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PTPRH and GHR
Number of citations of the paper that reports this interaction (PubMedID
12907755
)
0
Data Source:
BioGRID
(pull down, far western blotting)
PTPRH
GHR
Description
protein tyrosine phosphatase receptor type H
growth hormone receptor
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Plasma Membrane
Microvillus
Membrane
Apical Plasma Membrane
Nuclear Speck
Microvillus Membrane
Cell Projection
Extracellular Region
Extracellular Space
Cytosol
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Membrane
Cytoplasmic Ribonucleoprotein Granule
Neuronal Cell Body
Receptor Complex
Growth Hormone Receptor Complex
Molecular Function
Phosphoprotein Phosphatase Activity
Protein Tyrosine Phosphatase Activity
Transmembrane Receptor Protein Tyrosine Phosphatase Activity
Protein Binding
Hydrolase Activity
Cadherin Binding
Cytokine Receptor Activity
Growth Hormone Receptor Activity
Protein Binding
Lipid Binding
Peptide Hormone Binding
Growth Factor Binding
Protein Kinase Binding
Protein Phosphatase Binding
Cytokine Binding
Protein Tyrosine Kinase Activator Activity
SH2 Domain Binding
Identical Protein Binding
Protein Homodimerization Activity
Proline-rich Region Binding
Protein Tyrosine Kinase Binding
Biological Process
Protein Dephosphorylation
Apoptotic Process
Signal Transduction
Axon Guidance
Endocytosis
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Cell Population Proliferation
Response To Gravity
Response To Hormone
Hormone-mediated Signaling Pathway
Cytokine-mediated Signaling Pathway
Taurine Metabolic Process
Receptor Internalization
Response To Food
Regulation Of Response To Nutrient Levels
Response To Estradiol
Cellular Response To Insulin Stimulus
Cellular Response To Hormone Stimulus
Response To Cytokine
Regulation Of Multicellular Organism Growth
Positive Regulation Of Multicellular Organism Growth
Hormone Metabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of MAPK Cascade
Response To Peptide Hormone
Positive Regulation Of Cell Differentiation
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Response To Cycloheximide
Insulin-like Growth Factor Receptor Signaling Pathway
Response To Glucocorticoid
Cartilage Development Involved In Endochondral Bone Morphogenesis
Growth Hormone Receptor Signaling Pathway
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Negative Regulation Of Growth Hormone Receptor Signaling Pathway
Response To Growth Hormone
Response To Interleukin-1
Pathways
Prolactin receptor signaling
Growth hormone receptor signaling
Growth hormone receptor signaling
Drugs
Somatotropin
Pegvisomant
Somatrem
Somapacitan
Lonapegsomatropin
Diseases
Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS
Mean spheric corpuscular volume (
32888494
)
Monocyte percentage of white cells (
32888494
)
Platelet count (
32888494
)
Platelet distribution width (
32888494
)
Plateletcrit (
27863252
32888494
)
Reticulocyte count (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Serum metabolite levels (
33031748
)
Systemic lupus erythematosus (
28714469
)
Appendicular lean mass (
33097823
)
Blood protein levels (
30072576
)
Familial squamous cell lung carcinoma (
29924316
)
Heel bone mineral density (
30598549
)
Height (
25429064
28552196
31562340
)
Hip circumference adjusted for BMI (
34021172
)
Iron status biomarkers (
19084217
)
Menarche (age at onset) (
25231870
)
Plasma renin activity levels (
29650764
)
Response to taxane treatment (docetaxel) (
23006423
)
Systemic lupus erythematosus (
18204098
)
Interacting Genes
16 interacting genes:
BCAR1
CNKSR1
CRK
DHPS
DOK1
EGFR
ERBB3
ERBB4
GHR
KRTAP10-3
KRTAP10-8
LCK
MAPK1
MLH1
PTK2
PXN
44 interacting genes:
AP2A1
BTRC
CISH
CUL1
CUL5
DUSP7
ELOB
ELOC
FBXO31
GH1
GH2
GRB10
GRB2
IRS1
JAK1
JAK2
NCOA6
NEDD8
PIK3R1
PIK3R2
PLCG1
PTPN1
PTPN11
PTPN13
PTPN2
PTPN3
PTPN6
PTPN9
PTPRB
PTPRH
RBX1
RNF7
SGTA
SHC1
SKP1
SOCS1
SOCS2
SOCS3
SRPK2
STAT3
STAT5A
STAT5B
STUB1
TYK2
Entrez ID
5794
2690
HPRD ID
03942
02971
Ensembl ID
ENSG00000080031
ENSG00000112964
Uniprot IDs
Q9HD43
A0A087X0H5
A0A087X162
P10912
PDB IDs
7XC0
1A22
1AXI
1HWG
1HWH
1KF9
2AEW
3HHR
5OEK
5OHD
6I5J
6I5N
Enriched GO Terms of Interacting Partners
?
