CD36 and FYN

Number of citations of the paper that reports this interaction (PubMedID 29269414)
51

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		CD36	FYN
Description		CD36 molecule (CD36 blood group)	FYN proto-oncogene, Src family tyrosine kinase
Image
GO Annotations	Cellular Component	Extracellular Space Golgi Apparatus Plasma Membrane Caveola External Side Of Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Endocytic Vesicle Membrane Platelet Alpha Granule Membrane Brush Border Membrane Specific Granule Membrane Receptor Complex Membrane Raft Apical Part Of Cell Phagocytic Vesicle Cell Periphery	Nucleus Cytoplasm Mitochondrion Endosome Cytosol Actin Filament Plasma Membrane Postsynaptic Density Membrane Dendrite Perikaryon Cell Body Membrane Raft Perinuclear Region Of Cytoplasm Cell Periphery Perinuclear Endoplasmic Reticulum Glial Cell Projection Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Postsynaptic Density, Intracellular Component
	Molecular Function	Amyloid-beta Binding Low-density Lipoprotein Particle Receptor Activity Scavenger Receptor Activity Long-chain Fatty Acid Transmembrane Transporter Activity Protein Binding High-density Lipoprotein Particle Binding Lipid Binding Short-chain Fatty Acid Transmembrane Transporter Activity Low-density Lipoprotein Particle Binding Toll-like Receptor Binding Cargo Receptor Activity Protein-containing Complex Binding Transforming Growth Factor Beta Binding Thrombospondin Receptor Activity Lipoteichoic Acid Immune Receptor Activity Lipoprotein Particle Binding Oxidised Low-density Lipoprotein Particle Receptor Activity Oleate Transmembrane Transporter Activity	Nucleotide Binding G Protein-coupled Receptor Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Tubulin Binding Phospholipase Activator Activity Kinase Activity Transferase Activity Enzyme Binding Type 5 Metabotropic Glutamate Receptor Binding T Cell Receptor Binding CD4 Receptor Binding CD8 Receptor Binding Identical Protein Binding Alpha-tubulin Binding Phospholipase Binding Phosphatidylinositol 3-kinase Binding Transmembrane Transporter Binding Protein-containing Complex Binding Metal Ion Binding Ephrin Receptor Binding Tau Protein Binding Tau-protein Kinase Activity Peptide Hormone Receptor Binding Growth Factor Receptor Binding Scaffold Protein Binding Disordered Domain Specific Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Positive Regulation Of Cell-matrix Adhesion Production Of Molecular Mediator Involved In Inflammatory Response Lipid Metabolic Process Fatty Acid Metabolic Process Lipid Transport Receptor-mediated Endocytosis Phagocytosis, Recognition Phagocytosis, Engulfment Cell Adhesion Cell Surface Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation Response To Bacterium Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Storage Fatty Acid Transport Long-chain Fatty Acid Transport Long-chain Fatty Acid Import Across Plasma Membrane Short-chain Fatty Acid Transport Negative Regulation Of Angiogenesis Lipid Storage CGMP-mediated Signaling Positive Regulation Of Blood Coagulation Intestinal Cholesterol Absorption Cholesterol Transport Receptor Internalization Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Response To Lipid Regulation Of Toll-like Receptor Signaling Pathway Triglyceride Transport Plasma Lipoprotein Particle Clearance Low-density Lipoprotein Particle Clearance Cellular Response To Oxidative Stress Response To Stilbenoid Nitric Oxide-cGMP-mediated Signaling Negative Regulation Of Protein Import Into Nucleus Lipoprotein Transport Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Protein-containing Complex Assembly Apoptotic Cell Clearance Positive Regulation Of MAPK Cascade