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DCAF1 and ATR
Number of citations of the paper that reports this interaction (PubMedID
22184063
)
38
Data Source:
BioGRID
(enzymatic study)
DCAF1
ATR
Description
DDB1 and CUL4 associated factor 1
ATR checkpoint kinase
Image
GO Annotations
Cellular Component
Fibrillar Center
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Cytoskeleton
COP9 Signalosome
Cul4-RING E3 Ubiquitin Ligase Complex
Chromosome, Telomeric Region
Nucleus
Nuclear Envelope
Nucleoplasm
Chromosome
Golgi Apparatus
PML Body
ATR-ATRIP Complex
Site Of DNA Damage
Molecular Function
Nucleotide Binding
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Nuclear Estrogen Receptor Binding
Protein Serine Kinase Activity
Histone H2AT120 Kinase Activity
Ubiquitin-like Ligase-substrate Adaptor Activity
Nucleotide Binding
DNA Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
MutLalpha Complex Binding
MutSalpha Complex Binding
Histone H2AXS139 Kinase Activity
Protein Serine Kinase Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Chromatin Organization
Chromatin Remodeling
Protein Ubiquitination
B Cell Differentiation
V(D)J Recombination
Cell Competition In A Multicellular Organism
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Post-translational Protein Modification
Positive Regulation Of Protein Catabolic Process
Base-excision Repair, AP Site Formation Via Deaminated Base Removal
DNA Damage Checkpoint Signaling
G2/M Transition Of Mitotic Cell Cycle
Telomere Maintenance
Nucleobase-containing Compound Metabolic Process
DNA Replication
DNA Repair
Double-strand Break Repair
Chromatin Remodeling
DNA Damage Response
Nuclear Envelope Organization
Negative Regulation Of DNA Replication
Response To Xenobiotic Stimulus
Response To Mechanical Stimulus
Replication Fork Processing
Positive Regulation Of Telomere Maintenance Via Telomerase
Cellular Response To UV
Interstrand Cross-link Repair
Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Mitotic G2/M Transition Checkpoint
Response To Arsenic-containing Substance
Nuclear Membrane Disassembly
Protein Localization To Chromosome, Telomeric Region
Cellular Response To Gamma Radiation
Regulation Of Cellular Response To Stress
Replicative Senescence
Establishment Of RNA Localization To Telomere
Establishment Of Protein-containing Complex Localization To Telomere
DNA Strand Resection Involved In Replication Fork Processing
Regulation Of Cellular Response To Heat
Positive Regulation Of Telomerase Catalytic Core Complex Assembly
Protein Localization To Site Of Double-strand Break
Regulation Of Double-strand Break Repair
Pathways
Antigen processing: Ubiquitination & Proteasome degradation
Meiotic synapsis
Activation of ATR in response to replication stress
Regulation of HSF1-mediated heat shock response
HDR through Single Strand Annealing (SSA)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Fanconi Anemia Pathway
TP53 Regulates Transcription of DNA Repair Genes
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Impaired BRCA2 binding to RAD51
Drugs
Ceralasertib
Diseases
Alveolar rhabdomyosarcoma
Seckel syndrome
GWAS
Asthma (
32296059
)
Eosinophil count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Mean corpuscular hemoglobin (
29403010
32888494
)
Mean corpuscular volume (
29403010
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Red blood cell count (
27863252
29403010
32888494
)
Red cell distribution width (
28957414
32888494
)
Reticulocyte count (
27863252
)
Reticulocyte fraction of red cells (
27863252
)
Interacting Genes
25 interacting genes:
ATM
ATR
CCP110
CD274
EXO1
FOXM1
H3-3A
H3-4
H3C1
HLTF
IRF1
KATNA1
LATS1
LATS2
NF2
PLK4
PRKDC
PWP1
PYGO2
RAG1
TET2
TP53
UBE2D2
UBE2D3
USP2
58 interacting genes:
AATF
ABL1
AP1B1
AP3B1
APBB1
ARHGEF1
ATM
BLM
BRCA1
BRCA2
CDKN2C
CEP164
CHD4
CHEK1
CHEK2
CHUK
CLSPN
CREB1
DCAF1
DCLRE1C
DTL
E2F1
E4F1
EEF1E1
EP300
ETAA1
ETV1
FANCA
FANCD2
FANCI
FLT1
H2AX
KDR
LIG4
MCM2
