SNPH and XPA

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SNPH	XPA
Description		syntaphilin	XPA, DNA damage recognition and repair factor
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytoplasmic Microtubule Membrane Neuron Projection Synapse Presynapse	Nucleotide-excision Repair Factor 1 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Cytosol Nuclear Body
	Molecular Function	Protein Binding Syntaxin-1 Binding	DNA Binding Damaged DNA Binding Protein Binding Zinc Ion Binding Protein Domain Specific Binding Protein Homodimerization Activity Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Neurotransmitter Secretion Synaptic Vesicle Docking Neuron Differentiation	Nucleotide-excision Repair, DNA Damage Recognition DNA Repair Base-excision Repair Nucleotide-excision Repair DNA Damage Response Response To Oxidative Stress Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To UV Response To Toxic Substance UV Protection Regulation Of Autophagy Protein Localization To Nucleus Multicellular Organism Growth Positive Regulation Of Transcription Initiation By RNA Polymerase II UV-damage Excision Repair Nucleotide-excision Repair Involved In Interstrand Cross-link Repair
Pathways			Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Dual incision in TC-NER
Drugs
Diseases			Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Body mass index ( 28552196) Lean body mass ( 28552196) Response to cytadine analogues (cytosine arabinoside) ( 24483146)	Hypothyroidism ( 27182965) Obesity-related traits ( 23251661) Serum thyroid-stimulating hormone levels ( 24852370) Thyroid cancer (Papillary, radiation-related) ( 20350937)
Interacting Genes		6 interacting genes: ATP6V1H PRKACA RHBDD2 STUB1 STX1A XPA	51 interacting genes: ARID3A ATM ATR AURKA BMPR1A BUB1 CEP164 DDB1 DDB2 DLC1 DVL3 ERCC1 ERCC6 FBXW7 GPN1 GTF2E2 GTF2H1 HERC2 MEOX2 MLH1 MLH3 MSH2 MSH3 MUTYH NDEL1 NRAS PCNA PDGFRL PICK1 PMS2 POLR1C PRDM16 PRKDC PSMB1 RASSF1 RB1 RHOU RPA1 RPA2 RPA4 SKIL SMAD2 SNPH SRC STK11 TBC1D7 TRIM27 VPS26C XAB2 XPC ZNF655
Entrez ID		9751	7507
HPRD ID		16081	02045
Ensembl ID		ENSG00000101298	ENSG00000136936
Uniprot IDs		A0A3B3IRY9 O15079	P23025
PDB IDs			1D4U 1XPA 2JNW 6J44 6LAE 6RO4 7AD8 8EBT 8EBU 8EBX 8EBY
Enriched GO Terms of Interacting Partners?		Regulation Of Autophagy Regulation Of Macroautophagy Cellular Response To Heat Response To Heat Proteasomal Protein Catabolic Process Myosin Head/neck Binding Nucleotide-excision Repair, DNA Damage Recognition Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Chaperone-mediated Protein Complex Assembly ERAD Pathway Regulation Of Hormone Levels Regulation Of Steroid Metabolic Process Kinase Binding Regulation Of System Process Nucleotide-excision Repair Involved In Interstrand Cross-link Repair Cellular Response To Stress Intracellular Signal Transduction Response To Temperature Stimulus Regulation Of Insulin Secretion Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Proteolysis Involved In Protein Catabolic Process Protein Localization To Lipid Droplet Regulation Of Muscle Contraction Protein Catabolic Process Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Positive Regulation Of Norepinephrine Secretion Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Nucleotide-excision Repair Factor 1 Complex Negative Regulation Of Vascular Associated Smooth Muscle Contraction Ubiquitin Conjugating Enzyme Complex CAMP-dependent Protein Kinase Complex Regulation Of Hormone Secretion Regulation Of Peptide Hormone Secretion Cellular Response To Parathyroid Hormone Stimulus Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Glucagon Stimulus Regulation Of Blood Circulation Protein Domain Specific Binding CAMP-dependent Protein Kinase Activity Interleukin-2-mediated Signaling Pathway Regulation Of Muscle System Process Cellular Response To Epinephrine Stimulus High-density Lipoprotein Particle Assembly Cytoplasmic Vesicle Macromolecule Catabolic Process Mitochondrial Protein Catabolic Process Regulation Of Protein Secretion CAMP/PKA Signal Transduction Nucleotide-activated Protein Kinase Complex	DNA Damage Response DNA Repair Mismatch Repair DNA Metabolic Process Cellular Response To Stress Nucleotide-excision Repair Chromosome Organization Nucleoplasm Nucleic Acid Metabolic Process Regulation Of Cell Cycle Phase Transition ATP-dependent DNA Damage Sensor Activity Damaged DNA Binding Response To UV Single-stranded DNA Binding Response To Stress Negative Regulation Of Cell Cycle Phase Transition Somatic Cell DNA Recombination Mismatched DNA Binding DNA Recombination Chromosome, Telomeric Region Nucleus DNA Binding Cellular Response To UV Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Process DNA Damage Checkpoint Signaling Somatic Recombination Of Immunoglobulin Gene Segments Double-strand Break Repair Cellular Response To Light Stimulus Cellular Response To Radiation Regulation Of Cell Cycle Process MutSalpha Complex Binding MutLalpha Complex Binding Somatic Diversification Of Immunoglobulins Response To Radiation Negative Regulation Of Cell Cycle Negative Regulation Of DNA Metabolic Process Regulation Of Cell Cycle Pyrimidine Dimer Repair Negative Regulation Of Mitotic Cell Cycle Signal Transduction In Response To DNA Damage Regulation Of DNA Metabolic Process Telomere Maintenance UV-damage Excision Repair Histone H2AXS139 Kinase Activity Dinucleotide Insertion Or Deletion Binding Regulation Of Mitotic Cell Cycle Protein Localization To Chromosome Response To Light Stimulus Regulation Of Mitotic Cell Cycle Phase Transition
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