Long-chain Fatty Acid Import Into Cell Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Defense Response To Gram-positive Bacterium Intestinal Absorption Sensory Perception Of Taste Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Phagocytosis, Engulfment Positive Regulation Of Macrophage Cytokine Production Positive Regulation Of ERK1 And ERK2 Cascade Cholesterol Import Response To Fatty Acid Response To Linoleic Acid Cellular Response To Bacterial Lipopeptide Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Cellular Response To Low-density Lipoprotein Particle Stimulus Cellular Response To Hydroperoxide Cellular Response To Diacyl Bacterial Lipopeptide Energy Homeostasis Regulation Of Action Potential Positive Regulation Of Cold-induced Thermogenesis Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Oxidised Low-density Lipoprotein Particle Clearance Amyloid-beta Clearance By Cellular Catabolic Process Positive Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Amyloid-beta Amyloid Fibril Formation Lipid Transport Across Blood-brain Barrier Regulation Of Removal Of Superoxide Radicals Positive Regulation Of Blood Microparticle Formation Positive Regulation Of Reactive Oxygen Species Metabolic Process	Response To Singlet Oxygen Neuron Migration Stimulatory C-type Lectin Receptor Signaling Pathway Adaptive Immune Response Immune System Process Negative Regulation Of Inflammatory Response To Antigenic Stimulus Heart Process Calcium Ion Transport Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Axon Guidance Learning Feeding Behavior Regulation Of Cell Shape Response To Xenobiotic Stimulus Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Neuron Projection Development Negative Regulation Of Angiogenesis Protein Ubiquitination Peptidyl-tyrosine Phosphorylation Layer Formation In Cerebral Cortex Natural Killer Cell Activation Cell Differentiation Protein Catabolic Process Forebrain Development Neuron Projection Development T Cell Costimulation Negative Regulation Of Protein Ubiquitination Intracellular Signal Transduction Cellular Response To Platelet-derived Growth Factor Stimulus Reelin-mediated Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Protein Catabolic Process Response To Cocaine Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Neuron Apoptotic Process Response To Ethanol Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Dendrite Morphogenesis Activated T Cell Proliferation Modulation Of Chemical Synaptic Transmission T Cell Receptor Signaling Pathway Leukocyte Migration Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Hydrogen Peroxide Cellular Response To Growth Factor Stimulus Cellular Response To Peptide Hormone Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Protein Targeting To Membrane Dendritic Spine Maintenance Positive Regulation Of Protein Localization To Nucleus Regulation Of Glutamate Receptor Signaling Pathway Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Dendritic Spine Maintenance Response To Amyloid-beta Cellular Response To Amyloid-beta Cellular Response To L-glutamate Cellular Response To Glycine Positive Regulation Of Protein Localization To Membrane Regulation Of Calcium Ion Import Across Plasma Membrane Regulation Of Neuron Migration Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Platelet degranulation Cross-presentation of particulate exogenous antigens (phagosomes) ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane Toll Like Receptor TLR6:TLR2 Cascade PPARA activates gene expression Scavenging by Class B Receptors Scavenging by Class B Receptors Transcriptional regulation of white adipocyte differentiation Intracellular metabolism of fatty acids regulates insulin