GUSB

Gene Name		glucuronidase, beta
Image
Gene Ontology Annotations	Cellular Component	Membrane Lysosomal Lumen Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome
	Molecular Function	Beta-glucuronidase Activity Receptor Binding Protein Domain Specific Binding
	Biological Process	Carbohydrate Metabolic Process Glycosaminoglycan Catabolic Process Pathogenesis Glycosaminoglycan Metabolic Process Hyaluronan Metabolic Process Hyaluronan Catabolic Process Small Molecule Metabolic Process
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type Heparan sulfate/heparin (HS-GAG) metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Hyaluronan uptake and degradation Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Hyaluronan metabolism MPS IIID - Sanfilippo syndrome D Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome HS-GAG degradation
Drugs		Alpha-D-Mannose
Diseases
GWAS
Protein-protein Interactions		3 interactors: CES1 GIT2 PRKACA
Entrez ID		2990
HPRD ID		02018
Ensembl ID		ENSG00000169919
Uniprot IDs		P08236
PDB IDs		1BHG 3HN3
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Dense Core Granule Biogenesis Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Histone H3-T6 Phosphorylation Cellular Response To Erythropoietin Cellular Response To Interleukin-3 Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Parathyroid Hormone Stimulus Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Metal Ion Homeostasis Regulation Of Tight Junction Assembly Negative Regulation Of Glucose Import Positive Regulation Of Macrophage Differentiation Cell Communication By Electrical Coupling Involved In Cardiac Conduction Cellular Chemical Homeostasis Response To Parathyroid Hormone Calcium-mediated Signaling Using Intracellular Calcium Source Desmosome Organization Positive Regulation Of Protein Export From Nucleus Ion Homeostasis Cell Communication By Electrical Coupling Activation Of Protein Kinase A Activity Regulation Of Platelet Aggregation Negative Regulation Of Glucose Transport Sperm Capacitation Cellular Response To Epinephrine Stimulus Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Induction Of Positive Chemotaxis Positive Regulation Of Cardiac Muscle Hypertrophy Response To Epinephrine Cellular Copper Ion Homeostasis Cellular Response To Zinc Ion Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Lipopolysaccharide-mediated Signaling Pathway Cellular Homeostasis Triglyceride Catabolic Process Response To Cytokine Negative Regulation Of Adenylate Cyclase Activity Behavioral Response To Pain Copper Ion Homeostasis Negative Regulation Of Lyase Activity Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Response To Stress Regulation Of Rhodopsin Mediated Signaling Pathway
Tagcloud ?		actb assessments bestkeeper brca1 colon ercc1 esophageal gapdh gastrointestinal genorm normalized normfinder optimal personalized qrt ranking rectal reference represented rplpo rrm1 separately stmn1 taqman tfrc top2a tubb3 tyms vegfr2