EIF4A3

Gene Name		eukaryotic translation initiation factor 4A3
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Speck Exon-exon Junction Complex Catalytic Step 2 Spliceosome
	Molecular Function	MRNA Binding ATP-dependent RNA Helicase Activity Protein Binding ATP Binding Poly(A) Binding Poly(A) RNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Splicing, Via Spliceosome RRNA Processing Gene Expression Negative Regulation Of Translation Cytokine-mediated Signaling Pathway Positive Regulation Of Translation Embryonic Cranial Skeleton Morphogenesis MRNA Transport
Pathways		Nonsense-Mediated Decay (NMD) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Deadenylation of mRNA ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes Deadenylation-dependent mRNA decay
Drugs
Diseases
GWAS
Protein-protein Interactions		9 interactors: CASC3 CCDC174 CDCA7L MAGOH NXF1 PDCD4 RBM8A UPF1 YWHAQ
Entrez ID		9775
HPRD ID		06482
Ensembl ID		ENSG00000141543
Uniprot IDs		P38919
PDB IDs		2HXY 2HYI 2J0Q 2J0S 2J0U 2XB2 3EX7
Enriched GO Terms of Interacting Partners?		MRNA Transport RNA Transport RNA Localization MRNA Export From Nucleus RNA Export From Nucleus Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear Export Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Nucleocytoplasmic Transport Nuclear Transport Regulation Of Translation Aromatic Compound Catabolic Process Posttranscriptional Regulation Of Gene Expression MRNA Metabolic Process Cellular Localization Regulation Of Alternative MRNA Splicing, Via Spliceosome Cytoplasmic Transport Intracellular Transport Termination Of RNA Polymerase II Transcription Cellular Macromolecule Catabolic Process Regulation Of Gene Expression RNA Splicing Regulation Of Cellular Protein Metabolic Process Establishment Of Localization In Cell Gene Expression Regulation Of MRNA Splicing, Via Spliceosome DNA-templated Transcription, Termination MRNA Processing Regulation Of Protein Metabolic Process MRNA 3'-end Processing Regulation Of MRNA Processing Regulation Of RNA Splicing RNA 3'-end Processing RNA Processing Transport RNA Metabolic Process Catabolic Process Regulation Of Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Histone MRNA Catabolic Process Poly(A)+ MRNA Export From Nucleus Intracellular MRNA Localization Dosage Compensation By Inactivation Of X Chromosome Regulation Of Translational Termination Negative Regulation Of JUN Kinase Activity Dosage Compensation Histone MRNA Metabolic Process
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