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CD36 and YES1
Number of citations of the paper that reports this interaction (PubMedID
1715582
)
58
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
CD36
YES1
Description
CD36 molecule (CD36 blood group)
YES proto-oncogene 1, Src family tyrosine kinase
Image
GO Annotations
Cellular Component
Extracellular Space
Golgi Apparatus
Plasma Membrane
Caveola
External Side Of Plasma Membrane
Cell Surface
Membrane
Apical Plasma Membrane
Endocytic Vesicle Membrane
Platelet Alpha Granule Membrane
Brush Border Membrane
Specific Granule Membrane
Receptor Complex
Membrane Raft
Apical Part Of Cell
Phagocytic Vesicle
Cell Periphery
Cytoplasm
Golgi Apparatus
Centrosome
Cytosol
Cytoskeleton
Actin Filament
Plasma Membrane
Focal Adhesion
Membrane
Extracellular Exosome
Anchoring Junction
Molecular Function
Amyloid-beta Binding
Low-density Lipoprotein Particle Receptor Activity
Scavenger Receptor Activity
Long-chain Fatty Acid Transmembrane Transporter Activity
Protein Binding
High-density Lipoprotein Particle Binding
Lipid Binding
Short-chain Fatty Acid Transmembrane Transporter Activity
Low-density Lipoprotein Particle Binding
Toll-like Receptor Binding
Cargo Receptor Activity
Protein-containing Complex Binding
Transforming Growth Factor Beta Binding
Thrombospondin Receptor Activity
Lipoteichoic Acid Immune Receptor Activity
Lipoprotein Particle Binding
Oxidised Low-density Lipoprotein Particle Receptor Activity
Oleate Transmembrane Transporter Activity
Nucleotide Binding
Phosphotyrosine Residue Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Signaling Receptor Binding
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Enzyme Binding
Transmembrane Transporter Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
MAPK Cascade
Positive Regulation Of Cell-matrix Adhesion
Production Of Molecular Mediator Involved In Inflammatory Response
Lipid Metabolic Process
Fatty Acid Metabolic Process
Lipid Transport
Receptor-mediated Endocytosis
Phagocytosis, Recognition
Phagocytosis, Engulfment
Cell Adhesion
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Blood Coagulation
Response To Bacterium
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Cholesterol Storage
Fatty Acid Transport
Long-chain Fatty Acid Transport
Long-chain Fatty Acid Import Across Plasma Membrane
Short-chain Fatty Acid Transport
Negative Regulation Of Angiogenesis
Lipid Storage
CGMP-mediated Signaling
Positive Regulation Of Blood Coagulation
Intestinal Cholesterol Absorption
Cholesterol Transport
Receptor Internalization
Regulation Of Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Tumor Necrosis Factor Production
Response To Lipid
Regulation Of Toll-like Receptor Signaling Pathway
Triglyceride Transport
Plasma Lipoprotein Particle Clearance
Low-density Lipoprotein Particle Clearance
Cellular Response To Oxidative Stress
Response To Stilbenoid
Nitric Oxide-cGMP-mediated Signaling
Negative Regulation Of Protein Import Into Nucleus
Lipoprotein Transport
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Regulation Of Protein-containing Complex Assembly
Apoptotic Cell Clearance
Positive Regulation Of MAPK Cascade
Long-chain Fatty Acid Import Into Cell
Positive Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Angiogenesis
Defense Response To Gram-positive Bacterium
Intestinal Absorption
Sensory Perception Of Taste
Low-density Lipoprotein Particle Mediated Signaling
Positive Regulation Of Phagocytosis, Engulfment
Positive Regulation Of Macrophage Cytokine Production
Positive Regulation Of ERK1 And ERK2 Cascade
Cholesterol Import
Response To Fatty Acid
Response To Linoleic Acid
Cellular Response To Bacterial Lipopeptide
Cellular Response To Lipopolysaccharide
Cellular Response To Lipoteichoic Acid
Cellular Response To Low-density Lipoprotein Particle Stimulus
Cellular Response To Hydroperoxide
Cellular Response To Diacyl Bacterial Lipopeptide
Energy Homeostasis
Regulation Of Action Potential
Positive Regulation Of Cold-induced Thermogenesis
Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus
Oxidised Low-density Lipoprotein Particle Clearance
Amyloid-beta Clearance By Cellular Catabolic Process
Positive Regulation Of NLRP3 Inflammasome Complex Assembly
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Reactive Oxygen Species Biosynthetic Process
Cellular Response To Amyloid-beta
Amyloid Fibril Formation
