrm1 separately stmn1 taqman tfrc top2a tubb3 tyms vegfr2	4a a79v budding capping carboxyl carry ceg1 ceg1p ces1p ces4 ces4p defines delta evince gross grows multicopy permissive redundant restore saccharomyces segment suppress suppressors surmise temparature tif1 tif1p
Tagcloud (Intersection) ?