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EIF4A3 and CCDC174
Number of citations of the paper that reports this interaction (PubMedID
35271311
)
106
Data Source:
BioGRID
(two hybrid, two hybrid, proximity labelling technology, affinity chromatography technology)
HPRD
(two hybrid)
EIF4A3
CCDC174
Description
eukaryotic translation initiation factor 4A3
coiled-coil domain containing 174
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Spliceosomal Complex
Nucleolus
Cytoplasm
Cytosol
Membrane
Nuclear Speck
Dendrite
Exon-exon Junction Complex
Neuronal Cell Body
U2-type Catalytic Step 1 Spliceosome
Catalytic Step 2 Spliceosome
Postsynapse
Glutamatergic Synapse
Ribonucleoprotein Complex
Nucleus
Nucleoplasm
Molecular Function
Nucleotide Binding
Nucleic Acid Binding
RNA Binding
RNA Helicase Activity
MRNA Binding
Helicase Activity
Protein Binding
ATP Binding
Poly(A) Binding
Hydrolase Activity
ATP Hydrolysis Activity
Selenocysteine Insertion Sequence Binding
RNA Stem-loop Binding
Ribonucleoprotein Complex Binding
Protein Binding
Biological Process
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
MRNA Splicing, Via Spliceosome
RRNA Processing
MRNA Processing
MRNA Export From Nucleus
Regulation Of Translation
Associative Learning
RNA Splicing
Negative Regulation Of Gene Expression
Negative Regulation Of Translation
Exploration Behavior
Positive Regulation Of Translation
Embryonic Cranial Skeleton Morphogenesis
MRNA Transport
Cellular Response To Selenite Ion
Negative Regulation Of Excitatory Postsynaptic Potential
Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission
Negative Regulation Of Selenocysteine Incorporation
Cellular Response To Brain-derived Neurotrophic Factor Stimulus
Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Pathways
ISG15 antiviral mechanism
Transport of Mature mRNA derived from an Intron-Containing Transcript
Deadenylation of mRNA
Deadenylation of mRNA
mRNA Splicing - Major Pathway
mRNA 3'-end processing
RNA Polymerase II Transcription Termination
Regulation of expression of SLITs and ROBOs
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
M-decay: degradation of maternal mRNAs by maternally stored factors
Z-decay: degradation of maternal mRNAs by zygotically expressed factors
Drugs
Diseases
GWAS
High light scatter reticulocyte count (
27863252
32888494
)
High light scatter reticulocyte percentage of red cells (
27863252
32888494
)
Immature fraction of reticulocytes (
27863252
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Myocardial infarction (
26708285
)
Reticulocyte count (
27863252
32888494
)
Reticulocyte fraction of red cells (
27863252
32888494
)
Sjögren's syndrome (
28076899
)
Interacting Genes
38 interacting genes:
ANKHD1
CARD9
CASC3
CCDC174
CDCA7L
CEBPA
CNKSR3
CTNND1
CWC22
DDIT4L
DDX56
DISC1
DRG2
EHMT2
ERCC6
ESR1
HTR6
LNX1
MAGOH
MEOX1
MEOX2
NIF3L1
NXF1
PAX4
PDCD4
PICK1
POLR2G
PRMT5
PSMA1
RBM8A
REL
TRIM27
UPF1
UPF3B
USP25
VRTN
YWHAQ
ZXDB
4 interacting genes:
ALOX5
EIF4A3
GSK3A
NAA10
Entrez ID
9775
51244
HPRD ID
06482
12820
Ensembl ID
ENSG00000141543
ENSG00000154781
Uniprot IDs
I3L3H2
P38919
A0A0B4J1R8
Q6PII3
PDB IDs
2HXY
2HYI
2J0Q
2J0S
2J0U
2XB2
3EX7
4C9B
5MQF
5XJC
5YZG
6ICZ
6QDV
6YVH
7A5P
7W59
7W5A
7W5B
7ZNJ
8C6J
8I0W
9FMD
Enriched GO Terms of Interacting Partners
?
