SAFB2 and SORBS3

Number of citations of the paper that reports this interaction (PMID 12660241)
17

Data Source:
HPRD (in vitro, in vivo)

		SAFB2	SORBS3
Gene Name		scaffold attachment factor B2	sorbin and SH3 domain containing 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome	Nucleus Cytosol Cytoskeleton Focal Adhesion
	Molecular Function	Nucleotide Binding DNA Binding Protein Binding Identical Protein Binding Poly(A) RNA Binding	Structural Constituent Of Cytoskeleton Protein Binding Transcription Factor Binding Vinculin Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription From RNA Polymerase II Promoter Muscle Contraction Actin Filament Organization Cell Adhesion Cell-substrate Adhesion Positive Regulation Of MAPK Cascade Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Stress Fiber Assembly
Pathways			Smooth Muscle Contraction
Drugs
Diseases
GWAS		vWF and FVIII levels ( 21810271)	HIV-1 control ( 20205591)
Protein-Protein Interactions		8 interactors: CHGB ESR1 FNTA FUS GIT2 SAFB SORBS3 ZSCAN18	46 interactors: ABL1 ADAM15 ADAMTSL4 AKT1 ARNT2 CBLB CPNE2 CPSF7 DDX17 DIP2A DLG5 DMRTB1 DVL2 EFS EIF3H FAM154A FASLG FLOT1 HNRNPK HNRNPUL1 INPPL1 KIAA0408 KIAA1217 MAPK1 MAPK3 NCKIPSD NOTCH3 PAK1 PAK2 PAK7 RBMX SAFB2 SH2D4A SOCS7 SRCIN1 TBC1D22B TRIM23 TRIM27 TRIM41 VARS2 VPS37B VPS37C ZBED1 ZBTB25 ZBTB7B ZC4H2
Entrez ID		9667	10174
HPRD ID		06424	11535
Ensembl ID		ENSG00000130254	ENSG00000120896
Uniprot IDs		Q14151	O60504
PDB IDs			2CT3 2DLM 2NWM 2YUP
Enriched GO Terms of Interacting Partners?		Intracellular Estrogen Receptor Signaling Pathway Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Tubulin Deacetylation Prostate Epithelial Cord Elongation Positive Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Protein Farnesylation Hormone Metabolic Process Regulation Of Tubulin Deacetylation Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Deacetylase Activity Branch Elongation Involved In Mammary Gland Duct Branching Antral Ovarian Follicle Growth Neurotransmitter Receptor Metabolic Process Protein Geranylgeranylation Regulation Of Branching Involved In Prostate Gland Morphogenesis Mammary Gland Branching Involved In Pregnancy Regulation Of Hormone Levels Positive Regulation Of Hydrolase Activity Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Positive Regulation Of Cellular Metabolic Process Vagina Development Uterus Development Protein Prenylation Regulation Of Signal Transduction Regulation Of Metabolic Process Positive Regulation Of Nitric-oxide Synthase Activity Cellular Response To Estradiol Stimulus Prostate Gland Growth Branching Involved In Prostate Gland Morphogenesis Mammary Gland Epithelial Cell Proliferation Female Genitalia Development Behavioral Response To Pain Regulation Of Signaling Positive Regulation Of Monooxygenase Activity Branch Elongation Of An Epithelium Positive Regulation Of Catalytic Activity Positive Regulation Of Protein Deacetylation Regulation Of Rhodopsin Mediated Signaling Pathway Cellular Response To Estrogen Stimulus RNA Metabolic Process Growth	Gene Expression Regulation Of Cellular Amino Acid Metabolic Process Transcription, DNA-templated Regulation Of Cellular Ketone Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process RNA Biosynthetic Process Regulation Of Metabolic Process Fc Receptor Signaling Pathway Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Process Negative Regulation Of Protein Kinase Activity Intracellular Signal Transduction Negative Regulation Of Kinase Activity Regulation Of Protein Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway RNA Metabolic Process Regulation Of Protein Tyrosine Kinase Activity Biosynthetic Process Regulation Of Gene Expression Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Innate Immune Response Response To Insulin Immune Response Regulation Of Protein Phosphorylation Negative Regulation Of Transferase Activity Response To Epidermal Growth Factor Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Kinase Activity Regulation Of Golgi Inheritance Negative Regulation Of Protein Phosphorylation Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Caveolin-mediated Endocytosis Cellular Response To Insulin Stimulus Cell Morphogenesis Involved In Differentiation Protein Autophosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Tyrosine Kinase Activity Regulation Of Nitrogen Compound Metabolic Process Regulation Of Phosphorus Metabolic Process
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