secretion MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis	GPVI-mediated activation cascade Signaling by ERBB2 PIP3 activates AKT signaling Signaling by SCF-KIT Signaling by SCF-KIT Regulation of KIT signaling Nef and signal transduction Cell surface interactions at the vascular wall FCGR activation PECAM1 interactions Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling DAP12 signaling EPH-Ephrin signaling Role of LAT2/NTAL/LAB on calcium mobilization Nephrin family interactions Nephrin family interactions NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Co-stimulation by CD28 CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway Co-inhibition by CTLA4 EPHB-mediated forward signaling EPHB-mediated forward signaling EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling CRMPs in Sema3A signaling VEGFA-VEGFR2 Pathway Dectin-2 family CD209 (DC-SIGN) signaling RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Platelet Adhesion to exposed collagen Reelin signalling pathway Regulation of signaling by CBL Regulation of signaling by CBL FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by CSF1 (M-CSF) in myeloid cells FLT3 signaling through SRC family kinases Antigen activates B Cell Receptor (BCR) leading to generation of second messengers High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs			Dasatinib Triglyme Fostamatinib Zotiraciclib
Diseases
GWAS		Aspartate aminotransferase levels ( 33339817 29403010) Basophil count ( 32888494) Blood protein levels ( 30072576) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol ( 23726366 30275531) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hemoglobin ( 32888494) High density lipoprotein cholesterol levels ( 29403010 33339817) Left ventricular mass ( 19454037) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 32888494 27863252) Mean platelet volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Night sleep phenotypes ( 27126917) Platelet count ( 32888494 33545615 29403010 27863252 22423221) Plateletcrit ( 32888494) Red blood cell count ( 32888494 27863252) Red cell distribution width ( 28957414 32888494) Response to fenofibrate ( 22890011)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Anger ( 24489884) Autoimmune thyroid disease ( 32581359) Bipolar disorder ( 31043756) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 31562340) Inflammatory bowel disease ( 28067908 23128233) Intraocular pressure ( 29617998) Macular thickness ( 30535121) NASH resolution in nonalcoholic steatohepatitis ( 31832568) Parkinson's disease ( 32201043 32310270) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Schizophrenia ( 28991256 30285260) Systolic blood pressure ( 30578418) Ulcerative colitis ( 28067908)
Interacting Genes		23 interacting genes: APOB APP CD9 CHRD COL1A1 COL1A2 FYN HSD11B1 ITGA2B ITGA6 ITGB1 ITGB3 LDLR LY6H LYN MATK NRN1 SCRG1 SRC THBS1 VLDLR VWC2L YES1	199 interacting genes: ACP1 ADAM15 ADD2 ARHGAP32 ARHGAP33 ATXN1 BAG4 BCAR1 BCL3 BTK C7orf25 C8orf33 CASP3 CASP8 CAV1 CBL CBLB CBLC CD19 CD2 CD226 CD247 CD2AP CD36 CD44 CD48 CD5 CD55 CD79A CD79B CDH1 CDK1 CDK5 CLTC CMA1 CNN1 CNN3 CNTN1 CNTNAP1 CRK CSF1R CSF2RB CSK CTLA4 CTNNB1 CTNND2 DAG1 DLG4 DLGAP4 DOK1 DOK3 DOK4 DTX3 EFS ENO1 EPHA3 EPHA4 EPHA8 EPHB3 EVL FAM90A1 FAS FASLG FCER2 FCGR2A FLOT1 FLOT2 FLT1 FNBP4 FYB1 GAB3 GP6 GRAP GRB10 GRB2 GRIN1 GRIN2A GRIN2B GRSF1 HNRNPK HRAS HSP90AA1 HTR6 IGHA1 IL1B IL2RB IL7R IRS1 ITCH ITGB4 ITK ITPR1 JAK2 JUP KDM1A KDR KHDRBS1 KIT LAT LCK LCP2 MAG MAP2 MAPT MCAM MED28 MEOX2 MS4A1 NCAM1 NEDD4 NEDD9 NMT1 NOS1AP NPHS1 NR3C1 NTRK2 PAG1 PAK2 PDE4D PDGFRB PECAM1 PIK3R1 PIK3R2 PIK3R3 PLAUR PLCG1 PLCG2 PLD2 PRKCD PRKCE PRKCH PRKCQ PRKCZ PRMT6 PRMT8 PRRG4 PTK2 PTK2B PTPN11 PTPN5 PTPRA PTPRC PTPRE PTPRF PTPRZ1 PXN RACK1 RAF1 RPL10 RPS6KA3 RPS6KB2 SDC3 SH2B2 SH2D1A SH3BP2 SHC1 SIT1 SKAP1 SKAP2 SLAMF1 SNCA SOCS1 SOS1 SPHK1 SPHK2 SPN STAT1 STAT3 SUV39H1 SYK TAMALIN TCAP THY1 TNF TNK2 TNNT1 TOM1L1 TRAF6 TRAT1 TRIM55 TRIM63 TRPC6 TRPV4 TUBA1B TUBA3C TUBA4A TXK TYK2 TYRO3 UHRF2 UNC119 VAV1 VAV2 WAS WASF1 WASF2 WBP11 YTHDC1 ZAP70
