DCAF1 and HLTF

Number of citations of the paper that reports this interaction (PubMedID 29079575)
44

Data Source:
BioGRID (enzymatic study)

		DCAF1	HLTF
Description		DDB1 and CUL4 associated factor 1	helicase like transcription factor
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GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Centrosome Cytoskeleton COP9 Signalosome Cul4-RING E3 Ubiquitin Ligase Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Plasma Membrane Membrane Nuclear Matrix Nuclear Replication Fork RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Nucleotide Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Nuclear Estrogen Receptor Binding Protein Serine Kinase Activity Histone H2AT120 Kinase Activity Ubiquitin-like Ligase-substrate Adaptor Activity	Nucleotide Binding Nucleic Acid Binding DNA Binding Single-stranded DNA Binding RNA Binding Catalytic Activity Helicase Activity Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Zinc Ion Binding DNA Translocase Activity Transferase Activity Hydrolase Activity Hydrolase Activity, Acting On Acid Anhydrides, In Phosphorus-containing Anhydrides Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Protein Ubiquitination B Cell Differentiation V(D)J Recombination Cell Competition In A Multicellular Organism Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Positive Regulation Of Protein Catabolic Process Base-excision Repair, AP Site Formation Via Deaminated Base Removal	Protein Polyubiquitination DNA Repair Chromatin Organization DNA Damage Response Protein Ubiquitination MRNA Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neurogenesis Replication Fork Reversal
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Asthma ( 32296059)
Interacting Genes		25 interacting genes: ATM ATR CCP110 CD274 EXO1 FOXM1 H3-3A H3-4 H3C1 HLTF IRF1 KATNA1 LATS1 LATS2 NF2 PLK4 PRKDC PWP1 PYGO2 RAG1 TET2 TP53 UBE2D2 UBE2D3 USP2	14 interacting genes: CDK9 CEBPA DCAF1 EEF1G EWSR1 HSPA8 SP1 SP3 SULT1C2 UBC UBE2A UBE2V2 UBE2Z WBP4
Entrez ID		9730	6596
HPRD ID		11674	04461
Ensembl ID		ENSG00000145041	ENSG00000071794
Uniprot IDs		Q9Y4B6	A0A0C4DGA6 A8K5B6 Q05BZ6 Q14527
PDB IDs		3WA0 4CC9 4P7I 4PXW 4Z8L 5AJA 5JK7 6N45 6ZUE 6ZX9 7OKQ 7SSE 7UFV 7V7B 7V7C 8F8E 8OG5 8OG6 8OG7 8OG8 8OG9 8OGA 8OGB 8OGC 8OO5 8OOD 9B9H 9B9T 9B9W 9BA2 9BHR 9BHS 9C1Q 9D4E 9DLW	2MZN 4HRE 4HRH 4S0N 4XZF 4XZG 5BNH 5K5F 6KCS
Enriched GO Terms of Interacting Partners?		Histone H2AXS139 Kinase Activity Nucleus Chromatin Organization Regulation Of Cell Cycle Positive Regulation Of Cellular Component Biogenesis DNA Binding DNA Repair Somatic Cell DNA Recombination Chromosome Organization Nucleoplasm DNA Metabolic Process DNA Strand Resection Involved In Replication Fork Processing Replicative Senescence Telomere Organization Response To Gamma Radiation Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Positive Regulation Of Telomerase Catalytic Core Complex Assembly Signal Transduction In Response To DNA Damage V(D)J Recombination Chromatin Remodeling Centrosome DNA-dependent Protein Kinase Activity Chromosome, Telomeric Region Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis Cellular Response To Gamma Radiation Protein Serine Kinase Activity Negative Regulation Of Cell Cycle Positive Regulation Of Protein-containing Complex Assembly Pre-B Cell Allelic Exclusion DNA Damage Response DNA Damage Checkpoint Signaling Macromolecule Metabolic Process ATP Binding Nucleotide Binding Protein Serine/threonine Kinase Activity Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Macromolecule Metabolic Process Regulation Of T Cell Apoptotic Process Regulation Of Signal Transduction By P53 Class Mediator Replication Fork Processing B Cell Lineage Commitment Regulation Of Protein-containing Complex Assembly Regulation Of Organelle Assembly Regulation Of Telomere Maintenance Via Telomerase T Cell Differentiation In Thymus Response To Radiation Regulation Of Hippo Signaling Somitogenesis	Nucleoplasm Nucleus Host-mediated Perturbation Of Viral Transcription Host-mediated Activation Of Viral Transcription Granulocyte Differentiation Embryonic Placenta Development Protein Ubiquitination Protein Modification By Small Protein Conjugation Host-mediated Activation Of Viral Process Post-translational Protein Modification Postreplication Repair Ubiquitin Conjugating Enzyme Activity Nucleic Acid Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Protein Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Chaperone-mediated Autophagy Translocation Complex Disassembly Positive Regulation Of Hydrogen Sulfide Biosynthetic Process Protein-DNA Complex Cellular Response To Wortmannin Histone H2AT120 Kinase Activity Cell Competition In A Multicellular Organism Cellular Response To Stress Macromolecule Metabolic Process Modification-dependent Protein Catabolic Process Macromolecule Catabolic Process Protein Modification Process Transcription Cis-regulatory Region Binding Transcription Repressor Complex P-TEFb Complex Response To Vitamin B2 C/EBP Complex Lumenal Side Of Lysosomal Membrane Response To Wortmannin Cholesterol Sulfotransferase Activity Error-free Postreplication DNA Repair Host-mediated Perturbation Of Viral Process Ubiquitin Protein Ligase Binding Proteolysis Involved In Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Mononuclear Cell Differentiation DNA Metabolic Process Positive Regulation Of Protein Localization To Chromatin CHOP-C/EBP Complex Regulation Of Protein Import UBC13-MMS2 Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process ATP Binding Regulation Of Nucleobase-containing Compound Metabolic Process
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