GDA and DLG3

Number of citations of the paper that reports this interaction (PubMedID 10542258)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		GDA	DLG3
Description		guanine deaminase	discs large MAGUK scaffold protein 3
Image
GO Annotations	Cellular Component	Cytosol	Extracellular Space Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction Basolateral Plasma Membrane Neuromuscular Junction AMPA Glutamate Receptor Complex Neuron Projection Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Zinc Ion Binding Guanine Deaminase Activity Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds Metal Ion Binding	Protein Binding Kinase Binding Protein Kinase Binding Phosphatase Binding Ubiquitin Protein Ligase Binding Ionotropic Glutamate Receptor Binding
	Biological Process	Allantoin Metabolic Process Nucleobase-containing Compound Metabolic Process Guanine Catabolic Process Deoxyguanosine Catabolic Process Nervous System Development Amide Catabolic Process GMP Catabolic Process DGMP Catabolic Process Guanine Metabolic Process	Establishment Of Planar Polarity Chemical Synaptic Transmission Nervous System Development Negative Regulation Of Cell Population Proliferation Protein Localization To Synapse Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Localization To Synapse Cell-cell Adhesion Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Pathways		Purine catabolism	Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor NrCAM interactions Activation of Ca-permeable Kainate Receptor RAF/MAP kinase cascade Neurexins and neuroligins Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs
Diseases			Non-syndromic X-linked mental retardation
GWAS		Suicidal ideation ( 20877300)	Mean platelet volume ( 32888494)
Interacting Genes		4 interacting genes: DLG1 DLG3 DLG4 SNTA1	51 interacting genes: ABCA1 ADGRL1 AOAH APC ATP2B4 CACNG2 CALM1 CNKSR2 CRIPT DHRS11 DLG1 DLG4 DLGAP1 DLGAP3 DLGAP4 EIF4H ERBB4 EXOC4 EXOC7 GDA GLS2 GRIK2 GRIN1 GRIN2A GRIN2B GRIN2C GUCY1A2 KCNA4 KCNJ12 KCNJ2 KDELR1 KHDRBS1 KIF1B LIN7A LRP2 MAPK12 NLGN1 NLGN2 NLGN3 OGT OSBP2 PLEKHA2 PTK2B RPF2 RPS8 SCN4A SCN5A SEMA4C SNCA SYNGAP1 VTN
Entrez ID		9615	1741
HPRD ID		08849	02177
Ensembl ID		ENSG00000119125	ENSG00000082458
Uniprot IDs		Q9Y2T3	Q59FY1 Q92796
PDB IDs		2UZ9 3E0L 4AQL	1UM7 2FE5 2I1N
Enriched GO Terms of Interacting Partners?		Neuromuscular Junction Ionotropic Glutamate Receptor Binding Receptor Localization To Synapse Receptor Clustering Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Localization To Synapse Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Protein Localization To Cell Junction Kinase Binding Postsynaptic Density Membrane Establishment Or Maintenance Of Cell Polarity Adherens Junction Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane AMPA Glutamate Receptor Complex Protein Localization To Postsynaptic Membrane Chemical Synaptic Transmission Protein Localization To Postsynapse Protein Localization To Membrane Neuron Projection Trans-synaptic Signaling Regulation Of Sodium Ion Transmembrane Transport Synaptic Signaling Phosphatase Binding Regulation Of Membrane Potential Protein Kinase Binding Cell-cell Adhesion Synaptic Membrane Lateral Plasma Membrane Regulation Of Sodium Ion Transport Protein-containing Complex Localization Localization Within Membrane Regulation Of System Process Glutamatergic Synapse PDZ Domain Binding Nervous System Development Cell-cell Signaling Signaling Cell Communication P2Y1 Nucleotide Receptor Binding Sarcolemma Bicellular Tight Junction Transmembrane Transporter Binding Cell Adhesion Regulation Of Biological Quality Structural Constituent Of Postsynaptic Density L27 Domain Binding Beta-1 Adrenergic Receptor Binding Regulation Of Grooming Behavior System Development	Regulation Of Membrane Potential Positive Regulation Of Synaptic Transmission Positive Regulation Of Excitatory Postsynaptic Potential Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Transmission, Glutamatergic Glutamatergic Synapse Synapse Postsynaptic Membrane Postsynaptic Density Membrane Regulation Of Synaptic Transmission, Glutamatergic Postsynaptic Density Ionotropic Glutamate Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission Regulation Of System Process Ligand-gated Ion Channel Signaling Pathway Regulation Of Nervous System Process Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Regulation Of Neuronal Synaptic Plasticity Plasma Membrane Protein Localization To Synapse Trans-synaptic Signaling Synaptic Signaling NMDA Selective Glutamate Receptor Complex Regulation Of Monoatomic Ion Transmembrane Transport Protein Localization To Cell Junction Signaling Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Synaptic Plasticity Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Membrane Regulation Of Synapse Organization Regulation Of Synapse Assembly Scaffold Protein Binding Regulation Of Biological Quality Regulation Of Monoatomic Ion Transport NMDA Glutamate Receptor Activity Synapse Organization PDZ Domain Binding Cell Communication Receptor Clustering Regulation Of Signaling Regulation Of Cell Communication Glutamate-gated Calcium Ion Channel Activity Long-term Synaptic Potentiation Excitatory Chemical Synaptic Transmission Cell-cell Signaling Regulation Of Postsynaptic Membrane Potential Protein Localization To Membrane
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?