Entrez ID		948	2534
HPRD ID		01430	00655
Ensembl ID		ENSG00000135218	ENSG00000010810
Uniprot IDs		A4D1B1 B7Z6C3 E9PLT1 P16671	P06241
PDB IDs		5LGD	1A0N 1AOT 1AOU 1AVZ 1AZG 1EFN 1FYN 1G83 1M27 1NYF 1NYG 1SHF 1ZBJ 2DQ7 2MQI 2MRJ 2MRK 3H0F 3H0H 3H0I 3UA6 3UA7 4D8D 4EIK 4U17 4U1P 4ZNX 5ZAU 6EDF 6IPY 6IPZ 7A2J 7A2K 7A2L 7A2M 7A2N 7A2O 7A2P 7A2Q 7A2R 7A2S 7A2T 7A2U 7A2V 7A2W 7A2X 7A2Y 7A2Z 7UD6 8KDX
Enriched GO Terms of Interacting Partners?		Developmental Process Integrin Binding Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Non-membrane Spanning Protein Tyrosine Kinase Activity Anatomical Structure Morphogenesis Protease Binding Cellular Response To Platelet-derived Growth Factor Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Cell Migration Fc Receptor Mediated Stimulatory Signaling Pathway Response To Platelet-derived Growth Factor Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Integrin Complex Ephrin Receptor Binding Cellular Response To Growth Factor Stimulus Fibrinogen Binding Enzyme-linked Receptor Protein Signaling Pathway Negative Regulation Of Inflammatory Response To Antigenic Stimulus Signaling Receptor Activator Activity Fc-gamma Receptor Signaling Pathway Response To Growth Factor Cellular Response To Lipoprotein Particle Stimulus Integrin-mediated Signaling Pathway External Side Of Plasma Membrane Cell Surface Receptor Signaling Pathway Regulation Of Developmental Process System Development T Cell Costimulation Cell Motility Regulation Of Leukocyte Migration Regulation Of Cell Adhesion Skin Morphogenesis Ephrin Receptor Signaling Pathway Protein Tyrosine Kinase Activity Fc Receptor Signaling Pathway Low-density Lipoprotein Particle Cellular Response To Oxygen-containing Compound Extracellular Space Focal Adhesion Cell Surface Regulation Of Cell Activation Cell Migration Positive Regulation Of Fibroblast Migration Regulation Of Mononuclear Cell Migration Cellular Response To Transforming Growth Factor Beta Stimulus Platelet Alpha Granule Membrane Collagen Type I Trimer	Cell Surface Receptor Signaling Pathway Signal Transduction Plasma Membrane Immune System Process Regulation Of Immune System Process Positive Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Immune Response Immune Response-activating Signaling Pathway Activation Of Immune Response Antigen Receptor-mediated Signaling Pathway Regulation Of Multicellular Organismal Process Regulation Of Signal Transduction Regulation Of Cell Adhesion Leukocyte Activation Enzyme-linked Receptor Protein Signaling Pathway Cell Activation Positive Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Cell Communication Regulation Of Cellular Component Organization Phosphotyrosine Residue Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Multicellular Organismal Process Lymphocyte Activation Positive Regulation Of Cell Adhesion Membrane Raft Regulation Of Cell Activation T Cell Receptor Signaling Pathway Cell Migration Positive Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Protein Tyrosine Kinase Activity Immune Response Regulation Of Cell-cell Adhesion Regulation Of Programmed Cell Death Intracellular Signaling Cassette Fc Receptor Signaling Pathway Regulation Of Apoptotic Process SH2 Domain Binding Adaptive Immune Response Cell Adhesion Protein Kinase Binding
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