CENPC and UBTF

Number of citations of the paper that reports this interaction (PubMedID 8702533)
0

Data Source:
HPRD (in vitro, in vivo)

		CENPC	UBTF
Description		centromere protein C	upstream binding transcription factor
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Chromosome, Centromeric Region Inner Kinetochore Nucleus Nucleoplasm Chromosome Pericentric Heterochromatin Cytosol Nuclear Body Midbody	Fibrillar Center Nucleus Nucleoplasm Nucleolus
	Molecular Function	DNA Binding Protein Binding Centromeric DNA Binding Identical Protein Binding	RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase I General Transcription Initiation Factor Activity DNA Binding Chromatin Binding RNA Binding Protein Binding Scaffold Protein Binding
	Biological Process	Mitotic Cell Cycle Chromosome Segregation Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Assembly Spindle Attachment To Meiosis I Kinetochore	RNA Polymerase I Preinitiation Complex Assembly Transcription By RNA Polymerase I Transcription Initiation At RNA Polymerase I Promoter Positive Regulation Of Transcription By RNA Polymerase I Regulation Of Glucose Mediated Signaling Pathway
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	NoRC negatively regulates rRNA expression RNA Polymerase I Promoter Opening RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adverse response to drug ( 30420678) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Walking pace ( 33128006)	Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Diverticular disease ( 30177863) hemolysis of donated blood (osmotic) ( 34014839) Mean corpuscular hemoglobin concentration ( 29403010) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		8 interacting genes: CIP2A DAXX ELOC MAPK14 MDC1 SUMO2 TRIM14 UBTF	37 interacting genes: AURKA CCNA2 CCND1 CCNE1 CDK2 CDK4 CEBPA CENPC CHGB CREBBP CSNK2A1 EP300 GSK3A IRS1 IRS2 LEF1 MAD1L1 MAPK1 MAPK3 MDM2 POLR1E POLR1G RB1 RBL2 RNF10 RUNX2 SERPINH1 SMURF1 TAF1 TAF1A TAF1B TAF1C TAF1D TBP TCOF1 USP7 ZMYM2
Entrez ID		1060	7343
HPRD ID		00315	02814
Ensembl ID		ENSG00000145241	ENSG00000108312
Uniprot IDs		Q03188	P17480
PDB IDs		5LSJ 5LSK 6MUO 6MUP 6SE6 6SEE 6SEF 7PII 7QOO 7R5R 7XHN 7XHO 7YWX 7YYH	1K99 1L8Y 1L8Z 2HDZ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Post-translational Protein Modification Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process DNA Damage Checkpoint Signaling Neuron Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Cellular Response To Diamide DNA-templated Transcription Initiation RNA Polymerase I Cis-regulatory Region Sequence-specific DNA Binding Broken Chromosome Clustering PML Body Regulation Of RNA Metabolic Process Regulation Of Synaptic Membrane Adhesion Regulation Of Macromolecule Metabolic Process Target-directed MiRNA Degradation Elongin Complex Regulation Of Glucose Mediated Signaling Pathway Signal Transduction In Response To DNA Damage Cellular Response To Sodium Arsenite RNA Polymerase I General Transcription Initiation Factor Activity Nucleoplasm NFAT Protein Binding Response To Sodium Arsenite Cellular Response To Salt Mitogen-activated Protein Kinase P38 Binding Regulation Of Metabolic Process Stress-induced Premature Senescence Protein-DNA Complex Assembly Chromosome Protein Modification By Small Protein Conjugation Cellular Response To Stress NLRP1 Inflammasome Complex Assembly Transcription Initiation At RNA Polymerase I Promoter Protein Modification Process RNA Polymerase I Core Promoter Sequence-specific DNA Binding DNA Damage Response Negative Regulation Of Cell Cycle Phase Transition RNA Polymerase I Preinitiation Complex Assembly	Transcription By RNA Polymerase I DNA-templated Transcription RNA Polymerase Transcription Factor SL1 Complex Nucleoplasm Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nucleus Transcription Regulator Complex Nucleobase-containing Compound Biosynthetic Process Regulation Of Proteasomal Protein Catabolic Process Transcription Initiation At RNA Polymerase I Promoter Regulation Of Cell Cycle Phase Transition Regulation Of DNA-templated Transcription Regulation Of Primary Metabolic Process Regulation Of RNA Biosynthetic Process Nucleic Acid Metabolic Process RNA Polymerase I Preinitiation Complex Assembly Regulation Of Proteolysis RNA Metabolic Process RNA Polymerase I Transcription Regulator Complex Positive Regulation Of Mitotic Cell Cycle Regulation Of Cell Population Proliferation Macromolecule Biosynthetic Process Positive Regulation Of Catabolic Process Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle Process Regulation Of RNA Metabolic Process Positive Regulation Of Cell Population Proliferation Cell Division Mitotic Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleolar Large RRNA Transcription By RNA Polymerase I Cell Cycle Phase Transition Regulation Of Macromolecule Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Protein Catabolic Process Regulation Of Protein Stability Gland Development DNA-binding Transcription Factor Binding Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle
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