VPRBP and ATR

Number of citations of the paper that reports this interaction (PMID 22184063)
5

Data Source:
BioGRID (enzymatic study)

		VPRBP	ATR
Gene Name		Vpr (HIV-1) binding protein	ATR serine/threonine kinase
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm COP9 Signalosome	XY Body Nucleoplasm Chromosome Golgi Apparatus PML Body
	Molecular Function	Protein Binding ATP Binding Histone Kinase Activity (H2A-T120 Specific)	DNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MutLalpha Complex Binding MutSalpha Complex Binding Protein Dimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Viral Process Protein Ubiquitination B Cell Differentiation V(D)J Recombination Cell Competition In A Multicellular Organism Histone H2A-T120 Phosphorylation	DNA Damage Checkpoint Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair Cellular Response To DNA Damage Stimulus Cell Cycle Multicellular Organismal Development Negative Regulation Of DNA Replication Peptidyl-serine Phosphorylation Cellular Response To Heat Cellular Response To UV Response To Drug Regulation Of Protein Binding Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Autophosphorylation Cellular Response To Gamma Radiation Replicative Senescence Regulation Of Cellular Response To Heat
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Fanconi Anemia pathway G2/M DNA damage checkpoint G2/M Checkpoints Meiotic synapsis Regulation of HSF1-mediated heat shock response Cellular response to heat stress Regulation of the Fanconi anemia pathway Activation of ATR in response to replication stress Cell Cycle Checkpoints
Drugs
Diseases
GWAS
Protein-Protein Interactions		14 interactors: ATM ATR HDAC1 HIST1H3A HIST3H3 KATNA1 MCM10 NF2 PRKDC RAG1 RBX1 TP53 UBE2D2 UNG	47 interactors: AATF ABL1 AP1B1 AP2A2 ARHGEF1 ATM ATRIP BLM BRCA1 BRCA2 CDKN2C CEP164 CHD4 CHEK1 CHEK2 CLSPN CREB1 DCLRE1C DTL E2F1 E4F1 EEF1E1 EP300 FANCA FANCD2 FLT1 H2AFX KDR LIG4 MCM2 MRE11A MSH2 NBN PA2G4 PIK3CA POLD1 POLN PPP2R2A PTS RAD17 RHEB TP53 TREX1 UPF1 VPRBP XPA XRCC5
Entrez ID		9730	545
HPRD ID		11674	08369
Ensembl ID			ENSG00000175054
Uniprot IDs		Q9Y4B6	Q13535
PDB IDs
Enriched GO Terms of Interacting Partners?		DNA Metabolic Process Response To Gamma Radiation Replicative Senescence DNA Recombination B Cell Differentiation V(D)J Recombination DNA Repair Chromosome Organization Response To Ionizing Radiation Organelle Organization DNA Damage Checkpoint Double-strand Break Repair B Cell Activation Regulation Of Signal Transduction By P53 Class Mediator Mitotic Cell Cycle Negative Regulation Of DNA Replication Nucleobase-containing Compound Metabolic Process Pre-B Cell Allelic Exclusion Cell Cycle Cellular Response To DNA Damage Stimulus Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To Ionizing Radiation Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint B Cell Lineage Commitment Negative Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Cell Cycle Checkpoint T Cell Differentiation In Thymus Cell Aging Lymphocyte Differentiation Mitotic G1 DNA Damage Checkpoint Telomere Maintenance Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Cellular Response To Stress Pre-B Cell Differentiation Somitogenesis Double-strand Break Repair Via Homologous Recombination Recombinational Repair Cell Cycle Process Nitrogen Compound Metabolic Process Response To Abiotic Stimulus Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Somite Development Immature B Cell Differentiation Response To Hypoxia	Cellular Response To DNA Damage Stimulus DNA Repair DNA Metabolic Process Cellular Response To Stress Cell Cycle Process Cell Cycle DNA Damage Checkpoint Double-strand Break Repair DNA Replication Cell Cycle Checkpoint DNA Recombination Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Stress Regulation Of Cell Cycle Response To Ionizing Radiation Mitotic Cell Cycle Nitrogen Compound Metabolic Process Response To Radiation Negative Regulation Of Cell Cycle Mitotic Cell Cycle Process Regulation Of Mitotic Cell Cycle G2 DNA Damage Checkpoint Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cellular Response To Stimulus Intrinsic Apoptotic Signaling Pathway Chromosome Organization Negative Regulation Of Mitotic Cell Cycle Response To Abiotic Stimulus Apoptotic Signaling Pathway Double-strand Break Repair Via Homologous Recombination Recombinational Repair Organelle Organization Response To Stimulus Cell Cycle Arrest Negative Regulation Of DNA Metabolic Process Response To X-ray Mitotic DNA Integrity Checkpoint Mitotic Cell Cycle Checkpoint Signal Transduction By P53 Class Mediator Telomere Maintenance Cellular Macromolecule Biosynthetic Process Cellular Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of DNA Replication B Cell Activation Signal Transduction In Response To DNA Damage Biosynthetic Process
Tagcloud ?		a3g accessory antiviral apobec3g computer crosstalk degradation disarmed downregulated encapsidation encountered existence highlight hiv hostile immunoprecipitation implicates intervene ligase observation proteasomal replication restricting screen unveiling versatility vif virion	activators breakage broad chromatin chromosome comprises concept defect discuss emerging exert heterochromatin hybrid inherited mediate member modulating mr numerous observations remodelling repair retardation seems segregation snf2 somehow thalaessemia xnp
Tagcloud (Difference) ?		a3g accessory antiviral apobec3g computer crosstalk degradation disarmed downregulated encapsidation encountered existence highlight hiv hostile immunoprecipitation implicates intervene ligase observation proteasomal replication restricting screen unveiling versatility vif virion	activators breakage broad chromatin chromosome comprises concept defect discuss emerging exert heterochromatin hybrid inherited mediate member modulating mr numerous observations remodelling repair retardation seems segregation snf2 somehow thalaessemia xnp
Tagcloud (Intersection) ?