CD36 and MATK

Number of citations of the paper that reports this interaction (PMID 9171348)
11

Data Source:
HPRD (in vivo)

		CD36	MATK
Gene Name		CD36 molecule (thrombospondin receptor)	megakaryocyte-associated tyrosine kinase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Endocytic Vesicle Membrane Platelet Alpha Granule Membrane Membrane Raft Phagocytic Vesicle	Cytosol Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
	Molecular Function	Low-density Lipoprotein Receptor Activity High-density Lipoprotein Particle Binding Lipid Binding Low-density Lipoprotein Particle Binding Transforming Growth Factor Beta Binding Thrombospondin Receptor Activity Lipoteichoic Acid Receptor Activity Lipoprotein Particle Binding	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell-matrix Adhesion Toll-like Receptor Signaling Pathway Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Platelet Degranulation MyD88-dependent Toll-like Receptor Signaling Pathway Lipid Metabolic Process Receptor-mediated Endocytosis Phagocytosis, Recognition Cell Adhesion Cell Surface Receptor Signaling Pathway Nitric Oxide Mediated Signal Transduction Blood Coagulation Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Storage Plasma Membrane Long-chain Fatty Acid Transport Lipid Storage CGMP-mediated Signaling Platelet Activation Positive Regulation Of Blood Coagulation Cholesterol Transport Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Plasma Lipoprotein Particle Clearance Low-density Lipoprotein Particle Clearance Response To Stilbenoid Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Lipoprotein Transport Negative Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Cell Clearance Positive Regulation Of MAPK Cascade Negative Regulation Of Growth Of Symbiont In Host Cellular Lipid Metabolic Process Small Molecule Metabolic Process Long-chain Fatty Acid Import Innate Immune Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Gram-positive Bacterium Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Phagocytosis, Engulfment Positive Regulation Of Macrophage Cytokine Production Cellular Response To Bacterial Lipopeptide Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Cellular Response To Hydroperoxide Regulation Of Removal Of Superoxide Radicals Positive Regulation Of Blood Microparticle Formation Positive Regulation Of Reactive Oxygen Species Metabolic Process	Morphogenesis Of An Epithelium Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Mesoderm Development Cell Proliferation Positive Regulation Of Cell Proliferation Cell Migration Cell Differentiation Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Innate Immune Response
Pathways		PPARA activates gene expression Metabolism of lipids and lipoproteins Platelet degranulation Toll Like Receptor TLR6:TLR2 Cascade Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade Response to elevated platelet cytosolic Ca2+ Transcriptional regulation of white adipocyte differentiation MyD88:Mal cascade initiated on plasma membrane Class I MHC mediated antigen processing & presentation Innate Immune System Fatty acid, triacylglycerol, and ketone body metabolism Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Platelet activation, signaling and aggregation Scavenging by Class B Receptors Antigen processing-Cross presentation Cross-presentation of particulate exogenous antigens (phagosomes) Adaptive Immune System	Signaling by ERBB2
Drugs
Diseases
GWAS		HDL cholesterol ( 23726366) Left ventricular mass ( 19454037) Mean platelet volume ( 22423221) Response to fenofibrate ( 22890011)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		18 interactors: APP CD9 CHRD COL1A1 COL1A2 FYN HSD11B1 ITGA2B ITGA6 ITGB1 ITGB3 LDLR LYN MATK SRC THBS1 VLDLR YES1	10 interactors: CACNA1A CD36 ERBB2 EWSR1 KIT LYN NTRK1 PTK2B PXN SRC
Entrez ID		948	4145
HPRD ID		01430	02496
Ensembl ID		ENSG00000135218	ENSG00000007264
Uniprot IDs		A4D1B1 P16671	F1T0G6 K7EQY5 P42679
PDB IDs			1JWO 1X6G 3US4
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Platelet Activation Response To Wounding Leukocyte Migration Movement Of Cell Or Subcellular Component Locomotion Cell Activation Anatomical Structure Morphogenesis Vesicle-mediated Transport Cell Migration Cell Motility Endocytosis Platelet Degranulation Anatomical Structure Development Peptidyl-tyrosine Autophosphorylation System Development Positive Regulation Of Cell Adhesion Extracellular Matrix Organization Extracellular Structure Organization Axon Guidance Regulation Of Cell Adhesion Developmental Process Response To External Stimulus Multicellular Organismal Development Axonogenesis Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Cell Differentiation Positive Regulation Of Cellular Component Movement Response To Stress Immune System Process Axon Development Positive Regulation Of Locomotion Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Cell Migration Chemotaxis Regulation Of Cell Motility Neuron Projection Morphogenesis Organ Development Regulation Of Locomotion Cell Surface Receptor Signaling Pathway Regulation Of Cellular Component Movement Cell Morphogenesis Involved In Differentiation Integrin-mediated Signaling Pathway Regulation Of Cell Proliferation Response To Abiotic Stimulus Cell Projection Organization	Peptidyl-tyrosine Phosphorylation Regulation Of MAPK Cascade Positive Regulation Of Protein Phosphorylation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of MAPK Cascade Protein Autophosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Transferase Activity Regulation Of MAP Kinase Activity Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Cell Projection Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Phosphatidylinositol 3-kinase Activity Regulation Of Protein Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation ERBB Signaling Pathway Regulation Of Kinase Activity Regulation Of Lipid Kinase Activity Regulation Of ERK1 And ERK2 Cascade Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Kinase Activity Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of MAP Kinase Activity Regulation Of Cell Projection Organization Peptidyl-amino Acid Modification Signal Complex Assembly Regulation Of Intracellular Signal Transduction Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Cell Development Response To External Stimulus Cellular Response To Organic Substance Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Cell Activation Cell Surface Receptor Signaling Pathway Leukocyte Differentiation Cell Morphogenesis Involved In Differentiation Protein Phosphorylation Regulation Of Protein Metabolic Process Positive Regulation Of Cell Adhesion Response To Stress
Tagcloud ?		benzidine bfu cd41 cd71 cfu csf cytokines e2 epo erythroid erythropoiesis erythropoietin events express gata glycophorin gm interestingly late leukemia line lineage pas progenitor reagent stages strictly transforming understand	atpb barcodes barcoding biodiversity characters chloroplast classifying cox1 discipline endangered epitome fashionable forensic fundamentally gapdh helping identifications molecularization naming ndhf orthologous rbcl revolutionary stretches suddenly taxonomist taxonomy transitioning trnl
Tagcloud (Difference) ?		benzidine bfu cd41 cd71 cfu csf cytokines e2 epo erythroid erythropoiesis erythropoietin events express gata glycophorin gm interestingly late leukemia line lineage pas progenitor reagent stages strictly transforming understand	atpb barcodes barcoding biodiversity characters chloroplast classifying cox1 discipline endangered epitome fashionable forensic fundamentally gapdh helping identifications molecularization naming ndhf orthologous rbcl revolutionary stretches suddenly taxonomist taxonomy transitioning trnl
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