CBFA2T3 and CHRM4

Number of citations: 90 (PubMedID 28298427)
Data Source: BioGRID (two hybrid)

		CBFA2T3	CHRM4
Name		CBFA2/RUNX1 partner transcriptional co-repressor 3	cholinergic receptor muscarinic 4
Structure
GO Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Nucleolus Golgi Apparatus Membrane	Plasma Membrane Membrane Dendrite Synapse Postsynaptic Membrane
	Molecular Function	Transcription Corepressor Activity Protein Binding Zinc Ion Binding Metal Ion Binding	G Protein-coupled Receptor Activity G Protein-coupled Acetylcholine Receptor Activity
	Biological Process	Response To Hypoxia DNA-templated Transcription Negative Regulation Of Cell Population Proliferation Cell Differentiation Granulocyte Differentiation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Glycolytic Process Negative Regulation Of DNA-templated Transcription Regulation Of Aerobic Respiration	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Chemical Synaptic Transmission Regulation Of Locomotion
Pathways		None	Muscarinic acetylcholine receptors G alpha (i) signalling events
Drugs		None	Ziprasidone Amitriptyline Olanzapine Metixene Terfenadine Clozapine Doxylamine Trihexyphenidyl Procyclidine Loxapine Carbamoylcholine Hyoscyamine Meperidine Imipramine Darifenacin Nortriptyline Amoxapine Cinnarizine Atropine Nicardipine Paroxetine Homatropine methylbromide Trimipramine Scopolamine Benzquinamide Propiomazine Tropicamide Brompheniramine Maprotiline Methantheline Glycopyrronium Bethanechol Tolterodine Promethazine Pilocarpine Doxepin Desipramine Ketamine Quetiapine Aripiprazole Chlorprothixene Methotrimeprazine Tiotropium Solifenacin Isopropamide Acetylcholine ALKS 27 Fesoterodine Methacholine Hexocyclium Aclidinium Umeclidinium Trimebutine Dosulepin Viloxazine Etoperidone Homatropine Thonzylamine Revefenacin Propiverine Rociverine Aripiprazole lauroxil
GWAS		Annualised percent change of cerebrospinal fluid AB1-42 levels ( 31370031 ) Carotid intima media thickness ( 30510157 ) Carotid intima media thickness (mean) ( 31801372 ) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189 ) Hair color ( 26926045 ) Hemoglobin levels ( 32327693 ) Immature fraction of reticulocytes ( 32888494 ) Levodopa-induced dyskinesia in levodopa treated Parkinson's disease ( 32733355 ) Lymphocyte percentage of white cells ( 32888494 ) Mean corpuscular hemoglobin ( 27863252 32888494 ) Mean corpuscular volume ( 32888494 ) Mean platelet volume ( 27863252 32888494 ) Mean reticulocyte volume ( 32888494 ) Multiple sclerosis ( 31604244 ) Neutrophil count ( 32888494 ) Red cell distribution width ( 32888494 ) Red vs. brown/black hair color ( 30531825 ) Social autistic-like traits ( 24133439 ) Vitiligo ( 27723757 )	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Schizophrenia ( 28991256 29483656 )
Novel Interactors		1 novel interactors: NUP98	None recorded
Interacting Genes		23 interacting genes: ARHGEF6 CBFA2T2 CHRM4 DRC4 EPM2AIP1 GATAD2A GMEB2 HDAC1 HDAC3 MATN2 PIN1 PRKAR2A RTN4IP1 RUNX1 RUNX1T1 SEC24A TCF3 VPS37C ZBTB33 ZBTB38 ZBTB4 ZBTB47 ZNF652	22 interacting genes: B2M CBFA2T3 CD59 CD81 CFTR EEF1A2 ERGIC3 GPRASP1 GRB2 MCL1 METTL9 QSOX1 RAB3A RHBDD2 RTN4 SLC60A1 SMIM7 SNCA SYN2 TM7SF2 TSPAN7 YIPF3
Entrez ID		863	1132
HPRD ID		04847	00330
Ensembl ID		ENSG00000129993	ENSG00000180720
Uniprot IDs		O75081	P08173
PDB IDs		9DE2	5DSG 6D9H 6KP6 7LD3 7LD4 7TRK 7TRP 7TRQ 7TRS 7V68 7V69 7V6A 8E9X 8FX5 8IYH 8IYW 8JER 8JHN
GO Terms Enriched among Interactors		Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Binding Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Protein Lysine Delactylase Activity Methyl-CpG Binding Negative Regulation Of RNA Metabolic Process Protein Decrotonylase Activity Histone Decrotonylase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Transcription Corepressor Binding DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Histone Deacetylase Activity, Hydrolytic Mechanism Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Zinc Ion Binding Protein Deacetylation Protein Lysine Deacetylase Activity Transcription Corepressor Activity Nucleoplasm NuRD Complex RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Myotube Differentiation Negative Regulation Of Macromolecule Metabolic Process Histone Deacetylase Activity Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Cell Fate Specification Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Macromolecule Deacylation NF-kappaB Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Telomere Tethering At Nuclear Periphery Cis-trans Isomerase Activity Positive Regulation Of Ferroptosis Methyl-CpNpG Binding Regulation Of Metabolic Process Negative Regulation Of Striated Muscle Cell Differentiation Histone Deacetylase Complex Regulation Of Myotube Differentiation Regulation Of Cell Fate Commitment	Membrane Neurotransmitter Secretion Regulation Of Chaperone-mediated Autophagy Golgi Membrane Receptor Internalization Synaptic Vesicle Clustering Positive Regulation Of Exocytosis Positive Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Protein Localization Vesicle-mediated Transport In Synapse Endoplasmic Reticulum Membrane Neurotransmitter Transport Transport Vesicle Negative Regulation Of Autophagy Regulated Exocytosis Positive Regulation Of T Cell Cytokine Production Response To Iron Ion Positive Regulation Of Transport Regulation Of T Cell Cytokine Production MHC Class II Protein Complex Binding Leukocyte Mediated Immunity Amyloid Fibril Formation Regulation Of Cytokine Production Involved In Immune Response Lymphocyte Mediated Immunity Golgi Apparatus Regulation Of Aerobic Respiration Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Macrophage Fusion Vesicle-mediated Transport Positive Regulation Of Adaptive Immune Memory Response CD4-positive, Alpha-beta T Cell Costimulation Cholesterol Biosynthetic Process Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Regulation Of Autophagy Positive Regulation Of Lipid Kinase Activity Guanyl-nucleotide Exchange Factor Adaptor Activity Synaptic Vesicle Calcium-ion Regulated Exocytosis Regulation Of Presynaptic Dense Core Granule Exocytosis Regulation Of Vesicle Fusion Synaptic Vesicle Transport Terminal Bouton Signal Release Vesicle Localization Synaptic Vesicle Exocytosis Evoked Neurotransmitter Secretion Synaptic Vesicle Membrane