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
ERBB2 Signaling Pathway
Cell Surface Receptor Signaling Pathway
Protein Phosphatase Binding
SH2 Domain Binding
Protein Tyrosine Kinase Activity
Protein Tyrosine Kinase Activator Activity
Signal Transduction
Regulation Of MAPK Cascade
Growth Hormone Receptor Signaling Pathway
Epidermal Growth Factor Receptor Activity
Neuregulin Receptor Activity
Positive Regulation Of MAPK Cascade
Protein Kinase Activity
Positive Regulation Of Macrophage Proliferation
Response To Growth Factor
Phosphotyrosine Residue Binding
Cell Migration
Positive Regulation Of Cell Population Proliferation
Peptidyl-tyrosine Phosphorylation
Regulation Of Immune Response
Kinase Activity
Response To Epidermal Growth Factor
B Cell Receptor Signaling Pathway
Signal Complex Assembly
ERBB2-ERBB3 Signaling Pathway
ERBB3 Signaling Pathway
Cell Motility
Receptor Complex
Basal Plasma Membrane
Immune Response-regulating Signaling Pathway
Focal Adhesion
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Immune System Process
Positive Regulation Of Protein Phosphorylation
Immune Response-activating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Growth
Positive Regulation Of Phosphorylation
Response To Hepatocyte Growth Factor
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Schwann Cell Development
Positive Regulation Of Cell Migration
T Cell Receptor Signaling Pathway
Growth Hormone Receptor Signaling Pathway
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Protein Modification Process
Cytokine-mediated Signaling Pathway
Intracellular Signal Transduction
Cell Surface Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Phosphotyrosine Residue Binding
Cell Surface Receptor Signaling Pathway Via STAT
Cytosol
Protein Dephosphorylation
Growth Hormone Receptor Binding
Protein Tyrosine Phosphatase Activity
Peptidyl-tyrosine Dephosphorylation
Signal Transduction
Protein Metabolic Process
Regulation Of Receptor Signaling Pathway Via JAK-STAT
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Insulin Receptor Signaling Pathway
Negative Regulation Of Signal Transduction
Macromolecule Metabolic Process
Cul5-RING Ubiquitin Ligase Complex
Dephosphorylation
Phosphoprotein Phosphatase Activity
Regulation Of Signal Transduction
Negative Regulation Of Growth Hormone Receptor Signaling Pathway
Erythropoietin-mediated Signaling Pathway
Regulation Of Insulin Receptor Signaling Pathway
Regulation Of Cellular Response To Insulin Stimulus
Protein Ubiquitination
Insulin Receptor Binding
Negative Regulation Of Insulin Receptor Signaling Pathway
Negative Regulation Of Cellular Response To Insulin Stimulus
Regulation Of Growth Hormone Receptor Signaling Pathway
Non-membrane Spanning Protein Tyrosine Phosphatase Activity
Protein Modification By Small Protein Conjugation
Regulation Of Signaling
Regulation Of Cell Communication
Post-translational Protein Modification
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Insulin-like Growth Factor Receptor Binding
Neurotrophin TRKA Receptor Binding
Regulation Of Cell Adhesion
Proteolysis Involved In Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Cytoplasm
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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