CD79B and FOXJ1

Data Source: HiPPIP (Novel)

		CD79B	FOXJ1
Name		CD79b molecule	forkhead box J1
Structure			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane B Cell Receptor Complex Extracellular Exosome IgM B Cell Receptor Complex	Chromatin Nucleus
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding
	Biological Process	Adaptive Immune Response Immune System Process Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Response To Bacterium B Cell Differentiation B Cell Receptor Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Central Tolerance Induction Negative Regulation Of Germinal Center Formation Positive Regulation Of Central B Cell Tolerance Induction Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Humoral Immune Response Spermatogenesis Determination Of Left/right Symmetry Pattern Specification Process Brain Development Heart Development Intracellular Protein Localization Cell Projection Organization Actin Cytoskeleton Organization Regulation Of Epithelial Cell Differentiation Ciliary Basal Body Organization Negative Regulation Of Interleukin-6 Production Negative Regulation Of T Cell Differentiation In Thymus Axoneme Assembly Establishment Of Apical/basal Cell Polarity Metanephric Part Of Ureteric Bud Development Negative Regulation Of T Cell Proliferation Motile Cilium Assembly Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Negative Regulation Of B Cell Activation Leukocyte Migration Cilium Assembly Lung Epithelium Development Epithelium Development Left/right Pattern Formation Glomerular Parietal Epithelial Cell Development Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Lung Ciliated Cell Differentiation
Pathways		CD22 mediated BCR regulation Potential therapeutics for SARS Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	None
Drugs		Polatuzumab vedotin	None
Diseases		Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8	None
GWAS		Height ( 25282103 ) Hip circumference adjusted for BMI ( 34021172 )	No GWAS studies recorded
Novel Interactors		2 novel interactors: FOXJ1 PDZD11	9 novel interactors: ATP10A CD79B CDK3 FBXO22 FKBP1A GATA6 PECAM1 PRKCA SMURF2
Interacting Genes		14 interacting genes: BLK CD19 CD3E CD5 CD79A FYN LCK LYN PTK2 PTPN6 SGTA SGTB SYK ZAP70	8 interacting genes: NMRAL1 OIP5 RFX2 RPUSD1 SLC37A3 THRA TRMT6 TWF2
Entrez ID		974	2302
HPRD ID		00922	03798
Ensembl ID		ENSG00000007312	ENSG00000129654
Uniprot IDs		P40259	Q92949
PDB IDs		3KG5 7WSO 7WSP 7XQ8 7XT6	Not available
GO Terms Enriched among Interactors		Antigen Receptor-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Immune Response-regulating Signaling Pathway Activation Of Immune Response B Cell Receptor Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Regulation Of Immune Response T Cell Costimulation Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Protein Tyrosine Kinase Activity Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Immune System Process Regulation Of T Cell Activation Positive Regulation Of T Cell Activation Regulation Of Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Lymphocyte Activation Fc-gamma Receptor Signaling Pathway Immune System Process Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Protein Phosphorylation Regulation Of Cell Adhesion Leukocyte Activation Regulation Of Cell Adhesion Mediated By Integrin Phosphorylation Lymphocyte Proliferation Positive Regulation Of Cell Activation Mononuclear Cell Proliferation Fc Receptor Signaling Pathway Cell Activation Leukocyte Proliferation Regulation Of Leukocyte Proliferation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Adaptive Immune Response Positive Regulation Of Cell Adhesion Fc Receptor Mediated Stimulatory Signaling Pathway Membrane Raft T Cell Receptor Signaling Pathway Leukocyte Migration SH2 Domain Binding Regulation Of Mononuclear Cell Proliferation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Phosphotyrosine Residue Binding	None