PCLO and ERC2

Number of citations of the paper that reports this interaction (PMID 14734538)
39

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		PCLO	ERC2
Gene Name		piccolo presynaptic cytomatrix protein	ELKS/RAB6-interacting/CAST family member 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoskeleton Synaptic Vesicle Postsynaptic Density Membrane Cell Junction Synapse Presynaptic Cytoskeletal Matrix Assembled At Active Zones Extracellular Vesicular Exosome	Cytoplasm Cytoskeleton Cell Junction Growth Cone Presynaptic Membrane Presynaptic Active Zone
	Molecular Function	Transporter Activity Calcium Ion Binding Profilin Binding Calcium-dependent Phospholipid Binding	Protein Binding
	Biological Process	Cytoskeleton Organization Synaptic Vesicle Exocytosis Regulation Of Exocytosis CAMP-mediated Signaling Insulin Secretion
Pathways
Drugs
Diseases
GWAS		Major depressive disorder ( 21621269)	Bipolar disorder and schizophrenia ( 21057379) Hip geometry ( 17903296)
Protein-Protein Interactions		3 interactors: ERC2 GIT1 GIT2	8 interactors: BSN MYB PCLO PPFIA1 PPFIA2 PPFIA3 PPFIA4 RIMS1
Entrez ID		27445	26059
HPRD ID		16078	10810
Ensembl ID		ENSG00000186472	ENSG00000187672
Uniprot IDs		Q9Y6V0	O15083
PDB IDs		1UJD
Enriched GO Terms of Interacting Partners?		Regulation Of ARF GTPase Activity Regulation Of ARF Protein Signal Transduction Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Ras GTPase Activity Regulation Of Ras Protein Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Regulation Of GTPase Activity Behavioral Response To Pain Positive Regulation Of Hydrolase Activity Response To Pain Positive Regulation Of Catalytic Activity Regulation Of Cytokinesis Regulation Of Intracellular Signal Transduction Multicellular Organismal Response To Stress Ephrin Receptor Signaling Pathway Regulation Of Catalytic Activity Regulation Of Signal Transduction	Glutamate Secretion Neurotransmitter Secretion Regulation Of Neurotransmitter Levels Neurotransmitter Transport Acid Secretion Dicarboxylic Acid Transport Synaptic Transmission Amino Acid Transport Cell-cell Signaling Secretion By Cell Secretion Carboxylic Acid Transport Organic Acid Transport Organic Anion Transport Anion Transport Ion Transport Establishment Of Localization In Cell Cellular Localization Transport Synaptic Vesicle Exocytosis Regulation Of Neuronal Synaptic Plasticity Signaling Cell Communication Synaptic Vesicle Transport Regulation Of Synaptic Plasticity Cell-matrix Adhesion Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Establishment Of Vesicle Localization Vesicle Localization Cell-substrate Adhesion Calcium Ion-dependent Exocytosis Of Neurotransmitter Negative Regulation Of Stress Fiber Assembly Regulation Of Cellular Localization Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Histone H3-K9 Methylation Regulation Of Short-term Neuronal Synaptic Plasticity Regulation Of Synaptic Transmission Regulation Of Inhibitory Postsynaptic Membrane Potential Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane Establishment Of Organelle Localization Exocytosis Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Protein Localization To Plasma Membrane CAMP-mediated Signaling Regulation Of Histone H3-K4 Methylation Organelle Localization Cellular Response To Interleukin-6 Positive Regulation Of T-helper Cell Differentiation Cyclic-nucleotide-mediated Signaling Regulation Of Long-term Neuronal Synaptic Plasticity
Tagcloud ?		adcy axon betweenness bioinformatics circadian coefficients conservation ctnnb1 damaging databases deciphering ever exome gnal guidance hundreds illustrates integrating masked microenvironment mutated necessity otherwise percentages rps6ka3 speed tcga thousands workflow
Tagcloud (Difference) ?		adcy axon betweenness bioinformatics circadian coefficients conservation ctnnb1 damaging databases deciphering ever exome gnal guidance hundreds illustrates integrating masked microenvironment mutated necessity otherwise percentages rps6ka3 speed tcga thousands workflow
Tagcloud (Intersection) ?