EIF4A3 and ANKHD1

Number of citations: 84 (PubMedID 34133714)
Data Source: BioGRID (two hybrid)

		EIF4A3	ANKHD1
Name		eukaryotic translation initiation factor 4A3	ankyrin repeat and KH domain containing 1
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Cytoplasm Cytosol Membrane Nuclear Speck Dendrite Exon-exon Junction Complex Neuronal Cell Body U2-type Catalytic Step 1 Spliceosome Catalytic Step 2 Spliceosome Postsynapse Glutamatergic Synapse Ribonucleoprotein Complex	Nucleus Cytoplasm
	Molecular Function	Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity MRNA Binding Helicase Activity Protein Binding ATP Binding Poly(A) Binding Hydrolase Activity ATP Hydrolysis Activity Selenocysteine Insertion Sequence Binding RNA Stem-loop Binding Ribonucleoprotein Complex Binding	Nucleic Acid Binding RNA Binding Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Splicing, Via Spliceosome RRNA Processing MRNA Processing MRNA Export From Nucleus Regulation Of Translation Associative Learning RNA Splicing Negative Regulation Of Gene Expression Negative Regulation Of Translation Exploration Behavior Positive Regulation Of Translation Embryonic Cranial Skeleton Morphogenesis MRNA Transport Cellular Response To Selenite Ion Negative Regulation Of Excitatory Postsynaptic Potential Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Negative Regulation Of Selenocysteine Incorporation Cellular Response To Brain-derived Neurotrophic Factor Stimulus Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay	Innate Immune Response
Pathways		ISG15 antiviral mechanism Transport of Mature mRNA derived from an Intron-Containing Transcript Deadenylation of mRNA Deadenylation of mRNA mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) M-decay: degradation of maternal mRNAs by maternally stored factors Z-decay: degradation of maternal mRNAs by zygotically expressed factors	None
GWAS		High light scatter reticulocyte count ( 27863252 32888494 ) High light scatter reticulocyte percentage of red cells ( 27863252 32888494 ) Immature fraction of reticulocytes ( 27863252 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Myocardial infarction ( 26708285 ) Reticulocyte count ( 27863252 32888494 ) Reticulocyte fraction of red cells ( 27863252 32888494 )	Bipolar disorder ( 31043756 ) Bipolar I disorder ( 31043756 ) Serum immune biomarker levels ( 32066700 )
Novel Interactors		1 novel interactors: CCR6	None recorded
Interacting Genes		38 interacting genes: ANKHD1 CARD9 CASC3 CCDC174 CDCA7L CEBPA CNKSR3 CTNND1 CWC22 DDIT4L DDX56 DISC1 DRG2 EHMT2 ERCC6 ESR1 HTR6 LNX1 MAGOH MEOX1 MEOX2 NIF3L1 NXF1 PAX4 PDCD4 PICK1 POLR2G PRMT5 PSMA1 RBM8A REL TRIM27 UPF1 UPF3B USP25 VRTN YWHAQ ZXDB	33 interacting genes: ATXN1 ATXN1L BAG4 BCAS2 DMRTB1 EIF3E EIF4A3 EIF4ENIF1 EXOSC8 FHL3 GOLGA2 KRTAP15-1 KRTAP19-5 LENG8 LUC7L2 NFKBIE NOD2 POLR2M PRR20A PRR20B PRR20C PRR20D PRR20E PRRC2B QKI RBFOX2 RBPMS RNF10 TXNL4A UBC YTHDF3 ZNF34 ZNF346
Entrez ID		9775	54882
HPRD ID		06482	16489
Ensembl ID		ENSG00000141543	ENSG00000131503
Uniprot IDs		I3L3H2 P38919	Q8IWZ3
PDB IDs		2HXY 2HYI 2J0Q 2J0S 2J0U 2XB2 3EX7 4C9B 5MQF 5XJC 5YZG 6ICZ 6QDV 6YVH 7A5P 7W59 7W5A 7W5B 7ZNJ 8C6J 8I0W 9FMD	Not available
GO Terms Enriched among Interactors		Exon-exon Junction Complex Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Macromolecule Metabolic Process Nucleus Negative Regulation Of Macromolecule Metabolic Process Nuclear-transcribed MRNA Catabolic Process Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Metabolic Process Regulation Of Gene Expression MRNA Export From Nucleus MRNA Transport MRNA Catabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process Negative Regulation Of Gene Expression RNA Export From Nucleus RNA Transport Negative Regulation Of Macromolecule Biosynthetic Process U2-type Catalytic Step 1 Spliceosome Negative Regulation Of Biosynthetic Process Regulation Of RNA Splicing Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay RNA Catabolic Process Nucleobase-containing Compound Transport Nuclear Export Exon-exon Junction Subcomplex Mago-y14 Regulation Of Protein Metabolic Process Nuclear Transport Nucleocytoplasmic Transport Positive Regulation Of MRNA Cis Splicing, Via Spliceosome Positive Regulation Of MRNA Splicing, Via Spliceosome RNA Metabolic Process Nuclear Speck Somite Specification Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Sequence-specific DNA Binding RNA Binding Chromatin Nucleoplasm Positive Regulation Of RNA Metabolic Process Nucleobase-containing Compound Catabolic Process Positive Regulation Of RNA Splicing Negative Regulation Of Type I Interferon Production Nucleic Acid Binding	RNA Binding MRNA Binding Regulation Of MRNA Metabolic Process POZ Domain Binding Membraneless Organelle Assembly RNA Metabolic Process MRNA Metabolic Process RNA Processing Negative Regulation Of Translation RNA Splicing Positive Regulation Of Myelination MRNA Splicing, Via Spliceosome Nucleus Regulation Of Translation Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Nuclear Export Regulation Of Gliogenesis Positive Regulation Of MRNA Catabolic Process Stress Granule Assembly RNA Splicing, Via Transesterification Reactions Regulation Of Nervous System Process Negative Regulation Of MRNA Metabolic Process Cytoplasmic Stress Granule MRNA Processing Internal N(7)-methylguanine-containing RNA Reader Activity Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Modification Negative Regulation Of Selenocysteine Incorporation Cellular Response To Selenite Ion P-body Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Detection Of Muramyl Dipeptide Muramyl Dipeptide Binding Maintenance Of ER Location