PCLO and TMEM132D

Number of citations of the paper that reports this interaction (PubMedID 33726789)
50

Data Source:
BioGRID (two hybrid)

		PCLO	TMEM132D
Description		piccolo presynaptic cytomatrix protein	transmembrane protein 132D
Image			No pdb structure
GO Annotations	Cellular Component	Cytoskeleton Postsynaptic Density Axon Cell Projection Organelle Synapse Presynaptic Active Zone Cytoskeleton Of Presynaptic Active Zone Extracellular Exosome Glutamatergic Synapse GABA-ergic Synapse	Membrane
	Molecular Function	Calcium Ion Binding Profilin Binding Calcium-dependent Phospholipid Binding Zinc Ion Binding Metal Ion Binding Structural Constituent Of Presynaptic Active Zone	Protein Binding
	Biological Process	Cytoskeleton Organization Synaptic Vesicle Exocytosis Regulation Of Exocytosis Insulin Secretion Protein Localization To Synapse Maintenance Of Presynaptic Active Zone Structure Regulation Of Transport Regulation Of Biological Quality Synaptic Vesicle Clustering Presynaptic Actin Cytoskeleton Organization Presynapse Organization Presynaptic Active Zone Assembly
Pathways		Sensory processing of sound by inner hair cells of the cochlea
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Energy expenditure (24h) ( 28476931) Grapefruit juice consumption ( 31046077) HDL cholesterol levels in HIV infection ( 33109212) Major depressive disorder ( 20351715 21621269 28540843) Metabolite levels ( 23823483) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Refractive error ( 32231278) Rosacea symptom severity ( 29771307) Schizophrenia ( 33169155)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Anxiety disorder ( 25390645) Asthma ( 29273806) Blood protein levels ( 30072576) Body fat mass ( 28552196) Cognitive decline rate in late mild cognitive impairment ( 26252872) Heart rate ( 23534349) Initial pursuit acceleration ( 29064472) Male-pattern baldness ( 27182965) Mosquito bite size ( 28199695) Obesity-related traits ( 23251661) Positive urgency ( 30718321) Retinal venular tortuosity ( 31597446) Schizophrenia (inflammation and infection response interaction) ( 25781172) Sleep (1/2-day periodicity) ( 33075057) Triglyceride levels ( 34074324) Trunk fat mass ( 28552196) Type 2 diabetes (age of onset) ( 28060188)
Interacting Genes		6 interacting genes: ERC2 GIT1 GIT2 PCAT1 SNCA TMEM132D	70 interacting genes: ANKRD31 ANKRD36 ARL3 ATP1B1 ATP7A BNIP3L CADPS2 CCDC85A CD59 CMPK1 CNGB3 CNTN1 COMMD1 COX11 CPD EFEMP1 ENOPH1 FAM106A FMO2 GFM2 H3C1 HDAC2 HEBP2 HNRNPUL1 HOXA9 IDI2-AS1 IL13RA1 LNX1 MIR181A1HG MME NAMPT NCKAP1 NDUFS5 NPAS3 PAIP1 PCCA PCLO PGM1 PLSCR2 PNISR PRMT3 PRPF40A PTPN2 PTPRD RAB6A RCBTB2 RNF2 SAMD12 SDHB SEC22B SHLD2 SLC35E2A SRSF5 STK39 SVIL TCF12 TMED5 TMED7-TICAM2 TNFAIP8 TOB2 TPST1 TRAPPC11 TRAPPC8 TUBGCP5 UBA5 UMOD USP32P2 VPS13C ZBTB20 ZNF302
Entrez ID		27445	121256
HPRD ID		16078	13906
Ensembl ID		ENSG00000186472	ENSG00000151952
Uniprot IDs		Q9Y6V0	Q14C87
PDB IDs		1UJD
Enriched GO Terms of Interacting Partners?		Presynapse Regulation Of G Protein-coupled Receptor Signaling Pathway Synaptic Vesicle Priming Growth Cone Synaptic Vesicle Recycling Regulation Of ARF Protein Signal Transduction Maintenance Of Synapse Structure Regulation Of Vesicle Fusion Synapse Organization Synapse Cell Junction Maintenance Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Regulation Of Neurotransmitter Secretion Positive Regulation Of SNARE Complex Assembly Regulation Of Microtubule Polymerization Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Cell Junction Organization Cellular Component Maintenance Negative Regulation Of ARF Protein Signal Transduction Regulation Of Microtubule Polymerization Or Depolymerization GABA-ergic Synapse Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Regulation Of Vesicle-mediated Transport Regulation Of Calcium-dependent Activation Of Synaptic Vesicle Fusion Structural Constituent Of Postsynaptic Specialization Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Negative Regulation Of Dopamine Metabolic Process Regulation Of Microtubule Cytoskeleton Organization Regulation Of Serotonin Uptake Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Catecholamine Metabolic Process Regulation Of Exocytosis Locomotory Behavior Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Protein-containing Complex Assembly Intramembranous Ossification Response To Iron(II) Ion Calcium Ion Homeostasis Structural Constituent Of Presynaptic Active Zone Motor Learning Regulation Of Chaperone-mediated Autophagy Postsynapse Regulation Of Dopamine Uptake Involved In Synaptic Transmission	Golgi Vesicle Transport Protein Transport Into Plasma Membrane Raft Purine Nucleotide Metabolic Process Nucleotide Metabolic Process Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process ATP Metabolic Process Nucleoside Phosphate Metabolic Process Protein Transport Into Membrane Raft Positive Regulation Of Potassium Ion Import Across Plasma Membrane Purine Ribonucleotide Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Protein Localization To Plasma Membrane Raft Purine-containing Compound Metabolic Process Regulation Of Sodium Ion Transport Regulation Of Potassium Ion Import Positive Regulation Of Sodium Ion Transport
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