EIF4A3 and POLR2G

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		EIF4A3	POLR2G
Description		eukaryotic translation initiation factor 4A3	RNA polymerase II subunit G
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Cytoplasm Cytosol Membrane Nuclear Speck Dendrite Exon-exon Junction Complex Neuronal Cell Body U2-type Catalytic Step 1 Spliceosome Catalytic Step 2 Spliceosome Postsynapse Glutamatergic Synapse Ribonucleoprotein Complex	DNA-directed RNA Polymerase Complex P-body Nucleus Nucleoplasm RNA Polymerase II, Core Complex
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity MRNA Binding Helicase Activity Protein Binding ATP Binding Poly(A) Binding Hydrolase Activity ATP Hydrolysis Activity Selenocysteine Insertion Sequence Binding RNA Stem-loop Binding Ribonucleoprotein Complex Binding	Nucleic Acid Binding Single-stranded DNA Binding RNA Binding Single-stranded RNA Binding Protein Binding Translation Initiation Factor Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Splicing, Via Spliceosome RRNA Processing MRNA Processing MRNA Export From Nucleus Regulation Of Translation Associative Learning RNA Splicing Negative Regulation Of Gene Expression Negative Regulation Of Translation Exploration Behavior Positive Regulation Of Translation Embryonic Cranial Skeleton Morphogenesis MRNA Transport Cellular Response To Selenite Ion Negative Regulation Of Excitatory Postsynaptic Potential Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Negative Regulation Of Selenocysteine Incorporation Cellular Response To Brain-derived Neurotrophic Factor Stimulus Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay	Nuclear-transcribed MRNA Catabolic Process DNA-templated Transcription DNA-templated Transcription Initiation Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Positive Regulation Of Translational Initiation Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening
Pathways		ISG15 antiviral mechanism Transport of Mature mRNA derived from an Intron-Containing Transcript Deadenylation of mRNA Deadenylation of mRNA mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) M-decay: degradation of maternal mRNAs by maternally stored factors Z-decay: degradation of maternal mRNAs by zygotically expressed factors	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis MicroRNA (miRNA) biogenesis Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Myocardial infarction ( 26708285) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		38 interacting genes: ANKHD1 CARD9 CASC3 CCDC174 CDCA7L CEBPA CNKSR3 CTNND1 CWC22 DDIT4L DDX56 DISC1 DRG2 EHMT2 ERCC6 ESR1 HTR6 LNX1 MAGOH MEOX1 MEOX2 NIF3L1 NXF1 PAX4 PDCD4 PICK1 POLR2G PRMT5 PSMA1 RBM8A REL TRIM27 UPF1 UPF3B USP25 VRTN YWHAQ ZXDB	45 interacting genes: ATF7IP BCL2L15 C22orf15 CIB3 CNTNAP2 DDX54 DES DUSP29 EIF3D EIF4A3 EWSR1 FNDC4 FOSL2 GPKOW HOXC5 KIF5B LMO2 MAPK1 MCM3AP MCPH1 MYOD1 NOTCH2NLA NTRK2 OSGIN1 PARVG POLR1C POLR2A POLR2C POLR2D POLR2E POLR2F POLR2H PRKRA PSMB8 RPAP1 TAF15 TNNC1 TRAPPC2L TRIM14 TRIM68 TSEN15 UPRT VHL WHR1 ZNF410
Entrez ID		9775	5436
HPRD ID		06482	15995
Ensembl ID		ENSG00000141543	ENSG00000168002
Uniprot IDs		I3L3H2 P38919	P62487
PDB IDs		2HXY 2HYI 2J0Q 2J0S 2J0U 2XB2 3EX7 4C9B 5MQF 5XJC 5YZG 6ICZ 6QDV 6YVH 7A5P 7W59 7W5A 7W5B 7ZNJ 8C6J 8I0W 9FMD	2C35 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6DRD 6O9L 6XRE 7LBM 9EHZ 9EI1 9EI3 9EI4
Enriched GO Terms of Interacting Partners?		Exon-exon Junction Complex Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Macromolecule Metabolic Process Nucleus Negative Regulation Of Macromolecule Metabolic Process Nuclear-transcribed MRNA Catabolic Process Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Metabolic Process Regulation Of Gene Expression MRNA Export From Nucleus MRNA Transport MRNA Catabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process Negative Regulation Of Gene Expression RNA Export From Nucleus RNA Transport Negative Regulation Of Macromolecule Biosynthetic Process U2-type Catalytic Step 1 Spliceosome Negative Regulation Of Biosynthetic Process Regulation Of RNA Splicing Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay RNA Catabolic Process Nucleobase-containing Compound Transport Nuclear Export Exon-exon Junction Subcomplex Mago-y14 Regulation Of Protein Metabolic Process Nuclear Transport Nucleocytoplasmic Transport Positive Regulation Of MRNA Cis Splicing, Via Spliceosome Positive Regulation Of MRNA Splicing, Via Spliceosome RNA Metabolic Process Nuclear Speck Somite Specification Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Sequence-specific DNA Binding RNA Binding Chromatin Nucleoplasm Positive Regulation Of RNA Metabolic Process Nucleobase-containing Compound Catabolic Process Positive Regulation Of RNA Splicing Negative Regulation Of Type I Interferon Production Nucleic Acid Binding	DNA-directed RNA Polymerase Complex RNA Polymerase II, Core Complex DNA-directed RNA Polymerase Activity RNA Polymerase I Complex RNA Polymerase III Complex Nucleoplasm Transcription By RNA Polymerase II DNA-templated Transcription Nucleus Cerebral Cortex Development Nucleolus RNA Metabolic Process Nucleobase-containing Compound Biosynthetic Process Nucleic Acid Binding Cellular Response To Brain-derived Neurotrophic Factor Stimulus Outer Ear Morphogenesis Macromolecule Biosynthetic Process Transcription Coregulator Activity TRNA Transcription By RNA Polymerase III TRNA Transcription Contractile Muscle Fiber Macromolecule Metabolic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Striatum Development Transcription By RNA Polymerase I DNA Binding
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