PLPP3 and CTNND1

Number of citations: 44 (PubMedID 20123964)
Data Source: BioGRID (pull down)

		PLPP3	CTNND1
Name		phospholipid phosphatase 3	catenin delta 1
Structure		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Plasma Membrane Adherens Junction Membrane Basolateral Plasma Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Membrane Raft Endoplasmic Reticulum Exit Site	Nucleus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Membrane Catenin Complex Midbody Ciliary Basal Body Extracellular Exosome Anchoring Junction
	Molecular Function	Integrin Binding Protein Binding Phosphatidate Phosphatase Activity Hydrolase Activity Sphingosine-1-phosphate Phosphatase Activity Lipid Phosphatase Activity Delta-catenin Binding Ceramide-1-phosphate Phosphatase Activity	Signaling Receptor Binding Protein Binding Phosphatase Inhibitor Activity Phosphatase Binding Cadherin Binding Cell-cell Adhesion Mediator Activity Protein Sequestering Activity
	Biological Process	Blood Vessel Development Gastrulation With Mouth Forming Second Lipid Metabolic Process Phospholipid Metabolic Process Sphingosine Metabolic Process Ceramide Metabolic Process Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Cell Adhesion Signal Transduction Integrin-mediated Signaling Pathway Positive Regulation Of Endothelial Cell Migration Regulation Of Wnt Signaling Pathway Sphingolipid Catabolic Process Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Transcription By RNA Polymerase II Phospholipid Dephosphorylation Protein Stabilization Bergmann Glial Cell Differentiation Cell-cell Adhesion Regulation Of Sphingolipid Mediated Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Endothelial Cell-matrix Adhesion Via Fibronectin	Negative Regulation Of Transcription By RNA Polymerase II Cell Migration Involved In Sprouting Angiogenesis Cell Adhesion Negative Regulation Of D-glucose Transmembrane Transport Wnt Signaling Pathway Cell-cell Adhesion Mediated By Cadherin Protein Stabilization Cell-cell Adhesion Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Protein Localization To Cell-cell Junction Negative Regulation Of Intracellular Signal Transduction D-glucose Transmembrane Transport Negative Regulation Of Blood Vessel Branching
Pathways		Sphingolipid catabolism	Adherens junctions interactions VEGFR2 mediated vascular permeability InlA-mediated entry of Listeria monocytogenes into host cells Regulation of CDH11 function Regulation of CDH11 function Regulation of CDH19 Expression and Function Regulation of CDH1 Function Degradation of CDH1 CDH11 homotypic and heterotypic interactions
GWAS		Coronary artery disease ( 33020668 ) Heel bone mineral density ( 30598549 ) Low density lipoprotein cholesterol levels ( 29403010 ) Myocardial infarction ( 33532862 ) Retinitis pigmentosa ( 33514863 )	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Autism spectrum disorder or schizophrenia ( 28540026 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Household income (MTAG) ( 31844048 ) Neuroticism ( 29255261 ) Parkinson's disease ( 27182965 ) Pulse pressure ( 27841878 30578418 ) Reticulocyte fraction of red cells ( 32888494 ) Schizophrenia ( 25056061 29483656 ) Systolic blood pressure ( 27841878 )
Interacting Genes		4 interacting genes: APP BCAR1 CTNND1 SHC1	36 interacting genes: ACTA1 APP CDH1 CDH11 CDH24 CDH3 CDH5 COL17A1 CTTN EGFR EIF4A3 EIF4G3 ERBIN FER GRIK2 GSK3B JUP KCTD6 MAPK1 MAPK3 MTNR1B MUC1 PLPP3 PSEN1 PTPN6 PTPRJ PTPRM RNF26 RPS6KA3 SMURF1 SNCA SRC SUMO2 WEE2-AS1 YWHAG ZBTB33
Entrez ID		8613	1500
HPRD ID		06179	03026
Ensembl ID		ENSG00000162407	ENSG00000198561
Uniprot IDs		O14495	O60716
PDB IDs		Not available	3L6X 3L6Y
GO Terms Enriched among Interactors		Insulin Receptor Binding Ephrin Receptor Binding Cellular Response To Growth Factor Stimulus Cell Adhesion Regulation Of Superoxide Metabolic Process Response To Growth Factor Anchoring Junction Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Insulin Receptor Signaling Pathway Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cell Surface Receptor Signaling Pathway Negative Regulation Of Blood Vessel Branching Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Shc-EGFR Complex PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of ERK1 And ERK2 Cascade Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Protein Localization To Cell-cell Junction Positive Regulation Of Cell Proliferation In Bone Marrow Epidermal Growth Factor Binding Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Cell Proliferation In Bone Marrow Negative Regulation Of Multicellular Organismal Process Regulation Of Spontaneous Synaptic Transmission	Cadherin Binding Cell Adhesion Cell Junction Organization Regulation Of Multicellular Organismal Process Cell Junction Regulation Of Cell Communication Regulation Of Signaling Catenin Complex Beta-catenin Binding Regulation Of Signal Transduction Regulation Of Locomotion Cell Junction Assembly Negative Regulation Of Signaling Negative Regulation Of Cell Communication Adherens Junction Cell-cell Adhesion Cell-cell Adhesion Mediated By Cadherin Anchoring Junction Positive Regulation Of Biosynthetic Process Negative Regulation Of Signal Transduction Postsynapse Adherens Junction Organization Plasma Membrane Positive Regulation Of Macromolecule Metabolic Process Regulation Of Protein Metabolic Process Modulation Of Chemical Synaptic Transmission Regulation Of Cell Migration Cell-cell Junction Assembly Regulation Of Cell Motility Cell-cell Junction Positive Regulation Of Metabolic Process Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Surface Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Locomotion Regulation Of Gene Expression Negative Regulation Of Multicellular Organismal Process Regulation Of Macromolecule Biosynthetic Process Cell-cell Junction Organization Anatomical Structure Morphogenesis Regulation Of Macromolecule Metabolic Process ERBB2 Signaling Pathway Positive Regulation Of Cell Migration Developmental Process Glutamatergic Synapse Regulation Of Metabolic Process Regulation Of Synaptic Plasticity Epidermal Growth Factor Receptor Signaling Pathway