DCAF1 and PLK4

Number of citations of the paper that reports this interaction (PubMedID 39456880)
53

Data Source:
BioGRID (protein complementation assay)

		DCAF1	PLK4
Description		DDB1 and CUL4 associated factor 1	polo like kinase 4
Image
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Centrosome Cytoskeleton COP9 Signalosome Cul4-RING E3 Ubiquitin Ligase Complex	XY Body Nucleus Nucleolus Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Cleavage Furrow Deuterosome Procentriole Procentriole Replication Complex
	Molecular Function	Nucleotide Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Nuclear Estrogen Receptor Binding Protein Serine Kinase Activity Histone H2AT120 Kinase Activity Ubiquitin-like Ligase-substrate Adaptor Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Protein Ubiquitination B Cell Differentiation V(D)J Recombination Cell Competition In A Multicellular Organism Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Positive Regulation Of Protein Catabolic Process Base-excision Repair, AP Site Formation Via Deaminated Base Removal	Protein Phosphorylation Centriole Replication Regulation Of Cell Cycle Process Positive Regulation Of Centriole Replication Cilium Assembly Trophoblast Giant Cell Differentiation De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs			Fostamatinib
Diseases
GWAS		Asthma ( 32296059)
Interacting Genes		25 interacting genes: ATM ATR CCP110 CD274 EXO1 FOXM1 H3-3A H3-4 H3C1 HLTF IRF1 KATNA1 LATS1 LATS2 NF2 PLK4 PRKDC PWP1 PYGO2 RAG1 TET2 TP53 UBE2D2 UBE2D3 USP2	25 interacting genes: ACTR2 AIRIM ARR3 BTRC CHD3 CYLD DCAF1 DNAJB13 DRC4 ELOA MIR126 MTUS2 OSBPL3 PRDM16 SFN SMAD4 SPAG5 TAX1BP3 TEC TENT5B TENT5C TFIP11 TGFBR1 TRIM54 ZBTB39
Entrez ID		9730	10733
HPRD ID		11674	10387
Ensembl ID		ENSG00000145041	ENSG00000142731
Uniprot IDs		Q9Y4B6	O00444
PDB IDs		3WA0 4CC9 4P7I 4PXW 4Z8L 5AJA 5JK7 6N45 6ZUE 6ZX9 7OKQ 7SSE 7UFV 7V7B 7V7C 8F8E 8OG5 8OG6 8OG7 8OG8 8OG9 8OGA 8OGB 8OGC 8OO5 8OOD 9B9H 9B9T 9B9W 9BA2 9BHR 9BHS 9C1Q 9D4E 9DLW	2N19 3COK 4JXF 4N7V 4N7Z 4N9J 4YUR 4YYP 5LHY 5LHZ 6N45 6N46 6W38 6W3I 6W3J 8XPG
Enriched GO Terms of Interacting Partners?		Histone H2AXS139 Kinase Activity Nucleus Chromatin Organization Regulation Of Cell Cycle Positive Regulation Of Cellular Component Biogenesis DNA Binding DNA Repair Somatic Cell DNA Recombination Chromosome Organization Nucleoplasm DNA Metabolic Process DNA Strand Resection Involved In Replication Fork Processing Replicative Senescence Telomere Organization Response To Gamma Radiation Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Positive Regulation Of Telomerase Catalytic Core Complex Assembly Signal Transduction In Response To DNA Damage V(D)J Recombination Chromatin Remodeling Centrosome DNA-dependent Protein Kinase Activity Chromosome, Telomeric Region Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis Cellular Response To Gamma Radiation Protein Serine Kinase Activity Negative Regulation Of Cell Cycle Positive Regulation Of Protein-containing Complex Assembly Pre-B Cell Allelic Exclusion DNA Damage Response DNA Damage Checkpoint Signaling Macromolecule Metabolic Process ATP Binding Nucleotide Binding Protein Serine/threonine Kinase Activity Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Macromolecule Metabolic Process Regulation Of T Cell Apoptotic Process Regulation Of Signal Transduction By P53 Class Mediator Replication Fork Processing B Cell Lineage Commitment Regulation Of Protein-containing Complex Assembly Regulation Of Organelle Assembly Regulation Of Telomere Maintenance Via Telomerase T Cell Differentiation In Thymus Response To Radiation Regulation Of Hippo Signaling Somitogenesis	Cytoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Centrosome Cytoskeleton Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Microtubule Negative Regulation Of Cell Population Proliferation Positive Regulation Of Extracellular Matrix Assembly Endothelial Cell Activation Poly(A) RNA Polymerase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process I-SMAD Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Positive Regulation Of T Cell Receptor Signaling Pathway Microtubule Binding Regulation Of Extracellular Matrix Assembly Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Extracellular Matrix Organization Microtubule-based Process Regulation Of Cytoskeleton Organization Activin Receptor Signaling Pathway Cardiac Epithelial To Mesenchymal Transition Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Centriolar Satellite Regulation Of Primary Metabolic Process Ciliary Basal Body Phosphoprotein Binding Negative Regulation Of Interleukin-18-mediated Signaling Pathway Regulation Of Wnt Signaling Pathway Met1-linked Polyubiquitin Deubiquitinase Activity Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Histone H2AT120 Kinase Activity Cell Competition In A Multicellular Organism Neuron Fate Commitment Ventricular Septum Morphogenesis Nucleus Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of DNA-templated Transcription Negative Regulation Of Wnt Signaling Pathway
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