Exon-exon Junction Complex
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Primary Metabolic Process
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Regulation Of Macromolecule Metabolic Process
Nucleus
Negative Regulation Of Macromolecule Metabolic Process
Nuclear-transcribed MRNA Catabolic Process
Regulation Of MRNA Splicing, Via Spliceosome
Negative Regulation Of Metabolic Process
Regulation Of Gene Expression
MRNA Export From Nucleus
MRNA Transport
MRNA Catabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Metabolic Process
Regulation Of MRNA Processing
Regulation Of MRNA Metabolic Process
Negative Regulation Of Gene Expression
RNA Export From Nucleus
RNA Transport
Negative Regulation Of Macromolecule Biosynthetic Process
U2-type Catalytic Step 1 Spliceosome
Negative Regulation Of Biosynthetic Process
Regulation Of RNA Splicing
Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
RNA Catabolic Process
Nucleobase-containing Compound Transport
Nuclear Export
Exon-exon Junction Subcomplex Mago-y14
Regulation Of Protein Metabolic Process
Nuclear Transport
Nucleocytoplasmic Transport
Positive Regulation Of MRNA Cis Splicing, Via Spliceosome
Positive Regulation Of MRNA Splicing, Via Spliceosome
RNA Metabolic Process
Nuclear Speck
Somite Specification
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Sequence-specific DNA Binding
RNA Binding
Chromatin
Nucleoplasm
Positive Regulation Of RNA Metabolic Process
Nucleobase-containing Compound Catabolic Process
Positive Regulation Of RNA Splicing
Negative Regulation Of Type I Interferon Production
Nucleic Acid Binding
Leukotriene A4 Metabolic Process
Leukotriene Production Involved In Inflammatory Response
Leukotriene A4 Biosynthetic Process
Arachidonate 5-lipoxygenase Activity
Arachidonate 8(S)-lipoxygenase Activity
Negative Regulation Of UDP-glucose Catabolic Process
Negative Regulation Of Type B Pancreatic Cell Development
Negative Regulation Of Glycogen (starch) Synthase Activity
Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway
Protein-N-terminal-alanine Acetyltransferase Activity
Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric
Protein-N-terminal-glutamate Acetyltransferase Activity
Negative Regulation Of Selenocysteine Incorporation
Cellular Response To Selenite Ion
Lipoxin Biosynthetic Process
Arachidonate 12(S)-lipoxygenase Activity
Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell
Protein N-terminal-serine Acetyltransferase Activity
Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission
Arachidonate Metabolite Production Involved In Inflammatory Response
Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell
Epoxide Metabolic Process
Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen
Postsynapse
Beta-arrestin-dependent Dopamine Receptor Signaling Pathway
Regulation Of Glycogen (starch) Synthase Activity
Regulation Of Centromeric Sister Chromatid Cohesion
Negative Regulation Of Sister Chromatid Cohesion
NatA Complex
Selenocysteine Insertion Sequence Binding
Negative Regulation Of Translational Elongation
Regulation Of Translation At Postsynapse
Autosome Genomic Imprinting
Positive Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Protein-N-terminal Amino-acid Acetyltransferase Activity
Negative Regulation Of Vascular Wound Healing
Cellular Response To Interleukin-3
Leukocyte Chemotaxis Involved In Inflammatory Response
Proximal Dendrite
Regulation Of Type B Pancreatic Cell Development
Negative Regulation Of Glycogen Biosynthetic Process
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Cellular Response To Brain-derived Neurotrophic Factor Stimulus
Lipoxygenase Pathway
Nuclear Envelope Lumen
Cardiac Left Ventricle Morphogenesis
Neuronal Cell Body
Internal Protein Amino Acid Acetylation
Regulation Of Translational Elongation
Negative Regulation Of Excitatory Postsynaptic Potential
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