POLR2G and POLR1C

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		POLR2G	POLR1C
Description		RNA polymerase II subunit G	RNA polymerase I and III subunit C
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GO Annotations	Cellular Component	DNA-directed RNA Polymerase Complex P-body Nucleus Nucleoplasm RNA Polymerase II, Core Complex	DNA-directed RNA Polymerase Complex Fibrillar Center Nucleus Nucleoplasm RNA Polymerase III Complex Nucleolus RNA Polymerase I Complex Cytoplasm Cytosol
	Molecular Function	Nucleic Acid Binding Single-stranded DNA Binding RNA Binding Single-stranded RNA Binding Protein Binding Translation Initiation Factor Binding	DNA Binding DNA-directed RNA Polymerase Activity Protein Binding Protein Dimerization Activity
	Biological Process	Nuclear-transcribed MRNA Catabolic Process DNA-templated Transcription DNA-templated Transcription Initiation Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Positive Regulation Of Translational Initiation Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening	DNA-templated Transcription Transcription By RNA Polymerase I
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis MicroRNA (miRNA) biogenesis Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression Inhibition of DNA recombination at telomere	Cytosolic sensors of pathogen-associated DNA NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase III Chain Elongation RNA Polymerase I Transcription Termination RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter
Drugs
Diseases			Treacher Collins syndrome
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	GLP-1 levels in response to oral glucose tolerance test (fasting) ( 29093273) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		45 interacting genes: ATF7IP BCL2L15 C22orf15 CIB3 CNTNAP2 DDX54 DES DUSP29 EIF3D EIF4A3 EWSR1 FNDC4 FOSL2 GPKOW HOXC5 KIF5B LMO2 MAPK1 MCM3AP MCPH1 MYOD1 NOTCH2NLA NTRK2 OSGIN1 PARVG POLR1C POLR2A POLR2C POLR2D POLR2E POLR2F POLR2H PRKRA PSMB8 RPAP1 TAF15 TNNC1 TRAPPC2L TRIM14 TRIM68 TSEN15 UPRT VHL WHR1 ZNF410	118 interacting genes: ADAMTSL4 ARHGEF5 ATRIP AVPI1 BIN3 BIRC7 BLZF1 C1orf105 C21orf58 CBX8 CBY2 CCDC33 CCNK CCT3 CGGBP1 CLU CORO1A CORO1B CRACR2A DRC4 EFHC2 EP400 FH FMR1 FOXR2 GMPPB GOLGA6A GOLGA6L9 GPRASP3 GRPEL1 GSTO2 HDX HNRNPH1 HOXB9 HOXD12 IHO1 IKZF3 INCA1 KCTD1 KCTD13 KLF15 KRT19 KRT75 KRT76 KRTAP12-2 KRTAP3-1 LNX2 LRIF1 LZTS1 LZTS2 MBIP MEI4 MEOX2 MKRN3 MORN3 MRPS23 MYD88 MYO5B NDUFB10 NEDD4 NFKBIB NIF3L1 NME1 NME4 PIH1D2 POLDIP3 POLR1D POLR1E POLR1G POLR2G POLR2J3 PPP2R3C PSMA1 RBM48 RIMBP3 RIMBP3C RSPH14 RUSC1 SAXO1 SMN1 SMN2 SORBS3 SPATC1L SPMIP10 SPMIP2 SPRY1 STMN3 TASOR2 TAX1BP1 TCF4 TFIP11 TIAM1 TLE5 TMEM121 TNFAIP1 TNNI1 TRAIP TRIM14 TRIM27 TRIOBP TSC22D4 UNKL USP54 VIM WASHC1 WRN XPA YPEL3 ZBED1 ZBTB42 ZC2HC1C ZFP57 ZIM2 ZNF547 ZNF554 ZNF655 ZNF688 ZNF835
Entrez ID		5436	9533
HPRD ID		15995	09661
Ensembl ID		ENSG00000168002	ENSG00000171453
Uniprot IDs		P62487	A0A2R8YEZ4 O15160
PDB IDs		2C35 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6DRD 6O9L 6XRE 7LBM 9EHZ 9EI1 9EI3 9EI4	7A6H 7AE1 7AE3 7AEA 7AST 7D58 7D59 7DN3 7DU2 7FJI 7FJJ 7OB9 7OBA 7OBB 7VBA 7VBB 7VBC 8A43 8ITY 8IUE 8IUH 9FSO 9FSP 9FSQ 9FSR 9FSS
Enriched GO Terms of Interacting Partners?		DNA-directed RNA Polymerase Complex RNA Polymerase II, Core Complex DNA-directed RNA Polymerase Activity RNA Polymerase I Complex RNA Polymerase III Complex Nucleoplasm Transcription By RNA Polymerase II DNA-templated Transcription Nucleus Cerebral Cortex Development Nucleolus RNA Metabolic Process Nucleobase-containing Compound Biosynthetic Process Nucleic Acid Binding Cellular Response To Brain-derived Neurotrophic Factor Stimulus Outer Ear Morphogenesis Macromolecule Biosynthetic Process Transcription Coregulator Activity TRNA Transcription By RNA Polymerase III TRNA Transcription Contractile Muscle Fiber Macromolecule Metabolic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Striatum Development Transcription By RNA Polymerase I DNA Binding	Protein Binding Nucleus Identical Protein Binding Supramolecular Fiber Organization DNA-directed RNA Polymerase Complex Regulation Of Nucleobase-containing Compound Metabolic Process SMN Complex Actin Filament Organization RNA Polymerase I Complex Regulation Of Actin Nucleation Regulation Of Primary Metabolic Process
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