EIF4A3 and PDCD4

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		EIF4A3	PDCD4
Gene Name		eukaryotic translation initiation factor 4A3	programmed cell death 4 (neoplastic transformation inhibitor)
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Speck Exon-exon Junction Complex Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	MRNA Binding ATP-dependent RNA Helicase Activity Protein Binding ATP Binding Poly(A) Binding Poly(A) RNA Binding	RNA Binding Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Splicing, Via Spliceosome RRNA Processing Gene Expression Negative Regulation Of Translation Cytokine-mediated Signaling Pathway Positive Regulation Of Translation Embryonic Cranial Skeleton Morphogenesis MRNA Transport	Apoptotic Process Cell Aging Negative Regulation Of JUN Kinase Activity Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated
Pathways		Nonsense-Mediated Decay (NMD) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Deadenylation of mRNA ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes Deadenylation-dependent mRNA decay
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: CASC3 CCDC174 CDCA7L MAGOH NXF1 PDCD4 RBM8A UPF1 YWHAQ	12 interactors: APOE BTRC CSNK2A1 EIF4A2 EIF4A3 EIF4G1 PSEN1 PSEN2 RPL5 RPLP1 RPS13 RPS6KA1
Entrez ID		9775	27250
HPRD ID		06482	10549
Ensembl ID		ENSG00000141543	ENSG00000150593
Uniprot IDs		P38919	B4DKX4 Q53EL6
PDB IDs		2HXY 2HYI 2J0Q 2J0S 2J0U 2XB2 3EX7	2GGF 2KZT 2RG8 2ZU6 3EIJ
Enriched GO Terms of Interacting Partners?		MRNA Transport RNA Transport RNA Localization MRNA Export From Nucleus RNA Export From Nucleus Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear Export Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Nucleocytoplasmic Transport Nuclear Transport Regulation Of Translation Aromatic Compound Catabolic Process Posttranscriptional Regulation Of Gene Expression MRNA Metabolic Process Cellular Localization Regulation Of Alternative MRNA Splicing, Via Spliceosome Cytoplasmic Transport Intracellular Transport Termination Of RNA Polymerase II Transcription Cellular Macromolecule Catabolic Process Regulation Of Gene Expression RNA Splicing Regulation Of Cellular Protein Metabolic Process Establishment Of Localization In Cell Gene Expression Regulation Of MRNA Splicing, Via Spliceosome DNA-templated Transcription, Termination MRNA Processing Regulation Of Protein Metabolic Process MRNA 3'-end Processing Regulation Of MRNA Processing Regulation Of RNA Splicing RNA 3'-end Processing RNA Processing Transport RNA Metabolic Process Catabolic Process Regulation Of Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Histone MRNA Catabolic Process Poly(A)+ MRNA Export From Nucleus Intracellular MRNA Localization Dosage Compensation By Inactivation Of X Chromosome Regulation Of Translational Termination Negative Regulation Of JUN Kinase Activity Dosage Compensation Histone MRNA Metabolic Process	Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Catabolic Process Regulation Of Cellular Protein Metabolic Process Aromatic Compound Catabolic Process Cellular Macromolecule Catabolic Process Negative Regulation Of Cellular Metabolic Process Translational Initiation Regulation Of Protein Metabolic Process MRNA Metabolic Process Viral Process Nuclear-transcribed MRNA Poly(A) Tail Shortening Protein Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Posttranscriptional Regulation Of Gene Expression Cell Surface Receptor Signaling Pathway Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Protein Catabolic Process Amyloid Precursor Protein Catabolic Process Regulation Of Translation MRNA 3'-end Processing Cellular Response To Organic Substance Viral Transcription Regulation Of Proteolysis Translation SRP-dependent Cotranslational Protein Targeting To Membrane Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum RNA 3'-end Processing Negative Regulation Of Catalytic Activity Protein Localization To Membrane Positive Regulation Of Cell Growth Beta-amyloid Metabolic Process Amyloid Precursor Protein Metabolic Process Protein Transport Regulation Of Protein Catabolic Process Protein Localization To Endoplasmic Reticulum Establishment Of Protein Localization Cellular Metabolic Process Membrane Protein Ectodomain Proteolysis Notch Receptor Processing Translational Termination Negative Regulation Of Apoptotic Process Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Catabolic Process
Tagcloud ?		attained chmp4c conceptually dba deg degs domestication dudeg dudegs ehh foxo3 fst homozygosity horse ideas integrating jeju kegg ontology pony rba reads seq thoroughbred thoroughbreds timeless wgs xp znf592	classes constituents cycling cyclins dexd dysregulation eif4a eif4a1 eif4b eif4e helicase helicases impede mcf7 microrna motors oncogenic otherwise pcdc4 polysome preferential quadruplexes ribosome structured translatome ubiquitous unwind unwinding utrs
Tagcloud (Difference) ?		attained chmp4c conceptually dba deg degs domestication dudeg dudegs ehh foxo3 fst homozygosity horse ideas integrating jeju kegg ontology pony rba reads seq thoroughbred thoroughbreds timeless wgs xp znf592	classes constituents cycling cyclins dexd dysregulation eif4a eif4a1 eif4b eif4e helicase helicases impede mcf7 microrna motors oncogenic otherwise pcdc4 polysome preferential quadruplexes ribosome structured translatome ubiquitous unwind unwinding utrs
Tagcloud (Intersection) ?