CD79B and PTPN6

Number of citations of the paper that reports this interaction (PMID 7539038)
44

Data Source:
HPRD (in vivo)

		CD79B	PTPN6
Gene Name		CD79b molecule, immunoglobulin-associated beta	protein tyrosine phosphatase, non-receptor type 6
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane B Cell Receptor Complex Extracellular Vesicular Exosome	Nucleus Nucleolus Cytoplasm Cytosol Cell-cell Junction Membrane Alpha-beta T Cell Receptor Complex Extracellular Vesicular Exosome
	Molecular Function	Transmembrane Signaling Receptor Activity	Phosphotyrosine Binding Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding SH3 Domain Binding Protein Kinase Binding SH2 Domain Binding
	Biological Process	Immune Response Signal Transduction B Cell Receptor Signaling Pathway	Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Protein Dephosphorylation Apoptotic Process G-protein Coupled Receptor Signaling Pathway Blood Coagulation Cell Proliferation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Cell Differentiation Platelet Formation T Cell Costimulation Abortive Mitotic Cell Cycle Positive Regulation Of Cell Adhesion Mediated By Integrin Peptidyl-tyrosine Dephosphorylation Megakaryocyte Development Negative Regulation Of T Cell Proliferation Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of MAP Kinase Activity Regulation Of B Cell Differentiation Negative Regulation Of Peptidyl-tyrosine Phosphorylation B Cell Receptor Signaling Pathway Negative Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Leukocyte Migration Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Signaling by the B Cell Receptor (BCR) Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Adaptive Immune System	Costimulation by the CD28 family Signaling by SCF-KIT Interferon gamma signaling Regulation of KIT signaling Interleukin receptor SHC signaling Interferon alpha/beta signaling Regulation of IFNA signaling Interferon Signaling Cytokine Signaling in Immune system Signal regulatory protein (SIRP) family interactions Cell surface interactions at the vascular wall PECAM1 interactions Signaling by Interleukins Platelet homeostasis Platelet sensitization by LDL Interleukin receptor SHC signaling PD-1 signaling Interleukin-2 signaling Interleukin-3, 5 and GM-CSF signaling Regulation of IFNG signaling Growth hormone receptor signaling Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: BLK CD19 CD3E CD5 CD79A FYN LCK LYN PTK2 PTPN6 SGTA SYK ZAP70	98 interactors: ABL1 ACTN1 ACTN4 BCR BLNK BTLA C6orf25 CAV1 CBL CD22 CD247 CD300LF CD33 CD5 CD72 CD79A CD79B CEACAM1 CLEC4A CSF2RB CTNNB1 CTNND1 CUZD1 CXCR4 DOK1 EGFR EPOR ESR1 FAS FCGR2B FCRL3 FHL3 FLT3 GAB2 GHR GRB2 HOXA10 IFNAR1 IL2RB IL4R IL6ST INSR IRS2 IRS4 JAK1 JAK2 JAK3 KDR KHDRBS1 KIR2DL3 KIR2DL5A KIT KLRAP1 KLRB1 KLRC1 LAIR1 LCK LCP2 LIFR LILRB2 LILRB4 LYN MS4A2 MYH9 NOS1 PAG1 PECAM1 PIK3R1 PILRA PILRB PRKCA PRKCD PTK2B PTPN11 PTPRC ROS1 SHC1 SIGLEC10 SIGLEC11 SIGLEC12 SIRPA SLAMF6 SOS1 SPATA2 SRC SSTR2 STAT5B STAT6 SYK TFG TLR10 TMEM62 TNFRSF1A TRAF6 TREML1 TYK2 VAV1 ZAP70
Entrez ID		974	5777
HPRD ID		00922	01475
Ensembl ID		ENSG00000007312	ENSG00000111679
Uniprot IDs		P40259	P29350 Q53XS4
PDB IDs		3KG5	1FPR 1GWZ 1X6C 2B3O 2RMX 2YU7 3PS5 4GRY 4GRZ 4GS0 4HJP 4HJQ
Enriched GO Terms of Interacting Partners?		Antigen Receptor-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway B Cell Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Regulation Of Immune System Process Regulation Of Immune Response Regulation Of Cell-cell Adhesion Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation Positive Regulation Of Cell-cell Adhesion Peptidyl-tyrosine Phosphorylation Regulation Of T Cell Activation Positive Regulation Of Cell Activation T Cell Costimulation Enzyme Linked Receptor Protein Signaling Pathway Protein Autophosphorylation Regulation Of Cell Adhesion Positive Regulation Of Cell Adhesion Immune System Process Regulation Of Lymphocyte Activation Regulation Of Cell Activation Leukocyte Activation Innate Immune Response Homotypic Cell-cell Adhesion Leukocyte Differentiation Hemopoiesis Platelet Activation Lymphocyte Activation Immune System Development Leukocyte Migration Lymphocyte Differentiation Positive Regulation Of Intracellular Signal Transduction Immune Response Fc Receptor Signaling Pathway Defense Response Single Organismal Cell-cell Adhesion T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Regulation Of Cell Adhesion Mediated By Integrin Peptidyl-amino Acid Modification Cellular Response To Peptide Hormone Stimulus Leukocyte Cell-cell Adhesion	Cell Surface Receptor Signaling Pathway Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Immune System Process Immune System Process Signaling Enzyme Linked Receptor Protein Signaling Pathway Cell Communication Regulation Of Immune Response Cellular Response To Stimulus Regulation Of Cell Activation Cell Activation Response To Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Activation Positive Regulation Of Signal Transduction Immune Response Immune Response-regulating Signaling Pathway Defense Response Regulation Of Cell-cell Adhesion Cellular Response To Organic Substance Regulation Of Lymphocyte Activation Innate Immune Response Positive Regulation Of Immune System Process Response To Organic Substance Cell Migration Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cell Adhesion Blood Coagulation Hemostasis Cell Motility Regulation Of Cell Adhesion Positive Regulation Of T Cell Activation Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Peptidyl-tyrosine Phosphorylation Regulation Of Signal Transduction Cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of Body Fluid Levels Intracellular Signal Transduction Leukocyte Activation Leukocyte Differentiation Leukocyte Migration Fc Receptor Signaling Pathway Regulation Of Signaling Response To Cytokine Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Stress
Tagcloud ?		abc capillary card11 constitutes deregulation diffuse dlbcl employing ezh2 gcb germinal gold hallmarks harbor harboring hotspot hotspots immunochemotherapy l265p mediastinal myd88 pmbl pmbls pose pyrosequencing thoroughly unlike utilizing vital	a2 ag cd45 chimera chimeras chimeric coupling diminished enzymatic fails hcp hemopoietic initiated inositol j45 jurkat ligation lymphoid phosphatase phospholipase phosphotyrosine ptp1c rescue shp shptp surprisingly tcr transduction unlike
Tagcloud (Difference) ?		abc capillary card11 constitutes deregulation diffuse dlbcl employing ezh2 gcb germinal gold hallmarks harbor harboring hotspot hotspots immunochemotherapy l265p mediastinal myd88 pmbl pmbls pose pyrosequencing thoroughly utilizing vital	a2 ag cd45 chimera chimeras chimeric coupling diminished enzymatic fails hcp hemopoietic initiated inositol j45 jurkat ligation lymphoid phosphatase phospholipase phosphotyrosine ptp1c rescue shp shptp surprisingly tcr transduction
Tagcloud (Intersection) ?		unlike