COL14A1 and DCN

Number of citations of the paper that reports this interaction (PMID 9252349)
10

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		COL14A1	DCN
Gene Name		collagen, type XIV, alpha 1	decorin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Proteinaceous Extracellular Matrix Collagen Trimer Collagen Type XIV Trimer Interstitial Matrix Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Extracellular Vesicular Exosome	Extracellular Region Proteinaceous Extracellular Matrix Collagen Type VI Trimer Extracellular Space Golgi Lumen Extracellular Matrix Lysosomal Lumen
	Molecular Function	Extracellular Matrix Structural Constituent Collagen Binding Protein Binding, Bridging Poly(A) RNA Binding	Collagen Binding Glycosaminoglycan Binding Poly(A) RNA Binding Protein N-terminus Binding Extracellular Matrix Binding
	Biological Process	Ventricular Cardiac Muscle Tissue Development Single Organismal Cell-cell Adhesion Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Fibril Organization Collagen Catabolic Process Homeostasis Of Number Of Cells Within A Tissue Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development	Kidney Development Placenta Development Carbohydrate Metabolic Process Skeletal Muscle Tissue Development Aging Pathogenesis Response To Mechanical Stimulus Organ Morphogenesis Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Extracellular Matrix Disassembly Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Chondroitin Sulfate Biosynthetic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Biosynthetic Process Response To Lipopolysaccharide Wound Healing Small Molecule Metabolic Process
Pathways		Collagen formation Collagen degradation Collagen biosynthesis and modifying enzymes Degradation of the extracellular matrix	MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Heparan sulfate/heparin (HS-GAG) metabolism Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism CS/DS degradation Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Degradation of the extracellular matrix Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora ECM proteoglycans Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A Dermatan sulfate biosynthesis MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS			Sudden cardiac arrest ( 21658281)
Protein-Protein Interactions		3 interactors: APP CD44 DCN	30 interactors: AHSG BRCA1 C1QA COL14A1 COL1A1 COL1A2 COL4A1 COL4A3 COL4A4 COL4A5 COL4A6 COL5A1 COL6A1 DPT EGFR ELN FBN1 FLNA FN1 MET MMP2 MMP3 MMP7 PLA2G2A SFTPD TGFB1 TGFB2 THBS1 TNF WISP1
Entrez ID		7373	1634
HPRD ID		00379	00501
Ensembl ID		ENSG00000187955	ENSG00000011465
Uniprot IDs		Q05707	P07585 Q6FH10
PDB IDs
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Glycosaminoglycan Catabolic Process Wound Healing Response To Wounding Extracellular Matrix Disassembly Glycosaminoglycan Metabolic Process Reproductive Process Pathogenesis Regulation Of Peptidyl-tyrosine Phosphorylation Synaptic Growth At Neuromuscular Junction Positive Regulation Of Monocyte Aggregation Monocyte Aggregation Collateral Sprouting In Absence Of Injury Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Kidney Development Renal System Development Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of Proteolysis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Protein Processing Urogenital System Development Regulation Of Endopeptidase Activity Wound Healing Involved In Inflammatory Response Axon Choice Point Recognition Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Blood Coagulation Hemostasis Small Molecule Metabolic Process Anatomical Structure Morphogenesis Neuron Remodeling Positive Regulation Of Heterotypic Cell-cell Adhesion Reproductive Structure Development Regulation Of Cellular Ketone Metabolic Process Reproductive System Development Peptide Cross-linking Via Chondroitin 4-sulfate Glycosaminoglycan Dermatan Sulfate Biosynthetic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Dermatan Sulfate Proteoglycan Biosynthetic Process Hyaluronan Catabolic Process Dermatan Sulfate Proteoglycan Metabolic Process Chondroitin Sulfate Catabolic Process Regulation Of Body Fluid Levels Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator	Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Cellular Response To Amino Acid Stimulus Locomotion Movement Of Cell Or Subcellular Component Response To Amino Acid Cell Morphogenesis Involved In Differentiation Response To External Stimulus Anatomical Structure Development Axon Guidance System Development Cellular Response To Acid Chemical Anatomical Structure Morphogenesis Multicellular Organismal Development Developmental Process Chemotaxis Cell Morphogenesis Collagen Fibril Organization Axonogenesis Cell Adhesion Catabolic Process Organ Development Axon Development Cell Morphogenesis Involved In Neuron Differentiation Cell Migration Cell Projection Morphogenesis Neuron Projection Morphogenesis Platelet Activation Cell Part Morphogenesis Cellular Response To Organonitrogen Compound Tissue Development Response To Stimulus Cell Motility Cell Development Response To Stress Regulation Of Cellular Component Organization Platelet Degranulation Neuron Projection Development Regulation Of Reactive Oxygen Species Metabolic Process Cardiovascular System Development Cell Projection Organization Cell Activation Face Morphogenesis Cellular Response To Organic Substance Positive Regulation Of Cell Migration
Tagcloud ?		cdkn2a clusters cpg dedifferentiated dmrt2 fbln2 humanmethylation27 hypermethylated hypermethylation hypomethylation infinium integrating inverse liposarcoma liposarcomas methylation myxoid neoplastic nnat partitioned pleomorphic pyroxd2 represented sarcomas showing soft speg usefulness znf217	architecture arise ascribed attached cerebellar cerebellum channels conductance deep excision golgi ideal identifiable mg2 native nmda nr2 nr2b nr2c nr2d openings patch patches powerful purkinje readily recordings represented suggestion
Tagcloud (Difference) ?		cdkn2a clusters cpg dedifferentiated dmrt2 fbln2 humanmethylation27 hypermethylated hypermethylation hypomethylation infinium integrating inverse liposarcoma liposarcomas methylation myxoid neoplastic nnat partitioned pleomorphic pyroxd2 sarcomas showing soft speg usefulness znf217	architecture arise ascribed attached cerebellar cerebellum channels conductance deep excision golgi ideal identifiable mg2 native nmda nr2 nr2b nr2c nr2d openings patch patches powerful purkinje readily recordings suggestion
Tagcloud (Intersection) ?		represented