Lipid Transport Across Blood-brain Barrier
Regulation Of Removal Of Superoxide Radicals
Positive Regulation Of Blood Microparticle Formation
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of D-glucose Transmembrane Transport
Cell Differentiation
T Cell Costimulation
Cellular Response To Platelet-derived Growth Factor Stimulus
Protein Modification Process
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Regulation Of Vascular Permeability
Positive Regulation Of Transcription By RNA Polymerase II
Ephrin Receptor Signaling Pathway
Leukocyte Migration
Cellular Response To Retinoic Acid
Cellular Response To Transforming Growth Factor Beta Stimulus
Pathways
Platelet degranulation
Cross-presentation of particulate exogenous antigens (phagosomes)
ER-Phagosome pathway
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Toll Like Receptor TLR6:TLR2 Cascade
PPARA activates gene expression
Scavenging by Class B Receptors
Scavenging by Class B Receptors
Transcriptional regulation of white adipocyte differentiation
Intracellular metabolism of fatty acids regulates insulin secretion
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
Regulation of TLR by endogenous ligand
Interleukin-4 and Interleukin-13 signaling
Neutrophil degranulation
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Signaling by ERBB2
Signaling by SCF-KIT
Signaling by SCF-KIT
Regulation of KIT signaling
FCGR activation
PECAM1 interactions
EPH-Ephrin signaling
Co-stimulation by CD28
Co-inhibition by CTLA4
EPHB-mediated forward signaling
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells
RUNX2 regulates osteoblast differentiation
Regulation of signaling by CBL
Regulation of signaling by CBL
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated phagocytosis
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by CSF1 (M-CSF) in myeloid cells
Drugs
Dasatinib
Fostamatinib
Diseases
GWAS
Aspartate aminotransferase levels (
33339817
29403010
)
Basophil count (
32888494
)
Blood protein levels (
30072576
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Electrocardiographic traits (multivariate) (
32602732
)
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
HDL cholesterol (
23726366
30275531
)
HDL cholesterol levels in current drinkers (
30698716
)
HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) (
30698716
)
HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) (
30698716
)
Hemoglobin (
32888494
)
High density lipoprotein cholesterol levels (
29403010
33339817
)
Left ventricular mass (
19454037
)
Mean corpuscular hemoglobin concentration (
29403010
)
Mean corpuscular volume (
32888494
27863252
)
Mean platelet volume (
27863252
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Night sleep phenotypes (
27126917
)
Platelet count (
32888494
33545615
29403010
27863252
22423221
)
Plateletcrit (
32888494
)
Red blood cell count (
32888494
27863252
)
Red cell distribution width (
28957414
32888494
)
Response to fenofibrate (
22890011
)
Diastolic blood pressure (
29403010
30487518
)
Hypertension (
30487518
)
Mean arterial pressure (
29403010
30487518
)
PR interval in Tripanosoma cruzi seropositivity (
24324551
)
Pulmonary function in asthmatics (
23541324
)
Pursuit maintenance gain (
29064472
)
Systolic blood pressure (
29403010
30224653
30487518
30578418
)
Thyroid autoantibody positivity (anti-thyroglobulin (TgAb) and/or anti-thyroid peroxidase (TPOAb) levels) (
31794020
)
Interacting Genes
23 interacting genes:
APOB
APP
CD9
CHRD
COL1A1
COL1A2
FYN
HSD11B1
ITGA2B
ITGA6
ITGB1
ITGB3
LDLR
LY6H
LYN
MATK
NRN1
SCRG1
SRC
THBS1
VLDLR
VWC2L
YES1
98 interacting genes:
ADAM12
ADAM15
AMOTL2
AR
BCAR1
BECN1
BICD2
C1orf94
CARD9
CBL
CBLB
CBLC
CCDC33
CD2AP
CD36
CD46
CDH1
CDKN1B
CEP57L1
CEP83
CHMP1A
CPSF6
CRKL
CSF1R
DDIT4L
DENND2C
DES
DLG4
DOK1
DOK2
DRC4
DTX3
DVL2
EFS
EGFR
EPHB2
ERBB2
ERBB3
ERBB4
FASLG
FGFR1
FLACC1
FLT1
FUNDC1
FXR1
FXR2
GAB1
GFAP
GP6
IKZF3
ITGB4
JAK2
JAKMIP1
KDR
KHDRBS1
KIT
LASP1
LIN7C
MET
MST1R
NEDD4
NHERF1
NIF3L1
NPHS1
OGT
PAK2
PDCD6IP
PDGFRB
PECAM1
PICK1
PIK3R3
PTEN
PTK2
PTPRE
RASA1
RPL10
SH3GLB2
SKAP2
SOCS1
SOCS2
SOCS3
SOCS7
SPRR2A
SSBP3
STAP2
THAP1
TNK2
TP53BP2
TRAF2
TRAF6
TRIM5
TRPV4
TSGA10IP
TYRO3
ZBTB8A
ZC2HC1A
ZNF438
ZNF512B
Entrez ID
948
7525
HPRD ID
01430
01285
Ensembl ID
ENSG00000135218
ENSG00000176105
Uniprot IDs
A4D1B1
B7Z6C3
E9PLT1
P16671
P07947
PDB IDs
5LGD
2HDA
Enriched GO Terms of Interacting Partners
?
