CD63 and TIMP1

Number of citations of the paper that reports this interaction (PMID 16917503)
51

Data Source:
HPRD (two hybrid, in vivo)

		CD63	TIMP1
Gene Name		CD63 molecule	TIMP metallopeptidase inhibitor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Endosome Membrane Platelet Dense Granule Membrane Intrinsic Component Of Plasma Membrane Late Endosome Membrane Endosome Lumen Melanosome Extracellular Vesicular Exosome Multivesicular Body, Internal Vesicle	Extracellular Region Proteinaceous Extracellular Matrix Basement Membrane Extracellular Space Platelet Alpha Granule Lumen Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Protease Binding Cytokine Activity Protein Binding Growth Factor Activity Metalloendopeptidase Inhibitor Activity Metal Ion Binding
	Biological Process	Positive Regulation Of Receptor Internalization Platelet Degranulation Cell-matrix Adhesion Blood Coagulation Protein Transport Cell Migration Platelet Activation Cellular Protein Localization Endosome To Melanosome Transport Pigment Granule Maturation Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Rubidium Ion Transport Positive Regulation Of Integrin-mediated Signaling Pathway	Platelet Degranulation Aging Blood Coagulation Positive Regulation Of Cell Proliferation Response To Hormone Negative Regulation Of Endopeptidase Activity Extracellular Matrix Disassembly Platelet Activation Extracellular Matrix Organization Response To Cytokine Negative Regulation Of Apoptotic Process Response To Peptide Hormone Negative Regulation Of Metalloenzyme Activity Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Trophoblast Cell Migration Regulation Of Integrin-mediated Signaling Pathway
Pathways		Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation	Response to elevated platelet cytosolic Ca2+ Activation of Matrix Metalloproteinases Platelet degranulation Platelet activation, signaling and aggregation Degradation of the extracellular matrix
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: AP4M1 CD82 CD9 HLA-DMB HLA-DRA ITGA6 PI4K2A PTGFRN SDC1 SDCBP SRF TIMP1 VKORC1	8 interactors: CD63 ECH1 EEF1B2 MMP1 MMP2 MMP3 MYOC RECQL5
Entrez ID		967	7076
HPRD ID		01121	02371
Ensembl ID		ENSG00000135404	ENSG00000102265
Uniprot IDs		P08962	B4DJK3 P01033 Q6FGX5
PDB IDs			1D2B 1LQN 1OO9 1UEA 2J0T 3MA2 3V96
Enriched GO Terms of Interacting Partners?		Wound Healing Response To Wounding Blood Coagulation Positive Regulation Of Extracellular Vesicular Exosome Assembly Hemostasis Peptide Antigen Assembly With MHC Class II Protein Complex Regulation Of Extracellular Vesicular Exosome Assembly MHC Class II Protein Complex Assembly Regulation Of Body Fluid Levels Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Positive Regulation Of Organelle Assembly Platelet Activation Cell Junction Assembly Cellular Component Assembly Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion Myoblast Differentiation Cell Activation Positive Regulation Of Exocytosis Positive Regulation Of Cellular Component Biogenesis Response To Stress Basophil Degranulation Contractile Actin Filament Bundle Assembly Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Exocytosis Platelet Degranulation Response To Stimulus Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Basophil Activation Polysaccharide Assembly With MHC Class II Protein Complex Myoblast Development Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Negative Regulation Of Beta-amyloid Clearance Negative Regulation Of Trophoblast Cell Migration Cell-cell Junction Assembly Secretion By Cell Establishment Of Localization In Cell Odontogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Regulation Of Exocytosis Immune System Process Striated Muscle Cell Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Heart Development Positive Regulation Of Transcription By Glucose	Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Positive Regulation Of Protein Oligomerization Regulation Of Protein Oligomerization Positive Regulation Of Cellular Component Biogenesis Cellular Response To Amino Acid Stimulus Extracellular Matrix Organization Extracellular Structure Organization ERBB2-ERBB3 Signaling Pathway Skeletal Muscle Hypertrophy Response To Amino Acid ERBB2 Signaling Pathway Regulation Of Protein Kinase B Signaling Negative Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Protein Complex Assembly Cellular Response To Acid Chemical Regulation Of Rubidium Ion Transport Catabolic Process Non-canonical Wnt Signaling Pathway Via JNK Cascade Non-canonical Wnt Signaling Pathway Via MAPK Cascade Regulation Of Cellular Component Organization Response To Stress Positive Regulation Of Oxidative Stress-induced Cell Death Clustering Of Voltage-gated Sodium Channels Pigment Granule Maturation Endosome To Melanosome Transport Intramembranous Ossification Skeletal Muscle Adaptation Bone Trabecula Formation Positive Regulation Of Integrin-mediated Signaling Pathway Cellular Pigment Accumulation Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Mitochondrial Depolarization Negative Regulation Of Stress Fiber Assembly Ossification Neuronal Ion Channel Clustering Blood Vessel Maturation Negative Regulation Of Actin Filament Bundle Assembly Cellular Response To Nitric Oxide Regulation Of Protein Complex Assembly Response To Nitric Oxide Bone Trabecula Morphogenesis Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Regulation Of Mitochondrial Depolarization Positive Regulation Of Receptor Internalization Negative Regulation Of DNA-templated Transcription, Elongation
Tagcloud ?		acquire apply candidates catabolic cathepsin cathepsins colocalization compartments documents endosomal eventually follows golgi gun hete limp lysosomal mediator proform proteolysis scatters secretable secretory shot sorting storage supposed triggers unstimulated	accurately another applying associations biomarker biomarkers candidate classifying divide egfr embedded escc esophageal ihc kit multivariate p110alpha p85alpha panel paraffin pi3k poor prognosis prognostic risks six squamous statistical subgroups
Tagcloud (Difference) ?		acquire apply candidates catabolic cathepsin cathepsins colocalization compartments documents endosomal eventually follows golgi gun hete limp lysosomal mediator proform proteolysis scatters secretable secretory shot sorting storage supposed triggers unstimulated	accurately another applying associations biomarker biomarkers candidate classifying divide egfr embedded escc esophageal ihc kit multivariate p110alpha p85alpha panel paraffin pi3k poor prognosis prognostic risks six squamous statistical subgroups
Tagcloud (Intersection) ?