CD36 and ITGA2B

Number of citations of the paper that reports this interaction (PMID 11238109)
24

Data Source:
HPRD (in vivo)

		CD36	ITGA2B
Gene Name		CD36 molecule (thrombospondin receptor)	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Endocytic Vesicle Membrane Platelet Alpha Granule Membrane Membrane Raft Phagocytic Vesicle	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Platelet Alpha Granule Membrane Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Low-density Lipoprotein Receptor Activity High-density Lipoprotein Particle Binding Lipid Binding Low-density Lipoprotein Particle Binding Transforming Growth Factor Beta Binding Thrombospondin Receptor Activity Lipoteichoic Acid Receptor Activity Lipoprotein Particle Binding	Protein Binding Identical Protein Binding Metal Ion Binding Extracellular Matrix Binding Fibrinogen Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cell-matrix Adhesion Toll-like Receptor Signaling Pathway Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Platelet Degranulation MyD88-dependent Toll-like Receptor Signaling Pathway Lipid Metabolic Process Receptor-mediated Endocytosis Phagocytosis, Recognition Cell Adhesion Cell Surface Receptor Signaling Pathway Nitric Oxide Mediated Signal Transduction Blood Coagulation Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Storage Plasma Membrane Long-chain Fatty Acid Transport Lipid Storage CGMP-mediated Signaling Platelet Activation Positive Regulation Of Blood Coagulation Cholesterol Transport Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Plasma Lipoprotein Particle Clearance Low-density Lipoprotein Particle Clearance Response To Stilbenoid Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Lipoprotein Transport Negative Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Cell Clearance Positive Regulation Of MAPK Cascade Negative Regulation Of Growth Of Symbiont In Host Cellular Lipid Metabolic Process Small Molecule Metabolic Process Long-chain Fatty Acid Import Innate Immune Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Gram-positive Bacterium Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Phagocytosis, Engulfment Positive Regulation Of Macrophage Cytokine Production Cellular Response To Bacterial Lipopeptide Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Cellular Response To Hydroperoxide Regulation Of Removal Of Superoxide Radicals Positive Regulation Of Blood Microparticle Formation Positive Regulation Of Reactive Oxygen Species Metabolic Process	Platelet Degranulation Positive Regulation Of Leukocyte Migration Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Axon Guidance Blood Coagulation Platelet Activation Extracellular Matrix Organization Platelet Aggregation
Pathways		PPARA activates gene expression Metabolism of lipids and lipoproteins Platelet degranulation Toll Like Receptor TLR6:TLR2 Cascade Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade Response to elevated platelet cytosolic Ca2+ Transcriptional regulation of white adipocyte differentiation MyD88:Mal cascade initiated on plasma membrane Class I MHC mediated antigen processing & presentation Innate Immune System Fatty acid, triacylglycerol, and ketone body metabolism Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Platelet activation, signaling and aggregation Scavenging by Class B Receptors Antigen processing-Cross presentation Cross-presentation of particulate exogenous antigens (phagosomes) Adaptive Immune System	Signal transduction by L1 Axon guidance p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling L1CAM interactions Platelet degranulation GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet Aggregation (Plug Formation) Response to elevated platelet cytosolic Ca2+ ECM proteoglycans Integrin cell surface interactions Platelet activation, signaling and aggregation
Drugs			Abciximab Tirofiban
Diseases
GWAS		HDL cholesterol ( 23726366) Left ventricular mass ( 19454037) Mean platelet volume ( 22423221) Response to fenofibrate ( 22890011)	Platelet counts ( 22139419)