Developmental Process
Integrin Binding
Regulation Of Cell Migration
Regulation Of Cell Motility
Regulation Of Locomotion
Non-membrane Spanning Protein Tyrosine Kinase Activity
Anatomical Structure Morphogenesis
Protease Binding
Cellular Response To Platelet-derived Growth Factor Stimulus
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Positive Regulation Of Cell Migration
Fc Receptor Mediated Stimulatory Signaling Pathway
Response To Platelet-derived Growth Factor
Positive Regulation Of Cell Motility
Positive Regulation Of Locomotion
Integrin Complex
Ephrin Receptor Binding
Cellular Response To Growth Factor Stimulus
Fibrinogen Binding
Enzyme-linked Receptor Protein Signaling Pathway
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Signaling Receptor Activator Activity
Fc-gamma Receptor Signaling Pathway
Response To Growth Factor
Cellular Response To Lipoprotein Particle Stimulus
Integrin-mediated Signaling Pathway
External Side Of Plasma Membrane
Cell Surface Receptor Signaling Pathway
Regulation Of Developmental Process
System Development
T Cell Costimulation
Cell Motility
Regulation Of Leukocyte Migration
Regulation Of Cell Adhesion
Skin Morphogenesis
Ephrin Receptor Signaling Pathway
Protein Tyrosine Kinase Activity
Fc Receptor Signaling Pathway
Low-density Lipoprotein Particle
Cellular Response To Oxygen-containing Compound
Extracellular Space
Focal Adhesion
Cell Surface
Regulation Of Cell Activation
Cell Migration
Positive Regulation Of Fibroblast Migration
Regulation Of Mononuclear Cell Migration
Cellular Response To Transforming Growth Factor Beta Stimulus
Platelet Alpha Granule Membrane
Collagen Type I Trimer
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Cell Surface Receptor Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of MAPK Cascade
Positive Regulation Of MAPK Cascade
Receptor Complex
Positive Regulation Of Signal Transduction
Signal Transduction
Positive Regulation Of Cell Communication
Regulation Of Cell Communication
Positive Regulation Of Signaling
Regulation Of Signaling
Intracellular Signal Transduction
Peptidyl-tyrosine Phosphorylation
Regulation Of Signal Transduction
Regulation Of Programmed Cell Death
Regulation Of Protein Phosphorylation
Regulation Of Intracellular Signal Transduction
Identical Protein Binding
Regulation Of Phosphorylation
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Phosphorylation
Positive Regulation Of Protein Metabolic Process
Regulation Of Cell Migration
Regulation Of Apoptotic Process
Plasma Membrane
Regulation Of Protein Modification Process
Regulation Of Phosphorus Metabolic Process
Regulation Of Cell Motility
Regulation Of Developmental Process
Cell Migration
Negative Regulation Of Programmed Cell Death
Regulation Of Cellular Component Organization
Regulation Of Locomotion
Positive Regulation Of Phosphate Metabolic Process
Response To Growth Factor
Positive Regulation Of Protein Modification Process
Protein Kinase Activity
Cell Motility
SH3 Domain Binding
Regulation Of Protein Metabolic Process
Regulation Of Protein Kinase Activity
Protein Binding
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Cell Population Proliferation
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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