POLR2G and FNDC4

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		POLR2G	FNDC4
Gene Name		polymerase (RNA) II (DNA directed) polypeptide G	fibronectin type III domain containing 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Nucleus Nucleoplasm DNA-directed RNA Polymerase II, Core Complex Nucleolus	Endoplasmic Reticulum Plasma Membrane Integral Component Of Membrane
	Molecular Function	Single-stranded DNA Binding Single-stranded RNA Binding DNA-directed RNA Polymerase Activity Translation Initiation Factor Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic MRNA Splicing, Via Spliceosome DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Apoptotic Process RNA Splicing Gene Expression Viral Process PiRNA Metabolic Process Somatic Stem Cell Maintenance Positive Regulation Of Translational Initiation Positive Regulation Of Viral Transcription Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening
Pathways		RNA Polymerase II Promoter Escape mRNA Splicing Formation of HIV-1 elongation complex containing HIV-1 Tat PIWI-interacting RNA (piRNA) biogenesis Nucleotide Excision Repair RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Abortive elongation of HIV-1 transcript in the absence of Tat HIV Infection Regulatory RNA pathways Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery Formation of transcription-coupled NER (TC-NER) repair complex RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events Dual incision reaction in TC-NER Influenza Life Cycle HIV elongation arrest and recovery HIV Life Cycle HIV Transcription Initiation Influenza Viral RNA Transcription and Replication RNA Pol II CTD phosphorylation and interaction with CE Transcriptional regulation of pluripotent stem cells RNA Polymerase II HIV Promoter Escape HIV Transcription Elongation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation by small RNAs Processing of Capped Intron-Containing Pre-mRNA mRNA Capping mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway MicroRNA (miRNA) biogenesis Influenza Infection Pausing and recovery of Tat-mediated HIV elongation Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex RNA Polymerase II Transcription Initiation And Promoter Clearance Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Transcription-coupled NER (TC-NER) Viral Messenger RNA Synthesis Formation of the HIV-1 Early Elongation Complex RNA Polymerase II Transcription Initiation Transcription of the HIV genome RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS			Calcium levels ( 20705733) Chronic kidney disease ( 20383146) Hypertriglyceridemia ( 23505323) Menopause (age at onset) ( 22267201) Serum albumin level ( 23022100) Serum total protein level ( 23022100)
Protein-Protein Interactions		21 interactors: ATF7IP DDX54 EWSR1 FNDC4 MCM3AP MYOD1 NOTCH2NL NTRK2 POLR2A POLR2C POLR2D POLR2E POLR2F POLR2H POLR2K POLR2L PRKRA STK19 TAF15 TNNC1 VHL	1 interactors: POLR2G
Entrez ID		5436	64838
HPRD ID		15995	09965
Ensembl ID		ENSG00000168002	ENSG00000115226
Uniprot IDs		P62487	Q9H6D8
PDB IDs		2C35
Enriched GO Terms of Interacting Partners?		7-methylguanosine MRNA Capping Transcription Elongation From RNA Polymerase II Promoter PiRNA Metabolic Process 7-methylguanosine RNA Capping Transcription-coupled Nucleotide-excision Repair DNA-templated Transcription, Elongation Positive Regulation Of Viral Transcription Somatic Stem Cell Maintenance Regulation Of Viral Transcription Positive Regulation Of Viral Process Nucleotide-excision Repair Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Stem Cell Maintenance Regulation Of Viral Process Termination Of RNA Polymerase III Transcription Transcription Elongation From RNA Polymerase III Promoter Viral Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Processing Termination Of RNA Polymerase I Transcription Stem Cell Development Positive Regulation Of Gene Expression Transcription Elongation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Positive Regulation Of Cellular Biosynthetic Process Transcription From RNA Polymerase I Promoter Stem Cell Differentiation RNA Splicing Regulation Of Gene Expression, Epigenetic Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase III Promoter Transcription From RNA Polymerase II Promoter MRNA Processing NcRNA Metabolic Process Transcription, DNA-templated DNA-templated Transcription, Termination DNA Metabolic Process RNA Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Type I Interferon Production MRNA Metabolic Process Cellular Response To Stress Regulation Of Cell Differentiation Positive Regulation Of Cellular Metabolic Process RNA Metabolic Process DNA Repair Regulation Of Gene Expression Regulation Of Type I Interferon Production	Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Translational Initiation Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of MRNA 3'-end Processing Positive Regulation Of MRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic 7-methylguanosine MRNA Capping PiRNA Metabolic Process 7-methylguanosine RNA Capping Transcription-coupled Nucleotide-excision Repair Positive Regulation Of Viral Transcription Transcription Elongation From RNA Polymerase II Promoter Somatic Stem Cell Maintenance Regulation Of Viral Transcription Positive Regulation Of Viral Process Regulation Of Translational Initiation Positive Regulation Of Translation DNA-templated Transcription, Elongation Regulation Of MRNA Processing Nucleotide-excision Repair Nuclear-transcribed MRNA Catabolic Process Stem Cell Maintenance Regulation Of Viral Process MRNA Catabolic Process Transcription Initiation From RNA Polymerase II Promoter RNA Catabolic Process DNA-templated Transcription, Initiation MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Stem Cell Development Regulation Of Translation Stem Cell Differentiation RNA Splicing MRNA Processing Aromatic Compound Catabolic Process Posttranscriptional Regulation Of Gene Expression NcRNA Metabolic Process
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