Protein-Protein Interactions		18 interactors: APP CD9 CHRD COL1A1 COL1A2 FYN HSD11B1 ITGA2B ITGA6 ITGB1 ITGB3 LDLR LYN MATK SRC THBS1 VLDLR YES1	15 interactors: AUP1 CALR CAMK2A CD36 CIB1 CLNS1A COL1A2 COL2A1 F2 FGA GRB2 ITGB3 PRKACA TLN1 VWF
Entrez ID		948	3674
HPRD ID		01430	06377
Ensembl ID		ENSG00000135218	ENSG00000005961
Uniprot IDs		A4D1B1 P16671	P08514
PDB IDs			1DPK 1DPQ 1JX5 1KUP 1KUZ 1M8O 1RN0 1S4W 1TYE 1UV9 2K1A 2K9J 2KNC 2VC2 2VDK 2VDL 2VDM 2VDN 2VDO 2VDP 2VDQ 2VDR 3FCS 3FCU 3NID 3NIF 3NIG 3T3M 3T3P 3ZDX 3ZDY 3ZDZ 3ZE0 3ZE1 3ZE2
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Platelet Activation Response To Wounding Leukocyte Migration Movement Of Cell Or Subcellular Component Locomotion Cell Activation Anatomical Structure Morphogenesis Vesicle-mediated Transport Cell Migration Cell Motility Endocytosis Platelet Degranulation Anatomical Structure Development Peptidyl-tyrosine Autophosphorylation System Development Positive Regulation Of Cell Adhesion Extracellular Matrix Organization Extracellular Structure Organization Axon Guidance Regulation Of Cell Adhesion Developmental Process Response To External Stimulus Multicellular Organismal Development Axonogenesis Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Cell Differentiation Positive Regulation Of Cellular Component Movement Response To Stress Immune System Process Axon Development Positive Regulation Of Locomotion Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Cell Migration Chemotaxis Regulation Of Cell Motility Neuron Projection Morphogenesis Organ Development Regulation Of Locomotion Cell Surface Receptor Signaling Pathway Regulation Of Cellular Component Movement Cell Morphogenesis Involved In Differentiation Integrin-mediated Signaling Pathway Regulation Of Cell Proliferation Response To Abiotic Stimulus Cell Projection Organization	Platelet Activation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Platelet Degranulation Response To Stress Positive Regulation Of Phosphorylation Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Immune System Process Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Cell Adhesion Positive Regulation Of Protein Phosphorylation Positive Regulation Of Transport Leukocyte Migration Cellular Response To Organic Substance Cellular Component Assembly Regulation Of Blood Coagulation Positive Regulation Of Protein Modification Process Vesicle-mediated Transport Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Cell-substrate Adhesion Regulation Of Wound Healing Regulation Of Cell Adhesion Regulation Of Signaling Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Protein Phosphorylation Exocytosis Positive Regulation Of Cellular Protein Metabolic Process Platelet Aggregation Cell Adhesion Response To Organic Substance Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Locomotion Positive Regulation Of Signal Transduction Regulation Of Cell-substrate Adhesion Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Protein Kinase Activity Cardiovascular System Development Positive Regulation Of Kinase Activity Negative Regulation Of Protein Metabolic Process Transport Secretion By Cell Movement Of Cell Or Subcellular Component
Tagcloud ?		benzidine bfu cd41 cd71 cfu csf cytokines e2 epo erythroid erythropoiesis erythropoietin events express gata glycophorin gm interestingly late leukemia line lineage pas progenitor reagent stages strictly transforming understand	actively agilent altogether calmodulin cardiotonic circulation cldn16 downregulating eclampsia enkur esr1 fermt1 fltv3 grin2c hbmec interrogated marinobufagenin mbg microarrays microvascular monolayers permeability physiology preeclampsia sflt slc8a1 tmem207 transcriptomes vegfr
Tagcloud (Difference) ?		benzidine bfu cd41 cd71 cfu csf cytokines e2 epo erythroid erythropoiesis erythropoietin events express gata glycophorin gm interestingly late leukemia line lineage pas progenitor reagent stages strictly transforming understand	actively agilent altogether calmodulin cardiotonic circulation cldn16 downregulating eclampsia enkur esr1 fermt1 fltv3 grin2c hbmec interrogated marinobufagenin mbg microarrays microvascular monolayers permeability physiology preeclampsia sflt slc8a1 tmem207 transcriptomes vegfr
Tagcloud (Intersection) ?