POLR2G and HOXC5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		POLR2G	HOXC5
Description		RNA polymerase II subunit G	homeobox C5
Image			No pdb structure
GO Annotations	Cellular Component	DNA-directed RNA Polymerase Complex P-body Nucleus Nucleoplasm RNA Polymerase II, Core Complex	Chromatin Nucleus Nucleoplasm Cell Junction
	Molecular Function	Nucleic Acid Binding Single-stranded DNA Binding RNA Binding Single-stranded RNA Binding Protein Binding Translation Initiation Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process DNA-templated Transcription DNA-templated Transcription Initiation Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Positive Regulation Of Translational Initiation Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Anterior/posterior Pattern Specification Embryonic Skeletal System Development
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis MicroRNA (miRNA) biogenesis Transcriptional regulation by small RNAs PIWI-interacting RNA (piRNA) biogenesis Activation of anterior HOX genes in hindbrain development during early embryogenesis RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	A body shape index ( 34021172) Appendicular lean mass ( 33097823) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		45 interacting genes: ATF7IP BCL2L15 C22orf15 CIB3 CNTNAP2 DDX54 DES DUSP29 EIF3D EIF4A3 EWSR1 FNDC4 FOSL2 GPKOW HOXC5 KIF5B LMO2 MAPK1 MCM3AP MCPH1 MYOD1 NOTCH2NLA NTRK2 OSGIN1 PARVG POLR1C POLR2A POLR2C POLR2D POLR2E POLR2F POLR2H PRKRA PSMB8 RPAP1 TAF15 TNNC1 TRAPPC2L TRIM14 TRIM68 TSEN15 UPRT VHL WHR1 ZNF410	11 interacting genes: CTBP2 DVL3 GORASP2 LHX3 LHX4 PBX1 PBX2 PBX4 POLR2G POU6F2 ZBTB16
Entrez ID		5436	3222
HPRD ID		15995	00859
Ensembl ID		ENSG00000168002	ENSG00000172789
Uniprot IDs		P62487	Q00444
PDB IDs		2C35 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6DRD 6O9L 6XRE 7LBM 9EHZ 9EI1 9EI3 9EI4
Enriched GO Terms of Interacting Partners?		DNA-directed RNA Polymerase Complex RNA Polymerase II, Core Complex DNA-directed RNA Polymerase Activity RNA Polymerase I Complex RNA Polymerase III Complex Nucleoplasm Transcription By RNA Polymerase II DNA-templated Transcription Nucleus Cerebral Cortex Development Nucleolus RNA Metabolic Process Nucleobase-containing Compound Biosynthetic Process Nucleic Acid Binding Cellular Response To Brain-derived Neurotrophic Factor Stimulus Outer Ear Morphogenesis Macromolecule Biosynthetic Process Transcription Coregulator Activity TRNA Transcription By RNA Polymerase III TRNA Transcription Contractile Muscle Fiber Macromolecule Metabolic Process Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Striatum Development Transcription By RNA Polymerase I DNA Binding	Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Medial Motor Column Neuron Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Chromatin Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coregulator Binding Positive Regulation Of Transcription By RNA Polymerase II Transcription Corepressor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Animal Organ Morphogenesis Positive Regulation Of Metabolic Process Regulation Of Gene Expression Embryonic Limb Morphogenesis Regionalization DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process DNA-binding Transcription Factor Activity Limb Morphogenesis RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Eye Development Cellular Developmental Process Regulation Of Macromolecule Metabolic Process Pattern Specification Process DNA Binding Animal Organ Development Anatomical Structure Morphogenesis Motor Neuron Axon Guidance Embryonic Organ Development Proximal/distal Pattern Formation Sequence-specific DNA Binding Sensory Organ Development Neuron Development DNA-binding Transcription Factor Binding Regulation Of Metabolic Process Cell Differentiation In Spinal Cord Placenta Development Brain Development Transcription Regulator Complex Developmental Process Transcription Repressor Complex
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