SAFB2 and SIRPA

Number of citations of the paper that reports this interaction (PubMedID 19299420)
73

Data Source:
BioGRID (pull down)

		SAFB2	SIRPA
Description		scaffold attachment factor B2	signal regulatory protein alpha
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Body Extracellular Exosome	Plasma Membrane Cell Surface Membrane Extracellular Exosome Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Nucleic Acid Binding DNA Binding RNA Binding Protein Binding Identical Protein Binding Sequence-specific DNA Binding	Protein Phosphatase Inhibitor Activity Protein Binding SH3 Domain Binding Protein Phosphatase Binding GTPase Regulator Activity Protein Binding Involved In Heterotypic Cell-cell Adhesion Cell-cell Adhesion Mediator Activity Protein Antigen Binding Protein Tyrosine Kinase Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Regulation Of MRNA Processing Sertoli Cell Differentiation Regulation Of Androgen Receptor Signaling Pathway	Cell Adhesion Regulation Of Gene Expression Cell Migration Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Type II Interferon Production Regulation Of Interleukin-1 Beta Production Regulation Of Interleukin-6 Production Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Interferon-beta Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion Monocyte Extravasation Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of JNK Cascade Negative Regulation Of Inflammatory Response Negative Regulation Of Phagocytosis Positive Regulation Of Phagocytosis Positive Regulation Of T Cell Activation Cellular Response To Hydrogen Peroxide Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Type II Interferon Cellular Response To Interleukin-1 Cellular Response To Interleukin-12 Negative Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Cell-cell Adhesion Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways			Cell surface interactions at the vascular wall Signal regulatory protein family interactions Signal regulatory protein family interactions Neutrophil degranulation
Drugs
Diseases
GWAS		Creativity ( 32133506) Obsessive-compulsive symptoms ( 26859814) vWF and FVIII levels ( 21810271)	Aortic root size ( 21223598) Basophil percentage of granulocytes ( 27863252) Blood protein levels ( 30072576) High light scatter reticulocyte count ( 32888494) Liver enzyme levels (alanine transaminase) ( 24124411) Mean platelet volume ( 19820697 22139419 27863252 32888494) Platelet count ( 29403010) Platelet distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		14 interacting genes: CEBPA CHGB ERBB2 ESR1 FNTA FUS FXR1 GIT2 RNF10 SAFB SIRPA SORBS3 SUMO2 ZSCAN18	60 interacting genes: ACTN1 AKT1 ARF4 ARHGEF6 CALR CAPZB CCDC57 CD47 CD81 CDK16 COL6A2 DDX10 DYNLT1 EIF5B ELOA FLNA FTH1 FUBP1 GNL1 HSF2BP HSP90AB1 HSP90B1 HSPA4 HSPA5 HSPA8 HSPA9 IGF1R IL1RAP JAK2 KRT10 KRT15 KRT2 KRT31 KRT34 KRT40 KTN1 MATK MT-ND1 MX1 NEK1 NEXN NOL3 NUCB1 PFN1 PHYH PPM1B PSMA6 PSMC5 PTPN11 PTPN6 PTPN7 RPS8 SAFB2 SMG7 SOS1 TBX3 TRIM2 TRIM23 TRIM27 VIM
Entrez ID		9667	140885
HPRD ID		06424	03912
Ensembl ID		ENSG00000130254	ENSG00000198053
Uniprot IDs		Q14151	P78324
PDB IDs			2JJS 2JJT 2UV3 2WNG 4CMM 6BIT 6NMR 6NMS 6NMT 6NMU 6NMV 7KPG 7ST5 7YGG
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Positive Regulation Of Rho Protein Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Small GTPase Mediated Signal Transduction Estrogen Receptor Signaling Pathway Presynaptic Cytosol Postsynaptic Cytosol Regulation Of Inflammatory Response Neuromuscular Junction Development Chromatin Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Molecular Condensate Scaffold Activity RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Peptide Pheromone Maturation Presynapse Glutamatergic Synapse Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Cell Development Regulation Of Metabolic Process Regulation Of Signal Transduction Receptor Tyrosine Kinase Binding Regulation Of Nitric Oxide Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Response To Vitamin B2 C/EBP Complex ERBB3:ERBB2 Complex Protein-containing Complex Localization CAAX-protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Complex Protein Farnesyltransferase Activity Protein Farnesyltransferase Complex Cellular Response To Interleukin-12 Negative Regulation Of Multicellular Organismal Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Negative Regulation Of MRNA Catabolic Process Positive Regulation Of Metabolic Process	Extracellular Exosome Focal Adhesion Supramolecular Fiber Organization ATP-dependent Protein Folding Chaperone Cytosol Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Protein Folding Chaperone Structural Constituent Of Skin Epidermis Cytoplasm Keratin Filament Nucleotide Binding Intermediate Filament Unfolded Protein Binding Structural Molecule Activity Cytoskeleton Organization Protein Folding Protein Folding In Endoplasmic Reticulum Non-membrane Spanning Protein Tyrosine Phosphatase Activity Maintenance Of Location Plasma Membrane Bounded Cell Projection Organization Organelle Organization Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Cadherin Binding T Cell Costimulation Protein Metabolic Process Protein Binding Platelet Formation Regulation Of Nitric Oxide Biosynthetic Process RNA Binding Response To Interleukin-12 Megakaryocyte Development Epidermal Growth Factor Receptor Signaling Pathway Macromolecule Metabolic Process Heat Shock Protein Binding Regulation Of Nitric Oxide Metabolic Process Epithelial Cell Differentiation ATP Binding MHC Class II Protein Complex Binding Cell Projection Organization Sequestering Of Calcium Ion Nuclear Receptor-mediated Corticosteroid Signaling Pathway Protein Refolding Regulation Of Apoptotic Process Maintenance Of Location In Cell Protein Modification Process Glutamatergic Synapse Cytoskeleton
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