EIF4A3 and PAX4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		EIF4A3	PAX4
Description		eukaryotic translation initiation factor 4A3	paired box 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Cytoplasm Cytosol Membrane Nuclear Speck Dendrite Exon-exon Junction Complex Neuronal Cell Body U2-type Catalytic Step 1 Spliceosome Catalytic Step 2 Spliceosome Postsynapse Glutamatergic Synapse Ribonucleoprotein Complex	Chromatin Nucleus Nucleoplasm
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity MRNA Binding Helicase Activity Protein Binding ATP Binding Poly(A) Binding Hydrolase Activity ATP Hydrolysis Activity Selenocysteine Insertion Sequence Binding RNA Stem-loop Binding Ribonucleoprotein Complex Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Splicing, Via Spliceosome RRNA Processing MRNA Processing MRNA Export From Nucleus Regulation Of Translation Associative Learning RNA Splicing Negative Regulation Of Gene Expression Negative Regulation Of Translation Exploration Behavior Positive Regulation Of Translation Embryonic Cranial Skeleton Morphogenesis MRNA Transport Cellular Response To Selenite Ion Negative Regulation Of Excitatory Postsynaptic Potential Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Negative Regulation Of Selenocysteine Incorporation Cellular Response To Brain-derived Neurotrophic Factor Stimulus Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay	Type B Pancreatic Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Brain Development Sensory Organ Development Animal Organ Morphogenesis Cell Differentiation Forebrain Development Animal Organ Development Retina Development In Camera-type Eye
Pathways		ISG15 antiviral mechanism Transport of Mature mRNA derived from an Intron-Containing Transcript Deadenylation of mRNA Deadenylation of mRNA mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) M-decay: degradation of maternal mRNAs by maternally stored factors Z-decay: degradation of maternal mRNAs by zygotically expressed factors
Drugs
Diseases			Maturity onset diabetes of the young (MODY)
GWAS		High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Myocardial infarction ( 26708285) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)	Fruit consumption ( 32066663) Left-handedness ( 32989287) Metabolite levels ( 23823483) Nonsyndromic cleft palate ( 31609978) Type 2 diabetes ( 22158537 23532257 26818947 29632382 30718926 32499647 32794382) Type 2 diabetes (adjusted for BMI) ( 29632382)
Interacting Genes		38 interacting genes: ANKHD1 CARD9 CASC3 CCDC174 CDCA7L CEBPA CNKSR3 CTNND1 CWC22 DDIT4L DDX56 DISC1 DRG2 EHMT2 ERCC6 ESR1 HTR6 LNX1 MAGOH MEOX1 MEOX2 NIF3L1 NXF1 PAX4 PDCD4 PICK1 POLR2G PRMT5 PSMA1 RBM8A REL TRIM27 UPF1 UPF3B USP25 VRTN YWHAQ ZXDB	14 interacting genes: AURKA CABP5 EIF4A3 FBXO2 GMCL1 NAIF1 NECAB1 NFYC NME7 NRXN3 NTM NUTF2 PSMC1 UBL5
Entrez ID		9775	5078
HPRD ID		06482	01333
Ensembl ID		ENSG00000141543	ENSG00000106331
Uniprot IDs		I3L3H2 P38919	A0A1W2PPX4 J3KPG0
PDB IDs		2HXY 2HYI 2J0Q 2J0S 2J0U 2XB2 3EX7 4C9B 5MQF 5XJC 5YZG 6ICZ 6QDV 6YVH 7A5P 7W59 7W5A 7W5B 7ZNJ 8C6J 8I0W 9FMD
Enriched GO Terms of Interacting Partners?		Exon-exon Junction Complex Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Macromolecule Metabolic Process Nucleus Negative Regulation Of Macromolecule Metabolic Process Nuclear-transcribed MRNA Catabolic Process Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Metabolic Process Regulation Of Gene Expression MRNA Export From Nucleus MRNA Transport MRNA Catabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process Negative Regulation Of Gene Expression RNA Export From Nucleus RNA Transport Negative Regulation Of Macromolecule Biosynthetic Process U2-type Catalytic Step 1 Spliceosome Negative Regulation Of Biosynthetic Process Regulation Of RNA Splicing Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay RNA Catabolic Process Nucleobase-containing Compound Transport Nuclear Export Exon-exon Junction Subcomplex Mago-y14 Regulation Of Protein Metabolic Process Nuclear Transport Nucleocytoplasmic Transport Positive Regulation Of MRNA Cis Splicing, Via Spliceosome Positive Regulation Of MRNA Splicing, Via Spliceosome RNA Metabolic Process Nuclear Speck Somite Specification Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Sequence-specific DNA Binding RNA Binding Chromatin Nucleoplasm Positive Regulation Of RNA Metabolic Process Nucleobase-containing Compound Catabolic Process Positive Regulation Of RNA Splicing Negative Regulation Of Type I Interferon Production Nucleic Acid Binding
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