CD63 and ITGA6

Number of citations of the paper that reports this interaction (PubMedID 7629079)
0

Data Source:
HPRD (in vitro)

		CD63	ITGA6
Description		CD63 molecule	integrin subunit alpha 6
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Lysosome Lysosomal Membrane Endosome Late Endosome Multivesicular Body Plasma Membrane Cell Surface Endosome Membrane Membrane Platelet Dense Granule Membrane Late Endosome Membrane Endosome Lumen Vesicle Multivesicular Body Membrane Protein-containing Complex Azurophil Granule Membrane Melanosome Extracellular Exosome Multivesicular Body, Internal Vesicle	Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Membrane Integrin Alpha6-beta1 Complex Integrin Alpha6-beta4 Complex
	Molecular Function	Protein Binding Protein-containing Complex Binding	Protein Binding Insulin-like Growth Factor I Binding Signaling Receptor Activity Neuregulin Binding Cadherin Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Receptor Internalization Cell-matrix Adhesion Negative Regulation Of Epithelial Cell Migration Protein Transport Cell Migration Cell Differentiation Epithelial Cell Differentiation Endosome To Melanosome Transport Pigmentation Positive Regulation Of Cell Adhesion Positive Regulation Of Endocytosis Pigment Granule Maturation Pigment Cell Differentiation Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Integrin-mediated Signaling Pathway	Cell-substrate Junction Assembly Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Ectodermal Cell Differentiation Positive Regulation Of Neuron Projection Development Positive Regulation Of Cell Migration Cell-substrate Adhesion Nail Development Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Skin Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Leukocyte Migration Cell-cell Adhesion Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Platelet degranulation Neutrophil degranulation	Assembly of collagen fibrils and other multimeric structures Basigin interactions Integrin cell surface interactions Integrin cell surface interactions Laminin interactions Laminin interactions Syndecan interactions Type I hemidesmosome assembly Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Alveolar Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells
Drugs
Diseases			Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA)
GWAS		Advanced age-related macular degeneration ( 26691988) Cardiac Troponin-T levels ( 31014085) Refractive error ( 32231278)	Alzheimer's disease biomarkers ( 23419831) Diabetic kidney disease ( 26305897) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Food allergy ( 29030101) Metabolite levels ( 23823483) Peanut allergy ( 29030101) Prostate cancer ( 19767753 31562322)
Interacting Genes		18 interacting genes: AP4M1 CD82 CD9 F2RL1 GLP1R HLA-DMB HLA-DRA ITGA6 PI4K2A PTGFRN SDC1 SDCBP SLC22A1 SLC22A2 SRF TIMP1 TMEM80 VKORC1	23 interacting genes: ADAM9 APP BIN1 CALM1 CANX CD151 CD36 CD63 CD82 COL17A1 GIPC1 GRB2 ITGB1 ITGB4 LGALS3BP PCSK5 PLEC PRKCD PXN RABIF RPSA TSPAN4 USP40
Entrez ID		967	3655
HPRD ID		01121	00945
Ensembl ID		ENSG00000135404	ENSG00000091409
Uniprot IDs		P08962	A0A8C8KBL6 A0AAQ5BID9 P23229
PDB IDs			7CEB 7CEC
Enriched GO Terms of Interacting Partners?		Myoblast Fusion Involved In Skeletal Muscle Regeneration Positive Regulation Of Extracellular Exosome Assembly Acetylcholine Transport Pyrimidine Nucleoside Transmembrane Transporter Activity Epinephrine Transport Spermidine Transmembrane Transport Putrescine Transport Spermidine Transmembrane Transporter Activity Putrescine Transmembrane Transporter Activity Acetylcholine Transmembrane Transporter Activity Spermidine Transport Thiamine Transmembrane Transporter Activity Thiamine Transport Quaternary Ammonium Group Transmembrane Transporter Activity Thiamine Transmembrane Transport Regulation Of Extracellular Exosome Assembly Norepinephrine Uptake Xenobiotic Transport Across Blood-brain Barrier Toxin Transmembrane Transporter Activity Polyamine Transmembrane Transport Membrane Serotonin Uptake Norepinephrine Transport Prostaglandin Transmembrane Transporter Activity Monoamine Transmembrane Transporter Activity Organic Cation Transmembrane Transporter Activity Catecholamine Uptake Dopamine Uptake Azole Transmembrane Transport Serotonin Transport Skin Morphogenesis Quaternary Ammonium Group Transport Prostaglandin Transport Pyrimidine-containing Compound Transmembrane Transport Positive Regulation Of Exocytosis Peptide Antigen Assembly With MHC Class II Protein Complex Positive Regulation Of Exosomal Secretion MHC Class II Protein Complex Neurotransmitter Transmembrane Transporter Activity Vitamin Transmembrane Transport Organic Anion Transmembrane Transporter Activity Regulation Of Exosomal Secretion Regulation Of Body Fluid Levels Dopamine Transport Neurotransmitter Reuptake Xenobiotic Transmembrane Transporter Activity MHC Class II Protein Complex Binding Regulation Of Cell Migration Myoblast Fusion Monoamine Transport	Cell Adhesion Integrin Binding Cell-substrate Adhesion Hemidesmosome Assembly Hemidesmosome Cell-matrix Adhesion Extracellular Exosome Focal Adhesion Cell Migration Endocytosis Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Endocytosis Plasma Membrane Laminin Binding Membrane Cell Motility Positive Regulation Of Transport Regulation Of Superoxide Metabolic Process Cell Adhesion Mediated By Integrin Vesicle-mediated Transport Low-density Lipoprotein Particle Mediated Signaling Import Into Cell Cell Surface Cell-substrate Junction Assembly Cell-substrate Junction Organization Regulation Of Spontaneous Synaptic Transmission Presynaptic Endocytosis Regulation Of Reactive Oxygen Species Metabolic Process Cell-cell Adhesion Mediated By Integrin Regulation Of Endocytosis Regulation Of Action Potential Cellular Response To Hydroperoxide Positive Regulation Of Cellular Component Organization Positive Regulation Of Supramolecular Fiber Organization Leukocyte Activation Receptor-mediated Endocytosis Vesicle Regulation Of Transport Receptor Internalization Receptor Complex Regulation Of Supramolecular Fiber Organization Insulin Receptor Substrate Binding Cell-cell Junction Response To Manganese Ion Anchoring Junction Cell Activation Mesodermal Cell Differentiation Endothelial Cell Migration Positive Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Biological Quality
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