MCPH1
MRE11
MSH2
NBN
NFE2L2
PA2G4
PARP1
PIK3CA
POLD1
POLN
PPP2R3A
RAD17
RASSF1
RHEB
RPA1
TP53
TREX1
UHRF1
UHRF2
UPF1
USP2-AS1
XPA
XRCC5
Entrez ID
9730
545
HPRD ID
11674
08369
Ensembl ID
ENSG00000145041
ENSG00000175054
Uniprot IDs
Q9Y4B6
Q13535
PDB IDs
3WA0
4CC9
4P7I
4PXW
4Z8L
5AJA
5JK7
6N45
6ZUE
6ZX9
7OKQ
7SSE
7UFV
7V7B
7V7C
8F8E
8OG5
8OG6
8OG7
8OG8
8OG9
8OGA
8OGB
8OGC
8OO5
8OOD
9B9H
9B9T
9B9W
9BA2
9BHR
9BHS
9C1Q
9D4E
9DLW
5YZ0
Enriched GO Terms of Interacting Partners
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Histone H2AXS139 Kinase Activity
Nucleus
Chromatin Organization
Regulation Of Cell Cycle
Positive Regulation Of Cellular Component Biogenesis
DNA Binding
DNA Repair
Somatic Cell DNA Recombination
Chromosome Organization
Nucleoplasm
DNA Metabolic Process
DNA Strand Resection Involved In Replication Fork Processing
Replicative Senescence
Telomere Organization
Response To Gamma Radiation
Establishment Of RNA Localization To Telomere
Establishment Of Protein-containing Complex Localization To Telomere
Positive Regulation Of Telomerase Catalytic Core Complex Assembly
Signal Transduction In Response To DNA Damage
V(D)J Recombination
Chromatin Remodeling
Centrosome
DNA-dependent Protein Kinase Activity
Chromosome, Telomeric Region
Inner Cell Mass Cell Fate Commitment
Inner Cell Mass Cellular Morphogenesis
Cellular Response To Gamma Radiation
Protein Serine Kinase Activity
Negative Regulation Of Cell Cycle
Positive Regulation Of Protein-containing Complex Assembly
Pre-B Cell Allelic Exclusion
DNA Damage Response
DNA Damage Checkpoint Signaling
Macromolecule Metabolic Process
ATP Binding
Nucleotide Binding
Protein Serine/threonine Kinase Activity
Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of T Cell Apoptotic Process
Regulation Of Signal Transduction By P53 Class Mediator
Replication Fork Processing
B Cell Lineage Commitment
Regulation Of Protein-containing Complex Assembly
Regulation Of Organelle Assembly
Regulation Of Telomere Maintenance Via Telomerase
T Cell Differentiation In Thymus
Response To Radiation
Regulation Of Hippo Signaling
Somitogenesis
DNA Damage Response
DNA Repair
DNA Metabolic Process
Cellular Response To Stress
Nucleic Acid Metabolic Process
Double-strand Break Repair
Signal Transduction In Response To DNA Damage
DNA Damage Checkpoint Signaling
Chromosome, Telomeric Region
Mitotic DNA Damage Checkpoint Signaling
Nucleobase-containing Compound Metabolic Process
Mitotic DNA Integrity Checkpoint Signaling
DNA Recombination
Negative Regulation Of Cell Cycle Phase Transition
Response To Stress
Regulation Of Cell Cycle Phase Transition
Negative Regulation Of Cell Cycle Process
Negative Regulation Of Cell Cycle
Regulation Of Mitotic Cell Cycle
Macromolecule Metabolic Process
Regulation Of Cell Cycle
Negative Regulation Of Mitotic Cell Cycle
Nucleoplasm
Recombinational Repair
Response To Ionizing Radiation
Regulation Of Cell Cycle Process
Response To Radiation
Damaged DNA Binding
Double-strand Break Repair Via Homologous Recombination
Mitotic G2/M Transition Checkpoint
Cellular Response To Radiation
Chromosome Organization
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Cell Cycle G2/M Phase Transition
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Regulation Of Primary Metabolic Process
Response To Gamma Radiation
Nucleus
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Cell Cycle G2/M Phase Transition
Mitotic G2 DNA Damage Checkpoint Signaling
Negative Regulation Of Mitotic Cell Cycle Phase Transition
DNA Binding
Intracellular Signal Transduction
Regulation Of Macromolecule Metabolic Process
Telomere Maintenance
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Cellular Response To Ionizing Radiation
Positive Regulation Of Metabolic Process
Regulation Of Mitotic Cell Cycle Phase Transition
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Tagcloud (Intersection)
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