GUSB

Description		glucuronidase beta
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Membrane Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Beta-glucuronidase Activity Signaling Receptor Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Protein Domain Specific Binding Carbohydrate Binding
	Biological Process	Carbohydrate Metabolic Process Glycosaminoglycan Catabolic Process Heparan Sulfate Proteoglycan Catabolic Process Chondroitin Sulfate Proteoglycan Catabolic Process Hyaluronan Catabolic Process
Pathways		CS/DS degradation Hyaluronan degradation MPS VII - Sly syndrome (Hyaluronan metabolism) Neutrophil degranulation MPS VII - Sly syndrome (CS/DS degradation)
Drugs
Diseases		Mucopolysaccharidosis type VII (MPS7); Sly syndrome
GWAS		Liver enzyme levels (alkaline phosphatase) ( 33972514)
Interacting Genes		3 interacting genes: CES1 GIT2 PRKACA
Entrez ID		2990
HPRD ID		02018
Ensembl ID		ENSG00000169919
Uniprot IDs		P08236
PDB IDs		1BHG 3HN3
Enriched GO Terms of Interacting Partners?		Regulation Of Cholesterol Metabolic Process Positive Regulation Of Cholesterol Metabolic Process Positive Regulation Of Steroid Metabolic Process Regulation Of Steroid Biosynthetic Process Regulation Of Steroid Metabolic Process Positive Regulation Of Lipid Metabolic Process Cholesterol Ester Hydrolysis Involved In Cholesterol Transport Positive Regulation Of Small Molecule Metabolic Process Regulation Of Lipid Biosynthetic Process Methylumbelliferyl-acetate Deacetylase Activity Regulation Of Bile Acid Secretion Carboxylesterase Activity Sterol Ester Esterase Activity Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Protein Localization To Lipid Droplet Regulation Of Lipid Metabolic Process Regulation Of Small Molecule Metabolic Process CAMP-dependent Protein Kinase Activity Regulation Of Bile Acid Biosynthetic Process Regulation Of Bile Acid Metabolic Process Medium-chain Fatty Acid Metabolic Process Negative Regulation Of Cholesterol Storage CAMP-dependent Protein Kinase Complex Cellular Response To Parathyroid Hormone Stimulus Cellular Response To Glucagon Stimulus High-density Lipoprotein Particle Assembly Mitochondrial Protein Catabolic Process CAMP/PKA Signal Transduction Nucleotide-activated Protein Kinase Complex Channel Activator Activity Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Interleukin-2-mediated Signaling Pathway Cellular Response To Epinephrine Stimulus Cellular Response To Sterol Negative Regulation Of Lipid Storage Regulation Of Secretion Reverse Cholesterol Transport Cellular Response To Cholesterol Vascular Endothelial Cell Response To Fluid Shear Stress Negative Regulation Of Glycolytic Process Response To Laminar Fluid Shear Stress Sperm Capacitation Cellular Response To Laminar Fluid Shear Stress Plasma Lipoprotein Particle Assembly Regulation Of Bicellular Tight Junction Assembly Positive Regulation Of Cholesterol Biosynthetic Process Cell Communication By Electrical Coupling Renal Water Homeostasis Response To Parathyroid Hormone Positive Regulation Of Gluconeogenesis
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