CD63 and CD9

Number of citations of the paper that reports this interaction (PMID 12175627)
11

Data Source:
HPRD (in vivo)

		CD63	CD9
Gene Name		CD63 molecule	CD9 molecule
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Endosome Membrane Platelet Dense Granule Membrane Intrinsic Component Of Plasma Membrane Late Endosome Membrane Endosome Lumen Melanosome Extracellular Vesicular Exosome Multivesicular Body, Internal Vesicle	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Apical Plasma Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Platelet Alpha Granule Membrane Vesicle Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Integrin Binding Protein Binding
	Biological Process	Positive Regulation Of Receptor Internalization Platelet Degranulation Cell-matrix Adhesion Blood Coagulation Protein Transport Cell Migration Platelet Activation Cellular Protein Localization Endosome To Melanosome Transport Pigment Granule Maturation Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Rubidium Ion Transport Positive Regulation Of Integrin-mediated Signaling Pathway	Platelet Degranulation Movement Of Cell Or Subcellular Component Cell Adhesion Single Fertilization Fusion Of Sperm To Egg Plasma Membrane Brain Development Blood Coagulation Negative Regulation Of Cell Proliferation Pathogenesis Response To Water Deprivation Oligodendrocyte Development Platelet Activation Paranodal Junction Assembly Multicellular Organism Reproduction
Pathways		Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation	Uptake and actions of bacterial toxins Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation Fertilization Sperm:Oocyte Membrane Binding Uptake and function of diphtheria toxin
Drugs
Diseases
GWAS			Mean platelet volume ( 22139419) Paclitaxel-induced neuropathy ( 23776197) Platelet counts ( 22139419)
Protein-Protein Interactions		13 interactors: AP4M1 CD82 CD9 HLA-DMB HLA-DRA ITGA6 PI4K2A PTGFRN SDC1 SDCBP SRF TIMP1 VKORC1	22 interactors: ADAM2 ADRB2 CD19 CD36 CD38 CD53 CD59 CD63 CD81 CLN8 HBEGF IGSF8 ITGA2 ITGA3 ITGA5 ITGB1 KIT PRKCA PTGFRN SERPINH1 TSPAN4 VKORC1
Entrez ID		967	928
HPRD ID		01121	00880
Ensembl ID		ENSG00000135404	ENSG00000010278
Uniprot IDs		P08962	B4DK09 P21926
PDB IDs
Enriched GO Terms of Interacting Partners?		Wound Healing Response To Wounding Blood Coagulation Positive Regulation Of Extracellular Vesicular Exosome Assembly Hemostasis Peptide Antigen Assembly With MHC Class II Protein Complex Regulation Of Extracellular Vesicular Exosome Assembly MHC Class II Protein Complex Assembly Regulation Of Body Fluid Levels Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Positive Regulation Of Organelle Assembly Platelet Activation Cell Junction Assembly Cellular Component Assembly Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion Myoblast Differentiation Cell Activation Positive Regulation Of Exocytosis Positive Regulation Of Cellular Component Biogenesis Response To Stress Basophil Degranulation Contractile Actin Filament Bundle Assembly Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Exocytosis Platelet Degranulation Response To Stimulus Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Basophil Activation Polysaccharide Assembly With MHC Class II Protein Complex Myoblast Development Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Negative Regulation Of Beta-amyloid Clearance Negative Regulation Of Trophoblast Cell Migration Cell-cell Junction Assembly Secretion By Cell Establishment Of Localization In Cell Odontogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Regulation Of Exocytosis Immune System Process Striated Muscle Cell Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Heart Development Positive Regulation Of Transcription By Glucose	Wound Healing Blood Coagulation Hemostasis Response To Wounding Regulation Of Body Fluid Levels Response To Stress Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Cellular Component Movement Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Adhesion Integrin-mediated Signaling Pathway Regulation Of Immune System Process Regulation Of Protein Metabolic Process Learning Or Memory Cognition Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cell Adhesion Mediated By Integrin Positive Regulation Of Cell Proliferation Cell Migration Cell Adhesion Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Regulation Of Cell Migration Extracellular Matrix Organization Associative Learning Extracellular Structure Organization Locomotion Cell Motility Positive Regulation Of Signal Transduction Regulation Of Cell Adhesion Positive Regulation Of Epithelial Cell Migration Regulation Of Cellular Amino Acid Metabolic Process Tissue Development Cell-substrate Adhesion Positive Regulation Of Endocytosis Leukocyte Migration Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Phosphorylation Single-organism Behavior Mesodermal Cell Differentiation Movement Of Cell Or Subcellular Component Positive Regulation Of Cell-substrate Adhesion Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling
Tagcloud ?		acquire apply candidates catabolic cathepsin cathepsins colocalization compartments documents endosomal eventually follows golgi gun hete limp lysosomal mediator proform proteolysis scatters secretable secretory shot sorting storage supposed triggers unstimulated	accessibility agvhd allergy allobmt analogous buffy cationic cd23 cd25 clarified coat destructive dr eg2 eosinophil eosinophilia eosinophilic eosinophils epitope fog formaldehyde intravenously methylprednisolone myristate octylglucopyranoside pbes recognizing rhil transplanted
Tagcloud (Difference) ?		acquire apply candidates catabolic cathepsin cathepsins colocalization compartments documents endosomal eventually follows golgi gun hete limp lysosomal mediator proform proteolysis scatters secretable secretory shot sorting storage supposed triggers unstimulated	accessibility agvhd allergy allobmt analogous buffy cationic cd23 cd25 clarified coat destructive dr eg2 eosinophil eosinophilia eosinophilic eosinophils epitope fog formaldehyde intravenously methylprednisolone myristate octylglucopyranoside pbes recognizing rhil transplanted
Tagcloud (Intersection) ?