EIF4A3 and CWC22

Number of citations of the paper that reports this interaction (PubMedID 29997244)
64

Data Source:
BioGRID (pull down, x-ray crystallography, fluorescent resonance energy transfer, affinity chromatography technology, proximity labelling technology)

		EIF4A3	CWC22
Description		eukaryotic translation initiation factor 4A3	CWC22 spliceosome associated protein
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Cytoplasm Cytosol Membrane Nuclear Speck Dendrite Exon-exon Junction Complex Neuronal Cell Body U2-type Catalytic Step 1 Spliceosome Catalytic Step 2 Spliceosome Postsynapse Glutamatergic Synapse Ribonucleoprotein Complex	Nucleus Nucleoplasm Spliceosomal Complex Cytosol Nuclear Speck U2-type Precatalytic Spliceosome U2-type Catalytic Step 1 Spliceosome U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity MRNA Binding Helicase Activity Protein Binding ATP Binding Poly(A) Binding Hydrolase Activity ATP Hydrolysis Activity Selenocysteine Insertion Sequence Binding RNA Stem-loop Binding Ribonucleoprotein Complex Binding	RNA Binding Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Splicing, Via Spliceosome RRNA Processing MRNA Processing MRNA Export From Nucleus Regulation Of Translation Associative Learning RNA Splicing Negative Regulation Of Gene Expression Negative Regulation Of Translation Exploration Behavior Positive Regulation Of Translation Embryonic Cranial Skeleton Morphogenesis MRNA Transport Cellular Response To Selenite Ion Negative Regulation Of Excitatory Postsynaptic Potential Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Negative Regulation Of Selenocysteine Incorporation Cellular Response To Brain-derived Neurotrophic Factor Stimulus Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome
Pathways		ISG15 antiviral mechanism Transport of Mature mRNA derived from an Intron-Containing Transcript Deadenylation of mRNA Deadenylation of mRNA mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) M-decay: degradation of maternal mRNAs by maternally stored factors Z-decay: degradation of maternal mRNAs by zygotically expressed factors	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Myocardial infarction ( 26708285) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)	Adult body size ( 32376654) Body mass index ( 28892062) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Schizophrenia ( 30285260)
Interacting Genes		38 interacting genes: ANKHD1 CARD9 CASC3 CCDC174 CDCA7L CEBPA CNKSR3 CTNND1 CWC22 DDIT4L DDX56 DISC1 DRG2 EHMT2 ERCC6 ESR1 HTR6 LNX1 MAGOH MEOX1 MEOX2 NIF3L1 NXF1 PAX4 PDCD4 PICK1 POLR2G PRMT5 PSMA1 RBM8A REL TRIM27 UPF1 UPF3B USP25 VRTN YWHAQ ZXDB	7 interacting genes: CFTR EIF4A3 EXOSC8 KLHL2 PDAP1 PTPN21 RNF10
Entrez ID		9775	57703
HPRD ID		06482	17220
Ensembl ID		ENSG00000141543	ENSG00000163510
Uniprot IDs		I3L3H2 P38919	Q9HCG8
PDB IDs		2HXY 2HYI 2J0Q 2J0S 2J0U 2XB2 3EX7 4C9B 5MQF 5XJC 5YZG 6ICZ 6QDV 6YVH 7A5P 7W59 7W5A 7W5B 7ZNJ 8C6J 8I0W 9FMD	4C9B 5MQF 5XJC 5YZG 5Z56 5Z57 5Z58 6FF7 6ICZ 6QDV 6YVH 6ZYM 7A5P 7DVQ 7QTT 7W59 7W5A 7W5B 8C6J 8CH6 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 9FMD
Enriched GO Terms of Interacting Partners?		Exon-exon Junction Complex Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Macromolecule Metabolic Process Nucleus Negative Regulation Of Macromolecule Metabolic Process Nuclear-transcribed MRNA Catabolic Process Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Metabolic Process Regulation Of Gene Expression MRNA Export From Nucleus MRNA Transport MRNA Catabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process Negative Regulation Of Gene Expression RNA Export From Nucleus RNA Transport Negative Regulation Of Macromolecule Biosynthetic Process U2-type Catalytic Step 1 Spliceosome Negative Regulation Of Biosynthetic Process Regulation Of RNA Splicing Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay RNA Catabolic Process Nucleobase-containing Compound Transport Nuclear Export Exon-exon Junction Subcomplex Mago-y14 Regulation Of Protein Metabolic Process Nuclear Transport Nucleocytoplasmic Transport Positive Regulation Of MRNA Cis Splicing, Via Spliceosome Positive Regulation Of MRNA Splicing, Via Spliceosome RNA Metabolic Process Nuclear Speck Somite Specification Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Sequence-specific DNA Binding RNA Binding Chromatin Nucleoplasm Positive Regulation Of RNA Metabolic Process Nucleobase-containing Compound Catabolic Process Positive Regulation Of RNA Splicing Negative Regulation Of Type I Interferon Production Nucleic Acid Binding	Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Macromolecule Catabolic Process Negative Regulation Of Selenocysteine Incorporation Cellular Response To Selenite Ion Positive Regulation Of Anion Channel Activity Positive Regulation Of Monoatomic Anion Transport Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Regulation Of Nervous System Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Positive Regulation Of Enamel Mineralization Selenocysteine Insertion Sequence Binding Regulation Of Translation At Postsynapse Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Negative Regulation Of Translational Elongation RNA Catabolic Process Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Exoribonuclease Complex Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRAMP-dependent TRNA Surveillance Pathway TRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation RRNA Processing Negative Regulation Of Schwann Cell Proliferation U4 SnRNA 3'-end Processing Amelogenesis Cellular Response To Brain-derived Neurotrophic Factor Stimulus Ribosome-associated Ubiquitin-dependent Protein Catabolic Process ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Regulation Of Translational Elongation Negative Regulation Of Excitatory Postsynaptic Potential Catabolic Process RRNA Metabolic Process TRNA Decay RRNA 3'-end Processing Nucleolar Exosome (RNase Complex) Nuclear MRNA Surveillance U2-type Catalytic Step 1 Spliceosome
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