CD79B and ZAP70

Number of citations of the paper that reports this interaction (PMID 12393534)
51

Data Source:
HPRD (in vitro)

		CD79B	ZAP70
Gene Name		CD79b molecule, immunoglobulin-associated beta	zeta-chain (TCR) associated protein kinase 70kDa
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane B Cell Receptor Complex Extracellular Vesicular Exosome	Immunological Synapse Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane T Cell Receptor Complex Membrane Raft
	Molecular Function	Transmembrane Signaling Receptor Activity	Phosphotyrosine Binding Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding
	Biological Process	Immune Response Signal Transduction B Cell Receptor Signaling Pathway	Adaptive Immune Response Protein Phosphorylation Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Migration Peptidyl-tyrosine Phosphorylation T Cell Differentiation Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation T Cell Activation B Cell Activation Beta Selection Positive Thymic T Cell Selection Negative Thymic T Cell Selection Innate Immune Response Positive Regulation Of T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway T Cell Aggregation T Cell Migration
Pathways		Signaling by the B Cell Receptor (BCR) Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Adaptive Immune System	TCR signaling Generation of second messenger molecules Translocation of ZAP-70 to Immunological synapse Adaptive Immune System
Drugs			Staurosporine
Diseases
GWAS
Protein-Protein Interactions		13 interactors: BLK CD19 CD3E CD5 CD79A FYN LCK LYN PTK2 PTPN6 SGTA SYK ZAP70	58 interactors: ABL1 ACP1 ANAPC11 APP ASB3 CARD11 CBL CBLB CBLC CD247 CD3E CD5 CD79B CRK CSK DBNL DEF6 DUSP3 EGFR ERBB3 FCGR3A FCRL3 FYN GAB2 GRB2 IFNAR1 LAT LAX1 LCK LCP2 MUC1 NDUFB8 NFAM1 NR0B2 PAG1 PLCG1 PRLR PTK2B PTPN22 PTPN3 PTPN6 PTPRC RASA1 SH2B3 SH3BP2 SHB SHC1 SIT1 SLA SLA2 SLAMF6 SOS1 TUBA1A TUBA4A TUBB TYROBP VAV1 WIPF1
Entrez ID		974	7535
HPRD ID		00922	01495
Ensembl ID		ENSG00000007312	ENSG00000115085
Uniprot IDs		P40259	P43403
PDB IDs		3KG5	1FBV 1M61 1U59 2CBL 2OQ1 2OZO 2Y1N 3ZNI 4A4B 4A4C 4K2R
Enriched GO Terms of Interacting Partners?		Antigen Receptor-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway B Cell Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Regulation Of Immune System Process Regulation Of Immune Response Regulation Of Cell-cell Adhesion Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Positive Regulation Of Cell-cell Adhesion Peptidyl-tyrosine Phosphorylation Regulation Of T Cell Activation Positive Regulation Of Cell Activation T Cell Costimulation Enzyme Linked Receptor Protein Signaling Pathway Protein Autophosphorylation Regulation Of Cell Adhesion Positive Regulation Of Cell Adhesion Immune System Process Regulation Of Lymphocyte Activation Regulation Of Cell Activation Leukocyte Activation Innate Immune Response Homotypic Cell-cell Adhesion Leukocyte Differentiation Hemopoiesis Platelet Activation Lymphocyte Activation Immune System Development Leukocyte Migration Lymphocyte Differentiation Positive Regulation Of Intracellular Signal Transduction Immune Response Fc Receptor Signaling Pathway Defense Response Single Organismal Cell-cell Adhesion T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Regulation Of Cell Adhesion Mediated By Integrin Peptidyl-amino Acid Modification Cellular Response To Peptide Hormone Stimulus Leukocyte Cell-cell Adhesion	Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune System Process Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Cell Activation Positive Regulation Of Immune System Process Innate Immune Response Immune Response Positive Regulation Of Immune Response Signal Transduction Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Regulation Of Lymphocyte Activation Regulation Of Cell Activation Defense Response Fc Receptor Signaling Pathway Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signaling Regulation Of Signaling Regulation Of T Cell Activation Cell Communication Regulation Of Cell-cell Adhesion Cellular Response To Stimulus Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway ERBB Signaling Pathway Response To Stimulus Leukocyte Activation T Cell Receptor Signaling Pathway Intracellular Signal Transduction Lymphocyte Activation Platelet Activation Blood Coagulation Regulation Of Intracellular Signal Transduction Hemostasis T Cell Costimulation Fc-epsilon Receptor Signaling Pathway Regulation Of Body Fluid Levels Homotypic Cell-cell Adhesion Response To Stress Wound Healing Single Organismal Cell-cell Adhesion T Cell Aggregation T Cell Activation Lymphocyte Aggregation
Tagcloud ?		abc capillary card11 constitutes deregulation diffuse dlbcl employing ezh2 gcb germinal gold hallmarks harbor harboring hotspot hotspots immunochemotherapy l265p mediastinal myd88 pmbl pmbls pose pyrosequencing thoroughly unlike utilizing vital	cd3 coimmunoprecipitated compartment cytosol detergent failing grb2 hsos1 insoluble jurkat localize nonidet p145 p21ras p36 p95 participates particulate phospholipase phosphoprotein plc redistributed shc tcr vav vicinity zeta
Tagcloud (Difference) ?		abc capillary card11 constitutes deregulation diffuse dlbcl employing ezh2 gcb germinal gold hallmarks harbor harboring hotspot hotspots immunochemotherapy l265p mediastinal myd88 pmbl pmbls pose pyrosequencing thoroughly unlike utilizing vital	cd3 coimmunoprecipitated compartment cytosol detergent failing grb2 hsos1 insoluble jurkat localize nonidet p145 p21ras p36 p95 participates particulate phospholipase phosphoprotein plc redistributed shc tcr vav vicinity zeta
Tagcloud (Intersection) ?