PLPP3

Description		phospholipid phosphatase 3
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Plasma Membrane Adherens Junction Membrane Basolateral Plasma Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Membrane Raft Endoplasmic Reticulum Exit Site
	Molecular Function	Integrin Binding Protein Binding Phosphatidate Phosphatase Activity Hydrolase Activity Sphingosine-1-phosphate Phosphatase Activity Lipid Phosphatase Activity Delta-catenin Binding Ceramide-1-phosphate Phosphatase Activity
	Biological Process	Blood Vessel Development Gastrulation With Mouth Forming Second Lipid Metabolic Process Phospholipid Metabolic Process Sphingosine Metabolic Process Ceramide Metabolic Process Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Cell Adhesion Signal Transduction Integrin-mediated Signaling Pathway Positive Regulation Of Endothelial Cell Migration Regulation Of Wnt Signaling Pathway Sphingolipid Catabolic Process Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Transcription By RNA Polymerase II Phospholipid Dephosphorylation Protein Stabilization Bergmann Glial Cell Differentiation Cell-cell Adhesion Regulation Of Sphingolipid Mediated Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Endothelial Cell-matrix Adhesion Via Fibronectin
Pathways		Sphingolipid catabolism
Drugs
Diseases
GWAS		Coronary artery disease ( 33020668) Heel bone mineral density ( 30598549) Low density lipoprotein cholesterol levels ( 29403010) Myocardial infarction ( 33532862) Retinitis pigmentosa ( 33514863)
Interacting Genes		4 interacting genes: APP BCAR1 CTNND1 SHC1
Entrez ID		8613
HPRD ID		06179
Ensembl ID		ENSG00000162407
Uniprot IDs		O14495
PDB IDs
Enriched GO Terms of Interacting Partners?		Insulin Receptor Binding Ephrin Receptor Binding Cellular Response To Growth Factor Stimulus Cell Adhesion Regulation Of Superoxide Metabolic Process Response To Growth Factor Anchoring Junction Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Insulin Receptor Signaling Pathway Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cell Surface Receptor Signaling Pathway Negative Regulation Of Blood Vessel Branching Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Shc-EGFR Complex PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of ERK1 And ERK2 Cascade Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Protein Localization To Cell-cell Junction Positive Regulation Of Cell Proliferation In Bone Marrow Epidermal Growth Factor Binding Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Cell Proliferation In Bone Marrow Negative Regulation Of Multicellular Organismal Process Regulation Of Spontaneous Synaptic Transmission
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